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Hiraku Onishi
Hoshi University
Organic chemistryChemistryIn vivoChromatographyBiochemistry
129Publications
24H-index
2,014Citations
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Publications 146
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Recently, the potential of nanoparticles (NPs) in ulcerative colitis (UC) therapy has been increasingly demonstrated. Namely, anionic NPs have been found to be accumulated efficiently to the UC damaged area due to epithelial enhanced permeability and retention (eEPR) effect. Previously, a novel anionic nanogel system (NG(S)) was prepared, and evaluated for the efficacy and toxicity. In the present study, release behaviors and biodistribution were investigated in detail to elucidate the functiona...
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#1Yuri Ikeuchi-Takahashi (Hoshi University)H-Index: 3
#2Yudai Shiokawa (Hoshi University)
Last. Hiraku Onishi (Hoshi University)H-Index: 24
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AbstractNovel microparticles coated with poly-γ-glutamic acid (PGA) were developed to improve the oral absorption of indomethacin (IM), a poorly water-soluble drug. Microparticles containing γ-IM (...
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#1Kaoru Hirose (TMU: Tokyo Medical University)H-Index: 1
#2Masanaho Sasatsu (Hoshi University)H-Index: 10
Last. Hiraku Onishi (Hoshi University)H-Index: 24
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1 CitationsSource
#1Yoshiyuki Hattori (Hoshi University)H-Index: 29
#2Nozomi Takeuchi (Hoshi University)H-Index: 2
Last. Hiraku Onishi (Hoshi University)H-Index: 24
view all 8 authors...
Abstract Previously, we reported that intravenous injection of chondroitin sulfate (CS), followed by intravenous injection of cationic liposome/siRNA complex (cationic lipoplex) could deliver siRNA into the liver. In this study, we examined the effects of the type of cationic lipid in the liposome on siRNA delivery into the liver. We used 6 types of cationic cholesterol derivatives and 11 types of dialkyl or trialkyl cationic lipids, and prepared 17 types of cationic liposomes to evaluate the ge...
2 CitationsSource
#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Osamu Sakata (Hoshi University)H-Index: 6
Abstract Etilefrine hydrochloride (ET-HCl) is used in the treatment of hypotension. Dosage forms of orally administered tablets and parenteral injections are clinically available, but exhibit unfavorable characteristics, including cardiac toxicity, headaches, and damage at the injection site for the parenteral dosage form, and initially high plasma levels, fast elimination, and first-pass effects for its oral administration. Therefore, the buccal application of ET-HCl was herein investigated as ...
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#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Masashi Nakamura (Hoshi University)H-Index: 1
Last. Masanaho Sasatsu (Hoshi University)H-Index: 10
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1 CitationsSource
#1Yuri Ikeuchi-Takahashi (Hoshi University)H-Index: 3
Last. Hiraku Onishi (Hoshi University)H-Index: 24
view all 6 authors...
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#1Yoshiyuki Hattori (Hoshi University)H-Index: 29
#2Yoko Machida (Hoshi University)H-Index: 2
Last. Hiraku Onishi (Hoshi University)H-Index: 24
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AbstractPurpose: Previously, we reported that the cationic liposomes composed of a cationic cholesterol derivative, cholesteryl (2-((2-hydroxyethyl)amino)ethyl)carbamate (OH-C-Chol) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) (termed LP-C), could deliver small interfering RNAs (siRNAs) with high transfection efficiency into tumor cells. In this study, to develop a liposomal vector for siRNA delivery in vivo, we prepared the poly(ethyleneglycol) (PEG)-modified cationic liposomes (LP-...
9 CitationsSource
#1Yoshiyuki Hattori (Hoshi University)H-Index: 29
#2Ayako Nakamura (Hoshi University)H-Index: 4
Last. Hiraku Onishi (Hoshi University)H-Index: 24
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Abstract Previously, we found that intravenous injection of chondroitin sulfate (CS), followed by intravenous injection of siRNA/cationic liposome complexes (siRNA lipoplexes) could deliver siRNAs to the liver and suppress expression of target genes. Here, we examined the effect of injection order of CS and siRNA lipoplexes on the biodistribution of siRNA and gene silencing in the liver after sequential injection. When siRNA lipoplexes were injected intravenously into mice, the siRNA largely acc...
2 CitationsSource
#1Hiraku Onishi (Hoshi University)H-Index: 24
#2Ai Fukasawa (Hoshi University)H-Index: 1
Last. Yoshiyuki Hattori (Hoshi University)H-Index: 29
view all 6 authors...
AbstractMacromolecule–antitumour drug conjugates can reach tumour sites specifically via the enhanced permeability and retention (EPR) effect. It is desirable to release the drug efficiently from the conjugate at acidic pH in the tumour tissue or in the endosomes of cancer cells. In this study, we attempted to produce a carrier system with a labile chemical bond at acidic pH. Adipic acid dihydrazide (ADH)-chondroitin sulfate (CS) (termed CS-ACH) was synthesised by a two-step method, with the int...
2 CitationsSource
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