Diverse feather shape evolution enabled by coupling anisotropic signalling modules with self-organizing branching programme

Published on Apr 1, 2017in Nature Communications11.878
· DOI :10.1038/ncomms14139
Ang Li8
Estimated H-index: 8
(SC: University of Southern California),
Seth Figueroa2
Estimated H-index: 2
(UCI: University of California, Irvine)
+ 4 AuthorsCheng-Ming Chuong64
Estimated H-index: 64
Asymmetric feather vane shape was a critical innovation in feather evolution and adaptation for flight. Here, Li and colleagues characterize the multi-module regulatory network that controls feather vane shape and underlies feather diversification.
Figures & Tables
  • References (42)
  • Citations (14)
📖 Papers frequently viewed together
4 Authors (Mingke Yu, ..., Cheng-Ming Chuong)
161 Citations
43 Citations
95 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Ang Li (SC: University of Southern California)H-Index: 8
#2Yung-Chih Lai (SC: University of Southern California)H-Index: 5
Last. Cheng-Ming Chuong (SC: University of Southern California)H-Index: 64
view all 8 authors...
Background: How tissue patterns form in development and regeneration is a fundamental issue remaining to be fully understood. The integument often forms repetitive units in space (periodic patterning) and time (cyclic renewal), such as feathers and hairs. Integument patterns are visible and experimentally manipulatable, helping us reveal pattern formative processes. Variability is seen in regional phenotypic specificities and temporal cycling at different physiological stages. Results: Here we s...
8 CitationsSource
#1Teresa J. Feo (Yale University)H-Index: 8
#2Daniel J. Field (Yale University)H-Index: 15
Last. Richard O. Prum (Yale University)H-Index: 47
view all 3 authors...
The geometry of feather barbs (barb length and barb angle) determines feather vane asymmetry and vane rigidity, which are both critical to a feather's aerodynamic performance. Here, we describe the relationship between barb geometry and aerodynamic function across the evolutionary history of asymmetrical flight feathers, from Mesozoic taxa outside of modern avian diversity (Microraptor, Archaeopteryx, Sapeornis, Confuciusornis and the enantiornithine Eopengornis) to an extensive sample of modern...
36 CitationsSource
#1Chih Feng Chen (NCHU: National Chung Hsing University)H-Index: 3
#2John FoleyH-Index: 19
Last. Cheng-Ming Chuong (SC: University of Southern California)H-Index: 64
view all 8 authors...
43 CitationsSource
#1Xing Xu (CAS: Chinese Academy of Sciences)H-Index: 44
#2ZHOUZhonghe (CAS: Chinese Academy of Sciences)H-Index: 47
Last. David J. Varricchio (MSU: Montana State University)H-Index: 28
view all 7 authors...
108 CitationsSource
#1Teresa J. Feo (Yale University)H-Index: 8
#2Richard O. Prum (Yale University)H-Index: 47
Asymmetry in flight feather vane width is a major functional innovation associated with the evolutionof flightintheancestorsofbirds.However,thedevelopmentalandmorphologicalbasisof feathershapeisnotsimple, andthedevelopmental processesinvolved invanewidthasymmetry are poorly understood. We present a theoretical model of feather morphology and development that describes the possible ways to modify feather development and produce vane asymmetry. Our model finds that the theoretical morphospace of f...
7 CitationsSource
#1Gareth J. Dyke (University of Southampton)H-Index: 28
#2Roeland de Kat (University of Southampton)H-Index: 13
Last. Bharathram Ganapathisubramani (University of Southampton)H-Index: 24
view all 6 authors...
Some early flying dinosaurs, such as the Early Creataceous Microraptor, possessed four wings, but their aerodynamic performance is poorly understood. Dyke et al. show that Microraptor did not require sophisticated wing morphology to undertake effective glides, supporting the view that the origin of feathers in dinosaurs is not associated with flight.
25 CitationsSource
#1Rushikesh ShethH-Index: 8
#2Damien GrégoireH-Index: 3
Last. Marie Kmita (UdeM: Université de Montréal)H-Index: 23
view all 9 authors...
Limb development relies on an exquisite coordination between growth and patterning, but the underlying mechanisms remain elusive. Anterior-posterior and proximal-distal specification initiates in early limb bud concomitantly with the proliferative expansion of limb cells. Previous studies have shown that limb bud growth initially relies on fibroblast growth factors (FGFs) produced in the apical ectodermal ridge (AER-FGFs), the maintenance of which relies on a positive-feedback loop involving son...
33 CitationsSource
#1Henner F. Farin (Hochschule Hannover)H-Index: 21
#2Timo H.-W. Lüdtke (Hochschule Hannover)H-Index: 8
Last. Andreas Kispert (Hochschule Hannover)H-Index: 65
view all 8 authors...
Vertebrate limb outgrowth is driven by a positive feedback loop that involves Sonic hedgehog (Shh) and Gremlin1 (Grem1) in the posterior limb bud mesenchyme and Fibroblast growth factors (Fgfs) in the overlying epithelium. Proper spatio-temporal control of these signaling activities is required to avoid limb malformations such as polydactyly. Here we show that, in Tbx2-deficient hindlimbs, Shh/Fgf4 signaling is prolonged, resulting in increased limb bud size and duplication of digit 4. In turn, ...
22 CitationsSource
#1Zhicao Yue (SC: University of Southern California)H-Index: 10
#2Ting Xin Jiang (SC: University of Southern California)H-Index: 18
Last. Cheng-Ming Chuong (SC: University of Southern California)H-Index: 64
view all 5 authors...
In a feather, there are distinct morphologies along the proximal–distal axis. The proximal part is a cylindrical stalk (calamus), whereas the distal part has barb and barbule branches. Here we focus on what molecular signaling activity can modulate feather stem cells to generate these distinct morphologies. We demonstrate the drastic tissue remodeling during feather cycling which includes initiation, growth and resting phases. In the growth phase, epithelial components undergo progressive change...
24 CitationsSource
#1Chen Siang Ng (AS: Academia Sinica)H-Index: 9
#2Ping Wu (SC: University of Southern California)H-Index: 23
Last. Cheng-Ming Chuong (SC: University of Southern California)H-Index: 64
view all 16 authors...
Feathers have complex forms and are an excellent model to study the development and evolution of morphologies. Existing chicken feather mutants are especially useful for identifying genetic determinants of feather formation. This study focused on the gene F, underlying the frizzle feather trait that has a characteristic curled feather rachis and barbs in domestic chickens. Our developmental biology studies identified defects in feather medulla formation, and physical studies revealed that the fr...
50 CitationsSource
Cited By14
#1Wen-yan XieH-Index: 1
Last. Chun-qi GaoH-Index: 9
view all 6 authors...
Abstract Avian feathers have robust growth and regeneration capability and serve as a useful model for decoding hair morphogenesis and other developmental studies. However, the molecular signaling involved in regulating the development of feather follicles is unclear. The purpose of this study was to investigate the role of the Wnt/β-catenin pathway in regulating feather morphogenesis in embryonic chicks through in ovo injection of different doses of Dickkopf-1 (DKK1, a specific inhibitor of the...
Last. Cheng-Ming ChuongH-Index: 64
view all 3 authors...
#1M. X. Chen (SCAU: South China Agricultural University)H-Index: 2
view all 6 authors...
The normal growth and regeneration of feathers is important for improving the welfare and economic value of poultry. Feather follicle stem cells are the basis for driving feather development and are regulated by various molecular signaling pathways in the feather follicle microenvironment. To date, the roles of the Wnt, Bone Morphogenetic Protein (BMP), Notch, and Sonic Hedgehog (SHH) signaling pathways in the regulation of feather growth and regeneration are among the best understood. While the...
#1Qing NieH-Index: 30
#2Lingxia QiaoH-Index: 1
Last. Weisheng ZhaoH-Index: 67
view all 5 authors...
Stochasticity (or noise) at cellular and molecular levels has been observed extensively as a universal feature for living systems. However, how living systems deal with noise while performing desirable biological functions remains a major mystery. Regulatory network congurations, such as their topology and timescale, are shown to be critical in attenuating noise, and noise is also found to facilitate cell fate decision. Here we review major recent ndings on noise attenuation through regulatory c...
#1Wei Ling Chang (PRC: China Medical University (PRC))H-Index: 1
#2Hao Wu (AS: Academia Sinica)H-Index: 1
Last. Cheng-Ming Chuong (SC: University of Southern California)H-Index: 64
view all 31 authors...
Summary The evolution of flight in feathered dinosaurs and early birds over millions of years required flight feathers whose architecture features hierarchical branches. While barb-based feather forms were investigated, feather shafts and vanes are understudied. Here, we take a multi-disciplinary approach to study their molecular control and bio-architectural organizations. In rachidial ridges, epidermal progenitors generate cortex and medullary keratinocytes, guided by Bmp and transforming grow...
2 CitationsSource
#1Xinlei WangH-Index: 1
Last. Xiangtao KangH-Index: 11
view all 18 authors...
Background Coloration is one of the most recognizable characteristics in chickens, and clarifying the coloration mechanisms will help us understand feather color formation. “Yufen I” is a commercial egg-laying chicken breed in China that was developed by a three-line cross using lines H, N and D. Columbian plumage is a typical feather character of the “Yufen I” H line. To elucidate the molecular mechanism underlying the pigmentation of Columbian plumage, this study utilizes high-throughput seque...
#1Michael J. Benton (UoB: University of Bristol)H-Index: 68
#2Danielle DhouaillyH-Index: 25
Last. Maria E. McNamara (UCC: University College Cork)H-Index: 14
view all 4 authors...
Feathers have long been regarded as the innovation that drove the success of birds. However, feathers have been reported from close dinosaurian relatives of birds, and now from ornithischian dinosaurs and pterosaurs, the cousins of dinosaurs. Incomplete preservation makes these reports controversial. If true, these findings shift the origin of feathers back 80 million years before the origin of birds. Gene regulatory networks show the deep homology of scales, feathers, and hairs. Hair and feathe...
2 CitationsSource
#1Dong-Won Kim (Johns Hopkins University)H-Index: 4
#2Luis A. Garza (Johns Hopkins University)H-Index: 9
1 CitationsSource