Last. Michael B. Habib(SC: University of Southern California)H-Index: 11
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The rachises of extant feathers, composed of dense cortex and spongy internal medulla, are flexible and light, yet stiff enough to withstand the load required for flight, among other functions. Incomplete knowledge of early feathers prevents a full understanding of how cylindrical rachises have evolved. Bizarre feathers with unusually wide and flattened rachises, known as "rachis-dominated feathers" (RDFs) have been observed in fossil non-avian and avian theropods. Newly discovered RDFs embedded...
#1Ya-Chen Liang(SC: University of Southern California)H-Index: 3
#2Ping Wu(SC: University of Southern California)H-Index: 39
Last. David Huang(SC: University of Southern California)H-Index: 64
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Summary Regional specification is critical for skin development, regeneration, and evolution. The contribution of epigenetics in this process remains unknown. Here, using avian epidermis, we find two major strategies regulate β-keratin gene clusters. (1) Over the body, macro-regional specificities (scales, feathers, claws, etc.) established by typical enhancers control five subclusters located within the epidermal differentiation complex on chromosome 25; (2) within a feather, micro-regional spe...
Injectable Biphasic calcium phosphate bone cements (BCPCs) composed of beta-tricalcium phosphate (beta-TCP) and hydroxyapatite (HA) have been intensively investigated because their high biodegradation rate, bioactivity and osteoconductivity which can be adjusted by changing the ratio between beta-TCP and HA phases after setting. The aim of this study was to evaluate the performance of 1 wt% chitosan fiber additive with biphasic calcium phosphate for injectable bone cement both in vitro and in vi...
Last. Cheng-Ming Chuong(SC: University of Southern California)H-Index: 64
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Feathers are considered to be one of the most complex integumentary organs. The diverse morphology of a feather has made it a popular platform for investigating the cellular and molecular mechanisms for regional specificity, periodical patterning, organ shaping, and regeneration over the past two decades. Paleontological findings on feathered dinosaurs and Mesozoic birds have led to the identification of some unusual and unexpected intermediate or extinct feather forms, which can all be categori...
Last. Shih-Chieh Hung(PRC: China Medical University (PRC))H-Index: 41
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In most cancers, cellular origin and the contribution of intrinsic and extrinsic factors toward transformation remain elusive. Cell specific carcinogenesis models are currently unavailable. To investigate cellular origin in carcinogenesis, we developed a tumorigenesis model based on a combination of carcinogenesis and genetically engineered mouse models. We show in organoids that treatment of any of three carcinogens, DMBA, MNU, or PhIP, with protein phosphatase 2A (PP2A) knockout induced tumori...