P2-318: Assessing Geographic Variability in Cognitive and Functional Baseline Scores in a Large Multinational Trial of Mild-to-Moderate Alzheimer's Disease

AD endpoints are translated and culturally adapted for multiregional trials with the intent of preserving their cognitive and functional concepts. However, data supporting performance of AD endpoints across countries and cultures are sparse. To examine the potential influence of culture on the measurement of cognition and function, we evaluated regional variability in the ADAS-Cog and the ADCS-ADL using baseline data from a global trial of...