Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents
Abstract
No targeted therapies have been found to be effective against hepatocellular carcinoma (HCC), possibly due to the large degree of intratumor heterogeneity. We performed genetic analyses of different regions of HCCs to evaluate levels of intratumor heterogeneity and associate alterations with responses to different pharmacologic agents.We obtained samples of HCCs (associated with hepatitis B virus infection) from 10 patients undergoing curative...
Paper Details
Title
Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents
Published Date
Jan 1, 2017
Journal
Volume
152
Issue
1
Pages
232 - 242.e4
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History