Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling
Abstract
Atherosclerosis is primarily a disease of lipid metabolism and inflammation; however, it is also closely associated with endothelial extracellular matrix (ECM) remodelling, with fibronectin accumulating in the laminin–collagen basement membrane. To investigate how fibronectin modulates inflammation in arteries, we replaced the cytoplasmic tail of the fibronectin receptor integrin α5 with that of the collagen/laminin receptor integrin α2. This...
Paper Details
Title
Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling
Published Date
Sep 5, 2016
Journal
Volume
18
Issue
10
Pages
1043 - 1053
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History