Martin A. Schwartz
Yale University
Publications 341
#1Xiao Hu (Yale University)H-Index: 2
#2Zongzhi Liu (Yale University)H-Index: 11
Last.Shangqin Guo (Yale University)H-Index: 12
view all 20 authors...
Actin cytoskeleton is well-known for providing structural/mechanical support, but whether and how it regulates chromatin and cell fate reprogramming is far less clear. Here, we report that MKL1, the key transcriptional co-activator of many actin cytoskeletal genes, regulates genomic accessibility and cell fate reprogramming. The MKL1-actin pathway weakens during somatic cell reprogramming by pluripotency transcription factors. Cells that reprogram efficiently display low endogenous MKL1 and inhi...
1 CitationsSource
#1Martin A. Schwartz (Yale University)H-Index: 92
#1Sanguk YunH-Index: 6
#2Rui HuH-Index: 1
Last.Martin A. SchwartzH-Index: 92
view all 8 authors...
#1Martin A. Schwartz (Yale University)H-Index: 92
#1Pei-Yu Chen (Yale University)H-Index: 14
#2Lingfeng Qin (Yale University)H-Index: 21
Last.Michael Simons (Yale University)H-Index: 95
view all 27 authors...
Atherosclerosis is a progressive vascular disease triggered by interplay between abnormal shear stress and endothelial lipid retention. A combination of these and, potentially, other factors leads to a chronic inflammatory response in the vessel wall, which is thought to be responsible for disease progression characterized by a buildup of atherosclerotic plaques. Yet molecular events responsible for maintenance of plaque inflammation and plaque growth have not been fully defined. Here we show th...
2 CitationsSource
#1Angel G. Solis (Yale University)H-Index: 3
#2Piotr Bielecki (Yale University)H-Index: 15
Last.Richard A. Flavell (Yale University)H-Index: 208
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Direct recognition of invading pathogens by innate immune cells is a critical driver of the inflammatory response. However, cells of the innate immune system can also sense their local microenvironment and respond to physiological fluctuations in temperature, pH, oxygen and nutrient availability, which are altered during inflammation. Although cells of the immune system experience force and pressure throughout their life cycle, little is known about how these mechanical processes regulate the im...
9 CitationsSource
#1Jeremy Herrera (University of Manchester)H-Index: 1
#2Venkatesh Mallikarjun (University of Manchester)H-Index: 3
Last.Joe Swift (University of Manchester)H-Index: 21
view all 9 authors...
Haematoxylin and eosin (H&E), which respectively stain nuclei blue and other cellular and stromal material pink, are routinely used for clinical diagnosis based on the identification of morphological features. A richer characterization can be achieved by laser capture microdissection coupled to mass spectrometry (LCM-MS), giving an unbiased assay of the proteins that make up the tissue. However, the process of fixing, and H&E staining of tissues is poorly compatible with standard sample preparat...
#1Abhishek Kumar (Yale University)H-Index: 11
#2Maria S. Shutova (UPenn: University of Pennsylvania)H-Index: 4
Last.Martin A. Schwartz (Yale University)H-Index: 92
view all 7 authors...
Cell sensing of externally applied mechanical strain through integrin-mediated adhesions is critical in development and physiology of muscle, lung, tendon, and arteries, among others. We examined the effects of strain on force transmission through the essential cytoskeletal linker talin. Using a fluorescence-based talin tension sensor (TS), we found that uniaxial stretch of cells on elastic substrates increased tension on talin, which was unexpectedly independent of the orientation of the focal ...
#1Martin A. Schwartz (Yale University)H-Index: 92