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Martin A. Schwartz
Yale University
319Publications
91H-index
36.6kCitations
Publications 319
Newest
Published on Apr 12, 2019in Nature Communications 11.88
Xiao Hu (Yale University), Zongzhi Liu10
Estimated H-index: 10
(Yale University)
+ 17 AuthorsAnna E Eastman (Yale University)
Actin cytoskeleton is well-known for providing structural/mechanical support, but whether and how it regulates chromatin and cell fate reprogramming is far less clear. Here, we report that MKL1, the key transcriptional co-activator of many actin cytoskeletal genes, regulates genomic accessibility and cell fate reprogramming. The MKL1-actin pathway weakens during somatic cell reprogramming by pluripotency transcription factors. Cells that reprogram efficiently display low endogenous MKL1 and inhi...
Published in Nature 43.07
Angel G. Solis2
Estimated H-index: 2
(Yale University),
Piotr Bielecki14
Estimated H-index: 14
(Yale University)
+ -3 AuthorsAutumn G. York1
Estimated H-index: 1
(Yale University)
Direct recognition of invading pathogens by innate immune cells is a critical driver of the inflammatory response. However, cells of the innate immune system can also sense their local microenvironment and respond to physiological fluctuations in temperature, pH, oxygen and nutrient availability, which are altered during inflammation. Although cells of the immune system experience force and pressure throughout their life cycle, little is known about how these mechanical processes regulate the im...
Published in Journal of Clinical Investigation 12.28
Sanguk Yun5
Estimated H-index: 5
,
Rui Hu1
Estimated H-index: 1
+ -3 AuthorsMartin A. Schwartz91
Estimated H-index: 91
Published on Jul 17, 2019in Journal of Cell Biology 8.89
Abhishek Kumar15
Estimated H-index: 15
(Yale University),
Maria S. Shutova4
Estimated H-index: 4
(UPenn: University of Pennsylvania)
+ 4 AuthorsMartin A. Schwartz91
Estimated H-index: 91
(Yale University)
Published on Jun 3, 2019in Circulation 23.05
Cristina M. Ramírez21
Estimated H-index: 21
(Yale University),
Xinbo Zhang9
Estimated H-index: 9
(Yale University)
+ 18 AuthorsVictoria Ulrich2
Estimated H-index: 2
(Yale University)
Background: Atherosclerosis is driven by synergistic interactions between pathological, biomechanical, inflammatory, and lipid metabolic factors. Our previous studies demonstrated that absence of c...
Published on Jul 5, 2019in bioRxiv
Elizabeth Min2
Estimated H-index: 2
(Yale University),
Nicolas Baeyens11
Estimated H-index: 11
(ULB: Université libre de Bruxelles)
+ 9 AuthorsMichael Simons91
Estimated H-index: 91
(Yale University)
Rationale: Blood vessel remodeling in response to changes in tissue demand is an important aspect of fitness and is often compromised in vascular disease. Endothelial cell (EC) sensing of fluid shear stress (FSS) governs vessel remodeling to maintain FSS at a specific magnitude or set point in healthy vessels. Objective: The purpose of this study was to understand how shear stress-regulated Smad 2/3 contributes to artery remodeling. Methods and Results: We found that shear stress induces Smad 2/...
Published on Jun 24, 2019in bioRxiv
Sanguk Yun5
Estimated H-index: 5
(Yale University),
Rui Hu1
Estimated H-index: 1
(Yale University)
+ 5 AuthorsMartin A. Schwartz91
Estimated H-index: 91
(Yale University)
Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin binding to integrin a5, which recruits and activates phosphodiesterase 4D5 (PDE4D5) by inducing its dephosphorylation on an inhibitory site Ser651. Active PDE then hydrolyzes anti-inflammatory cAMP to facilitate inflammatory signaling. To test this model in vivo, we mutated the integrin binding site in PDE4D5 in mic...
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