Match!
Sanguk Yun
Yale University
IntegrinInflammationVE-cadherinBiologyCell biology
11Publications
6H-index
437Citations
What is this?
Publications 12
Newest
#1Angel G. Solis (Yale University)H-Index: 3
#2Piotr Bielecki (Yale University)H-Index: 15
Last. Richard A. Flavell (Yale University)H-Index: 208
view all 16 authors...
Source
#1Sanguk YunH-Index: 6
#2Rui HuH-Index: 1
Last. Martin A. SchwartzH-Index: 92
view all 8 authors...
Source
#1Angel G. Solis (Yale University)H-Index: 3
#2Piotr Bielecki (Yale University)H-Index: 15
Last. Richard A. Flavell (Yale University)H-Index: 208
view all 16 authors...
Direct recognition of invading pathogens by innate immune cells is a critical driver of the inflammatory response. However, cells of the innate immune system can also sense their local microenvironment and respond to physiological fluctuations in temperature, pH, oxygen and nutrient availability, which are altered during inflammation. Although cells of the immune system experience force and pressure throughout their life cycle, little is known about how these mechanical processes regulate the im...
12 CitationsSource
#1Sanguk Yun (Yale University)H-Index: 6
#2Rui Hu (Yale University)H-Index: 1
Last. Martin A. Schwartz (Yale University)H-Index: 92
view all 8 authors...
Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin binding to integrin a5, which recruits and activates phosphodiesterase 4D5 (PDE4D5) by inducing its dephosphorylation on an inhibitory site Ser651. Active PDE then hydrolyzes anti-inflammatory cAMP to facilitate inflammatory signaling. To test this model in vivo, we mutated the integrin binding site in PDE4D5 in mic...
Source
#1Madhusudhan Budatha (Yale University)H-Index: 12
#2Jiasheng Zhang (Yale University)H-Index: 21
Last. Martin A. Schwartz (Yale University)H-Index: 92
view all 7 authors...
BackgroundFibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin ...
6 CitationsSource
#1Min Soo Kim (Gachon University)H-Index: 6
#2Sangmin Lee (UPR-RP: UPRRP College of Natural Sciences)
Last. Wook Jin (Gachon University)H-Index: 7
view all 9 authors...
Abstract The DJ-1 protein engages in diverse cellular and pathological processes, including tumorigenesis, apoptosis, sperm fertilization, and the progression of Parkinson’s disease (PD). The functional dimeric form of DJ-1 transforms into non-functional filamentous aggregates in an inorganic phosphate (P i )-dependent manner in vitro. Here, we demonstrated that P i and reactive oxygen species (ROS) induce DJ-1 aggregation in Neuro2A and SH-SY5Y cells. Remarkably, tartrate treatment significantl...
Source
#1Sanguk YunH-Index: 6
#2Madhusudhan BudathaH-Index: 12
Last. Martin A. SchwartzH-Index: 92
view all 9 authors...
Using a chimaeric integrin α5 (where the tail is replaced by that of α2), Yun et al. show that in endothelial cells, integrin α5 interacts with the cAMP-specific phosphodiesterase PDE4D5 to reduce cAMP levels and inflammation both in vitro and in vivo.
28 CitationsSource
#1Sanguk YunH-Index: 6
#2Madhusudhan BudathaH-Index: 12
Last. Dana Z. AndersonH-Index: 103
view all 9 authors...
Abstract Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into biochemical signals that regulate gene expression and cell behavior via specialized mechanisms and pathways. These pathways shape the vascular system during development and during postnatal and adult life to optimize flow to tissues. The same pathways also contribute to atherosclerosis and vascular malformations. This Review covers recent advances in basic mechanisms of flow signaling and the invo...
108 CitationsSource
#1Brian G. Coon (Yale University)H-Index: 12
#2Nicolas Baeyens (Yale University)H-Index: 11
Last. Martin A. SchwartzH-Index: 92
view all 9 authors...
Endothelial responses to fluid shear stress are essential for vascular development and physiology, and determine the formation of atherosclerotic plaques at regions of disturbed flow. Previous work identified VE-cadherin as an essential component, along with PECAM-1 and VEGFR2, of a complex that mediates flow signaling. However, VE-cadherin’s precise role is poorly understood. We now show that the transmembrane domain of VE-cadherin mediates an essential adapter function by binding directly to t...
27 CitationsSource
12