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Sanguk Yun
Yale University
11Publications
5H-index
397Citations
Publications 11
Newest
Published on Sep 1, 2019in Nature43.07
Angel G. Solis3
Estimated H-index: 3
(Yale University),
Piotr Bielecki14
Estimated H-index: 14
(Yale University)
+ 13 AuthorsAutumn G. York2
Estimated H-index: 2
(Yale University)
Direct recognition of invading pathogens by innate immune cells is a critical driver of the inflammatory response. However, cells of the innate immune system can also sense their local microenvironment and respond to physiological fluctuations in temperature, pH, oxygen and nutrient availability, which are altered during inflammation. Although cells of the immune system experience force and pressure throughout their life cycle, little is known about how these mechanical processes regulate the im...
Published on 2019in Journal of Clinical Investigation12.28
Sanguk Yun5
Estimated H-index: 5
,
Rui Hu1
Estimated H-index: 1
+ 5 AuthorsMartin A. Schwartz91
Estimated H-index: 91
Published on Jun 24, 2019in bioRxiv
Sanguk Yun5
Estimated H-index: 5
(Yale University),
Rui Hu1
Estimated H-index: 1
(Yale University)
+ 5 AuthorsMartin A. Schwartz91
Estimated H-index: 91
(Yale University)
Fibronectin in the vascular wall promotes inflammatory activation of the endothelium during vascular remodeling and atherosclerosis. These effects are mediated in part by fibronectin binding to integrin a5, which recruits and activates phosphodiesterase 4D5 (PDE4D5) by inducing its dephosphorylation on an inhibitory site Ser651. Active PDE then hydrolyzes anti-inflammatory cAMP to facilitate inflammatory signaling. To test this model in vivo, we mutated the integrin binding site in PDE4D5 in mic...
Published on Feb 1, 2018in Journal of the American Heart Association4.66
Madhusudhan Budatha11
Estimated H-index: 11
(Yale University),
Jiasheng Zhang21
Estimated H-index: 21
(Yale University)
+ 4 AuthorsMartin A. Schwartz91
Estimated H-index: 91
BackgroundFibronectin in endothelial basement membranes promotes endothelial inflammatory activation and atherosclerosis but also promotes plaque stability and vascular remodeling. The fibronectin receptor α5 subunit is proinflammatory through binding to and activating phosphodiesterase 4D5, which inhibits anti‐inflammatory cyclic adenosine monophosphate and protein kinase A. Replacing the α5 cytoplasmic domain with that of α2 resulted in smaller atherosclerotic plaques. Here, we further assesse...
Published on Feb 1, 2018in International Journal of Biological Macromolecules4.78
Min Soo Kim4
Estimated H-index: 4
(Gachon University),
Sangmin Lee (UPR-RP: UPRRP College of Natural Sciences)+ 6 AuthorsWook Jin20
Estimated H-index: 20
(Gachon University)
Abstract The DJ-1 protein engages in diverse cellular and pathological processes, including tumorigenesis, apoptosis, sperm fertilization, and the progression of Parkinson’s disease (PD). The functional dimeric form of DJ-1 transforms into non-functional filamentous aggregates in an inorganic phosphate (P i )-dependent manner in vitro. Here, we demonstrated that P i and reactive oxygen species (ROS) induce DJ-1 aggregation in Neuro2A and SH-SY5Y cells. Remarkably, tartrate treatment significantl...
Published on Oct 1, 2016in Nature Cell Biology17.73
Sanguk Yun5
Estimated H-index: 5
,
Madhusudhan Budatha11
Estimated H-index: 11
+ 6 AuthorsMartin A. Schwartz91
Estimated H-index: 91
Using a chimaeric integrin α5 (where the tail is replaced by that of α2), Yun et al. show that in endothelial cells, integrin α5 interacts with the cAMP-specific phosphodiesterase PDE4D5 to reduce cAMP levels and inflammation both in vitro and in vivo.
Published on Sep 1, 2016
Sanguk Yun5
Estimated H-index: 5
,
Madhusudhan Budatha11
Estimated H-index: 11
+ 6 AuthorsDaniel G. Anderson86
Estimated H-index: 86
Published on Mar 1, 2016in Journal of Clinical Investigation12.28
Nicolas Baeyens11
Estimated H-index: 11
,
Chirosree Bandyopadhyay8
Estimated H-index: 8
+ 2 AuthorsMartin A. Schwartz91
Estimated H-index: 91
Abstract Endothelial cells transduce the frictional force from blood flow (fluid shear stress) into biochemical signals that regulate gene expression and cell behavior via specialized mechanisms and pathways. These pathways shape the vascular system during development and during postnatal and adult life to optimize flow to tissues. The same pathways also contribute to atherosclerosis and vascular malformations. This Review covers recent advances in basic mechanisms of flow signaling and the invo...
Published on Oct 1, 2013in Current Opinion in Cell Biology8.23
Tyler D. Ross7
Estimated H-index: 7
(Yale University),
Brian Bg Coon4
Estimated H-index: 4
(Yale University)
+ 4 AuthorsMartin A. Schwartz91
Estimated H-index: 91
(Yale University)
Forces acting on cells govern many important regulatory events during development, normal physiology, and disease processes. Integrin-mediated adhesions, which transmit forces between the extracellular matrix and the actin cytoskeleton, play a central role in transducing effects of forces to regulate cell functions. Recent work has led to major insights into the molecular mechanisms by which these adhesions respond to forces to control cellular signaling pathways. We briefly summarize effects of...
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