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Nature Cell Biology
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#1Marina Vietri (University of Oslo)H-Index: 9
#2Sebastian W. Schultz (University of Oslo)H-Index: 11
Last. Eline Kip (University of Oslo)H-Index: 1
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The ESCRT-III membrane fission machinery maintains the integrity of the nuclear envelope. Although primary nuclei resealing takes minutes, micronuclear envelope ruptures seem to be irreversible. Instead, micronuclear ruptures result in catastrophic membrane collapse and are associated with chromosome fragmentation and chromothripsis, complex chromosome rearrangements thought to be a major driving force in cancer development. Here we use a combination of live microscopy and electron tomography, a...
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#2Dmytro PuchkovH-Index: 19
Last. Volker Haucke (FU: Free University of Berlin)H-Index: 54
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Lysosomes serve as cellular degradation and signalling centres that coordinate metabolism in response to intracellular cues and extracellular signals. Lysosomal capacity is adapted to cellular needs by transcription factors, such as TFEB and TFE3, which activate the expression of lysosomal and autophagy genes. Nuclear translocation and activation of TFEB are induced by a variety of conditions such as starvation, lysosome stress and lysosomal storage disorders. How these various cues are integrat...
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#1Adam BurtonH-Index: 5
#2Vincent Brochard (Université Paris-Saclay)H-Index: 15
Last. Hang Gyeong Chin (NEB: New England Biolabs)H-Index: 20
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Following fertilization in mammals, the gametes are reprogrammed to create a totipotent zygote, a process that involves de novo establishment of chromatin domains. A major feature occurring during preimplantation development is the dramatic remodelling of constitutive heterochromatin, although the functional relevance of this is unknown. Here, we show that heterochromatin establishment relies on the stepwise expression and regulated activity of SUV39H enzymes. Enforcing precocious acquisition of...
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#1Sara Zumerle (UNIPD: University of Padua)H-Index: 3
#2Andrea Alimonti (ETH Zurich)
Cellular senescence has been widely recognised for decades as a stable arrest of cell proliferation. A recent study identifies senescence establishment and maintenance as a dynamic and reversible process regulated by (in)activation of a predetermined enhancer landscape controlled by the pioneer transcription factor AP-1.
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#1Daniel Haensel (Stanford University)
#2Anthony E. Oro (Stanford University)H-Index: 40
Stem cells tightly link their metabolism to cell fate decisions; however, how cancers co-opt and bypass metabolic pathways for growth advantage remains unclear. New evidence in this issue highlights how cancer stem cells avoid epigenetically driven differentiation by shutting down endogenous serine synthesis and becoming serine auxotrophs.
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#1Luyan Cao (University of Paris)H-Index: 1
#2Amina Yonis (UCL: University College London)H-Index: 5
Last. Emma Ferber (London Centre for Nanotechnology)
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Cell shape is controlled by the submembranous cortex, an actomyosin network mainly generated by two actin nucleators: the Arp2/3 complex and the formin mDia1. Changes in relative nucleator activity may alter cortical organization, mechanics and cell shape. Here we investigate how nucleation-promoting factors mediate interactions between nucleators. In vitro, the nucleation-promoting factor SPIN90 promotes formation of unbranched filaments by Arp2/3, a process thought to provide the initial filam...
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#1Esther Arwert (Francis Crick Institute)H-Index: 1
#1Esther N. Arwert (Francis Crick Institute)H-Index: 10
Last. Erik Sahai (Francis Crick Institute)H-Index: 59
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#1Jia-Wei Hsu (Brigham and Women's Hospital)H-Index: 6
#2Ming Bai (Brigham and Women's Hospital)H-Index: 8
Last. Victor W. Hsu (Brigham and Women's Hospital)H-Index: 38
view all 9 authors...
Coat proteins have a central role in vesicular transport by binding to cargoes for their sorting into intracellular pathways. Cargo recognition is mediated by components of the coat complex known as adaptor proteins1–3. We previously showed that Arf-GAP with coil-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) functions as an adaptor for a clathrin coat complex that has a function in endocytic recycling4–6. Here, we show that the protein kinase Akt acts as a co-adaptor in this comple...
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#1Tobias Roider (Molecular Medicine Partnership Unit)H-Index: 1
#2Julian Seufert (DKFZ: German Cancer Research Center)H-Index: 3
Last. Peter-Martin Bruch (Molecular Medicine Partnership Unit)H-Index: 1
view all 26 authors...
Tumour heterogeneity encompasses both the malignant cells and their microenvironment. While heterogeneity between individual patients is known to affect the efficacy of cancer therapy, most personalized treatment approaches do not account for intratumor heterogeneity. We addressed this issue by studying the heterogeneity of nodal B cell lymphoma by single cell RNA-sequencing and transcriptome-informed flow cytometry. We identified transcriptionally distinct malignant subpopulations and compared ...
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#1Bilal N. Sheikh (MPG: Max Planck Society)H-Index: 12
#2Sukanya Guhathakurta (MPG: Max Planck Society)H-Index: 3
Last. Olga Bondareva (University of Freiburg)H-Index: 3
view all 27 authors...
Mutations in chromatin-modifying complexes and metabolic enzymes commonly underlie complex human developmental syndromes affecting multiple organs. A major challenge is to determine how disease-causing genetic lesions cause deregulation of homeostasis in unique cell types. Here we show that neural-specific depletion of three members of the non-specific lethal (NSL) chromatin complex—Mof, Kansl2 or Kansl3—unexpectedly leads to severe vascular defects and brain haemorrhaging. Deregulation of the e...
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