Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage
Abstract
The poor regenerative capacity of articular cartilage presents a major clinical challenge and may relate to a limited turnover of the cartilage collagen matrix. However, the collagen turnover rate during life is not clear, and it is debated whether osteoarthritis (OA) can influence it. Using the carbon-14 ((14)C) bomb-pulse method, life-long replacement rates of collagen were measured in tibial plateau cartilage from 23 persons born between 1935...
Paper Details
Title
Radiocarbon dating reveals minimal collagen turnover in both healthy and osteoarthritic human cartilage
Published Date
Jul 6, 2016
Volume
8
Issue
346
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