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Katja M. Heinemeier
University of Copenhagen
AnatomyEndocrinologySkeletal muscleTendonConnective tissue
72Publications
24H-index
2,301Citations
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Publications 72
Newest
#1Ching-Yan Chloé Yeung (UCPH: University of Copenhagen)
#2Peter Schjerling (UCPH: University of Copenhagen)H-Index: 53
Last. Michael Kjaer (UCPH: University of Copenhagen)H-Index: 92
view all 6 authors...
Purpose The discovery of musculoskeletal tissues, including muscle, tendons, and cartilage, as peripheral circadian clocks strongly implicates their role in tissue-specific homeostasis. Age-related dampening and misalignment of the tendon circadian rhythm and its outputs may be responsible for the decline in tendon homeostasis. It is unknown which entrainment signals are responsible for the synchronization of the tendon clock to the light–dark cycle.
Source
#1Antonis Giannopoulos (UCPH: University of Copenhagen)H-Index: 1
#2Rene B. Svensson (UCPH: University of Copenhagen)H-Index: 15
Last. S. Peter Magnusson (UCPH: University of Copenhagen)H-Index: 42
view all 8 authors...
Abstract Tendons transmit contractile muscular force to bone to produce movement, and it is believed cells can generate endogenous forces on the extracellular matrix to maintain tissue homeostasis. However, little is known about the direct mechanical measurement of cell-matrix interaction in cell-generated human tendon constructs. In this study we examined if cell-generated force could be detected and quantified in engineered human tendon constructs, and if glycosaminoglycans (GAGs) contribute t...
Source
#1Katja M. Heinemeier (UCPH: University of Copenhagen)H-Index: 24
#2Peter Schjerling (UCPH: University of Copenhagen)H-Index: 53
Last. Michael Kjaer (UCPH: University of Copenhagen)H-Index: 92
view all 6 authors...
Tendons are essential weight-bearing structures that are often affected by tendinopathy, which leads to pain and impaired mobility. In healthy Achilles tendons, no significant renewal of the weight-bearing collagen matrix seems to occur during adult life, but tendinopathy may lead to increased turnover. The carbon-14 ([14C]) bomb pulse method was used to measure lifelong replacement rates of collagen in tendinopathic and healthy Achilles tendons (tendinopathic: n = 25, born 1937–72. Healthy: n =...
4 CitationsSource
#1Katja M. Heinemeier (UCPH: University of Copenhagen)H-Index: 24
#2Tommy Frisgaard Øhlenschlæger (UCPH: University of Copenhagen)H-Index: 3
Last. Michael Kjaer (UCPH: University of Copenhagen)H-Index: 92
view all 7 authors...
Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat tendinopathy, but evidence for this treatment is lacking, and little is known regarding effects of NSAIDs on human tendinopathic tendon. This study investigated effects of NSAID treatment (ibuprofen) on human tendinopathic tendon, with changes in gene expression as the primary outcome, and tendon pain, function and blood flow as secondary outcomes. Twenty-six adults (16 male, 10 female) diagnosed with chronic Achilles tend...
5 CitationsSource
#1Rie Nygaard (UCPH: University of Copenhagen)H-Index: 12
#2Jacob Kildevang Jensen (UCPH: University of Copenhagen)H-Index: 3
Last. Michael Kjaer (UCPH: University of Copenhagen)H-Index: 92
view all 11 authors...
This study is the first of its kind to systematically investigate muscle biopsies from Ehlers-Danlos patients, focusing on muscle structure and function. These patients suffer from severe muscle symptoms, but in our study they show surprisingly normal muscle findings, which points toward indirect muscle symptoms originating from the surrounding connective tissue. These findings have basal physiological importance and implications for future physiotherapeutic treatment options for these patients.
Source
#1Adam El Mongy Jørgensen (UCPH: University of Copenhagen)H-Index: 1
#2Michael KjaerH-Index: 92
Last. Katja M. HeinemeierH-Index: 24
view all 3 authors...
Objective. The morphology of articular cartilage (AC) enables painless movement. Aging and mechanical loading are believed to influence development of osteoarthritis (OA), yet the connection remains unclear. Methods. This narrative review describes the current knowledge regarding this area, with the literature search made on PubMed using appropriate keywords regarding AC, age, and mechanical loading. Results. Following skeletal maturation, chondrocyte numbers decline while increasing senescence ...
19 CitationsSource
#1Pernilla Eliasson (Linköping University)H-Index: 17
#2Rene B. Svensson (UCPH: University of Copenhagen)H-Index: 15
Last. Katja M. Heinemeier (UCPH: University of Copenhagen)H-Index: 24
view all 7 authors...
Treatment with lipid-lowering drugs, statins, is common all over the world. Lately, the occurrence of spontaneous tendon ruptures or tendinosis have suggested a negative influence of statins upon tendon tissue. But how statins might influence tendons is not clear. In the present study, we investigated the effect of statin treatment on mechanical strength, cell proliferation, collagen content and gene expression pattern in a tendon-like tissue made from human tenocytes in vitro. Human tendon fibr...
3 CitationsSource
#1Christian Couppé (UCPH: University of Copenhagen)H-Index: 17
#2Rene B. Svensson (UCPH: University of Copenhagen)H-Index: 15
Last. Peter Schjerling (UCPH: University of Copenhagen)H-Index: 53
view all 9 authors...
Increased tendon cell nuclei density (TCND) has been proposed to induce tendon mechanical adaptations. However, it is unknown whether TCND is increased in tendon tissue after mechanical loading and whether such an increase can be quantified in a reliable manner. The aim of this study was to develop a reliable method for quantification of TCND and to investigate potential changes in TCND in rat Achilles tendons in response to 12 weeks of running. Eight adult male Sprague–Dawley rats ran (RUN) on ...
4 CitationsSource
#1Rene B. Svensson (UCPH: University of Copenhagen)H-Index: 15
#2Katja M. Heinemeier (UCPH: University of Copenhagen)H-Index: 24
Last. Stig Peter Magnusson (UCPH: University of Copenhagen)H-Index: 40
view all 5 authors...
Here, we review the literature on how tendons respond and adapt to ageing and exercise. With respect to aging, there are considerable changes early in life, but this seems to be maturation rather than aging per se. In vitro data indicate that aging is associated with a decreased potential for cell proliferation and a reduction in the number of stem/progenitor-like cells. Further, there is persuasive evidence that turnover in the core of the tendon after maturity is very slow or absent. Tendon fi...
35 CitationsSource
#1Katja M. Heinemeier (UCPH: University of Copenhagen)H-Index: 24
#2Peter Schjerling (UCPH: University of Copenhagen)H-Index: 53
Last. Michael Kjaer (UCPH: University of Copenhagen)H-Index: 92
view all 8 authors...
It has long been debated for many tissues in our bodies whether they are permanent or constantly refreshed as we go through life. Nuclear bomb testing in the 1950s and 1960s released a large amount of the carbon-14 isotope into the atmosphere, giving researchers the ability to determine the age and turnover of human tissues, ranging from the heart to the brain to, now, the cartilage. Heinemeier and colleagues used this so-called “14C bomb pulse” method to date cartilage from 23 individuals rangi...
39 CitationsSource
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