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Science Translational Medicine
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#1So-Yon Lim (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 14
#2Christa E. Osuna (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 9
Last. Saverio CapuanoH-Index: 28
view all 18 authors...
Zika virus infection in humans has been associated with serious reproductive and neurological complications. At present, no protective antiviral drug treatment is available. Here, we describe the testing and evaluation of the antiviral drug, galidesivir, against Zika virus infection in rhesus macaques. We conducted four preclinical studies in rhesus macaques to assess the safety, antiviral efficacy, and dosing strategies for galidesivir (BCX4430) against Zika virus infection. We treated 70 rhesu...
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#1Nathan Norton Ng (Stanford University)H-Index: 1
#2Avnesh S. Thakor (Stanford University)H-Index: 18
Interventional regenerative medicine (IRM) uses image-guided, minimally invasive procedures for the targeted delivery of stem cell–based therapies to regenerate, replace, or repair damaged organs. Although many cellular therapies have shown promise in the preclinical setting, clinical results have been suboptimal. Most intravenously delivered cells become trapped in the lungs and reticuloendothelial system, resulting in little therapy reaching target tissues. IRM aims to increase the efficacy of...
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#1Sonia Maciejewski (NIH: National Institutes of Health)
#2Tracy J. Ruckwardt (Vaccine Research Center)H-Index: 17
Last. Brian E. Fisher (Vaccine Research Center)
view all 30 authors...
The emergence of Zika virus (ZIKV) in the Americas stimulated the development of multiple ZIKV vaccine candidates. We previously developed two related DNA vaccine candidates encoding ZIKV structural proteins that were immunogenic in animal models and humans. We sought to identify neutralizing antibody (NAb) properties induced by each vaccine that correlated with protection in nonhuman primates (NHPs). Despite eliciting equivalent NAb titers in NHPs, these vaccines were not equally protective. Th...
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#1Emily J. Gallagher (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 22
Hyperinsulinemia and insulin receptor signaling allow cancer cells to evade cell competition.
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#1Peng Zhang (KU: University of Kansas)H-Index: 4
#2Xiaoqing Wu (KU: University of Kansas)H-Index: 11
Last. Yong Zeng (KU: University of Kansas)H-Index: 14
view all 7 authors...
Longitudinal cancer monitoring is crucial to clinical implementation of precision medicine. There is growing evidence indicating important functions of extracellular vesicles (EVs) in tumor progression and metastasis, including matrix remodeling via transporting matrix metalloproteases (MMPs). However, the clinical relevance of EVs remains largely undetermined, partially owing to challenges in EV analysis. Distinct from existing technologies mostly focused on characterizing molecular constituent...
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#1Shaon Sengupta (Children's Hospital of Philadelphia)H-Index: 5
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#1Madi Y. Cissé (University of Montpellier)H-Index: 2
#2Samuel Pyrdziak (University of Montpellier)H-Index: 1
Last. Giuseppe Arena (University of Montpellier)H-Index: 8
view all 19 authors...
Well-differentiated and dedifferentiated liposarcomas (LPSs) are characterized by a systematic amplification of the MDM2 oncogene, which encodes a key negative regulator of the p53 pathway. The molecular mechanisms underlying MDM2 overexpression while sparing wild-type p53 in LPS remain poorly understood. Here, we show that the p53-independent metabolic functions of chromatin-bound MDM2 are exacerbated in LPS and mediate an addiction to serine metabolism that sustains nucleotide synthesis and tu...
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The extent of lymphocyte infiltration controls cancer subclone divergence, and a single immune cold region can increase the risk of relapse.
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#1Anne-Kathrin Lutz (University of Ulm)H-Index: 3
#2Stefanie Pfaender (University of Ulm)H-Index: 6
Last. Federica Giona (University of Milan)H-Index: 1
view all 28 authors...
Heterozygous mutations of the gene encoding the postsynaptic protein SHANK3 are associated with syndromic forms of autism spectrum disorders (ASDs). One of the earliest clinical symptoms in SHANK3-associated ASD is neonatal skeletal muscle hypotonia. This symptom can be critical for the early diagnosis of affected children; however, the mechanism mediating hypotonia in ASD is not completely understood. Here, we used a combination of patient-derived human induced pluripotent stem cells (hiPSCs), ...
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#1Supriya Ravichandran (CBER: Center for Biologics Evaluation and Research)H-Index: 1
#2Elizabeth M. Coyle (CBER: Center for Biologics Evaluation and Research)H-Index: 8
Last. Surender Khurana (CBER: Center for Biologics Evaluation and Research)H-Index: 25
view all 9 authors...
Multiple vaccine candidates against SARS-CoV-2 based on viral spike protein are under development. However, there is limited information on the quality of antibody responses generated with these vaccine modalities. To better understand antibody responses induced by spike protein-based vaccines, we performed a qualitative study by immunizing rabbits with various SARS-CoV-2 spike protein antigens: S-ectodomain (S1+S2) (aa 16-1213), which lacks the cytoplasmic and transmembrane domains (CT-TM), the...
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