Science Translational Medicine
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Published on Feb 6, 2019in Science Translational Medicine 16.71
Dorian A Rosen1
Estimated H-index: 1
(University of Virginia),
Scott M. Seki3
Estimated H-index: 3
(University of Virginia)
+ 4 AuthorsAlban Gaultier24
Estimated H-index: 24
(University of Virginia)
Sepsis is an often deadly complication of infection in which systemic inflammation damages the vasculature, leading to tissue hypoperfusion and multiple organ failure. Currently, the standard of care for sepsis is predominantly supportive, with few therapeutic options available. Because of increased sepsis incidence worldwide, there is an urgent need for discovery of novel therapeutic targets and development of new treatments. The recently discovered function of the endoplasmic reticulum (ER) in...
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Published on Jan 16, 2019in Science Translational Medicine 16.71
Tríona Ní Chonghaile11
Estimated H-index: 11
(Royal College of Surgeons in Ireland)
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Published on Jan 2, 2019in Science Translational Medicine 16.71
Dingyin Tao14
Estimated H-index: 14
(Johns Hopkins University),
Brent McGill1
Estimated H-index: 1
(Johns Hopkins University)
+ 21 AuthorsAnne Elizabeth Jedlicka26
Estimated H-index: 26
(Johns Hopkins University)
A large proportion of ongoing malaria parasite transmission is attributed to low-density subclinical infections not readily detected by available rapid diagnostic tests (RDTs) or microscopy. Plasmodium falciparum gametocyte carriage is subclinical, but gametocytemic individuals comprise the parasite reservoir that leads to infection of mosquitoes and local transmission. Effective detection and quantification of these carriers can help advance malaria elimination strategies. However, no point-of-...
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Published on Feb 27, 2019in Science Translational Medicine 16.71
E.C.A. Nyns2
Estimated H-index: 2
(Leiden University Medical Center),
R. H. Poelma6
Estimated H-index: 6
(Delft University of Technology)
+ 9 AuthorsGuoqi Zhang27
Estimated H-index: 27
(Delft University of Technology)
Because of suboptimal therapeutic strategies, restoration of sinus rhythm in symptomatic atrial fibrillation (AF) often requires in-hospital delivery of high-voltage shocks, thereby precluding ambulatory AF termination. Continuous, rapid restoration of sinus rhythm is desired given the recurring and progressive nature of AF. Here, we present an automated hybrid bioelectronic system for shock-free termination of AF that enables the heart to act as an electric current generator for autogenous rest...
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Published on Jan 9, 2019in Science Translational Medicine 16.71
Mengfei Guo4
Estimated H-index: 4
(Huazhong University of Science and Technology),
Feng Wu4
Estimated H-index: 4
(Huazhong University of Science and Technology)
+ 19 AuthorsShuai Zhang1
Estimated H-index: 1
(Huazhong University of Science and Technology)
Cell membrane–derived microparticles (MPs), the critical mediators of intercellular communication, have gained much interest for use as natural drug delivery systems. Here, we examined the therapeutic potential of tumor cell–derived MPs (TMPs) in the context of malignant pleural effusion (MPE). TMPs packaging the chemotherapeutic drug methotrexate (TMPs-MTX) markedly restricted MPE growth and provided a survival benefit in MPE models induced by murine Lewis lung carcinoma and colon adenocarcinom...
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Published on Jan 23, 2019in Science Translational Medicine 16.71
Lu Yang4
Estimated H-index: 4
,
Yun Li8
Estimated H-index: 8
+ 1 AuthorsYuesheng Zhang36
Estimated H-index: 36
Resistance to current human epidermal growth factor receptor 2 (HER2) inhibitors, such as trastuzumab (Ttzm), is a major unresolved clinical problem in HER2-positive breast cancer (HER2-BC). Because HER2 remains overexpressed in drug-resistant HER2-BC cells, we investigated whether PEPD G278D can overcome the resistance. PEPD G278D is a recombinant enzymatically inactive mutant of human peptidase D, which strongly inhibits HER2 in cancer cells by binding to its extracellular domain. Here, we sho...
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Published on Jan 30, 2019in Science Translational Medicine 16.71
Niv Zmora13
Estimated H-index: 13
(Weizmann Institute of Science),
Eliran Soffer1
Estimated H-index: 1
(Weizmann Institute of Science),
Eran Elinav9
Estimated H-index: 9
(Weizmann Institute of Science)
Advances in microbiome research are spurring the development of new therapeutics for a variety of diseases, but translational challenges remain.
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Published on Mar 6, 2019in Science Translational Medicine 16.71
Gerard E. Kaiko18
Estimated H-index: 18
(University of Newcastle),
Feidi Chen (Washington University in St. Louis)+ 14 AuthorsKelli L. VanDussen10
Estimated H-index: 10
(Washington University in St. Louis)
There is a major unmet clinical need to identify pathways in inflammatory bowel disease (IBD) to classify patient disease activity, stratify patients that will benefit from targeted therapies such as anti–tumor necrosis factor (TNF), and identify new therapeutic targets. In this study, we conducted global transcriptome analysis to identify IBD-related pathways using colon biopsies, which highlighted the coagulation gene pathway as one of the most enriched gene sets in patients with IBD. Using th...
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Published on Jan 30, 2019in Science Translational Medicine 16.71
Many solid cancers contain dysfunctional immune microenvironments. Immune system modulators that initiate responses to foreign pathogens could be promising candidates for reigniting productive responses toward tumors. Interleukin-1 (IL-1) and IL-12 cytokine family members cooperate at barrier tissues after microbial invasion, in human inflammatory diseases, and in antitumoral immunity. IL-36γ, in classic alarmin fashion, acts in damaged tissues, whereas IL-23 centrally coordinates immune respons...
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Published on Feb 27, 2019in Science Translational Medicine 16.71
Adam C. Abraham1
Estimated H-index: 1
(Columbia University),
Shivam A. Shah3
Estimated H-index: 3
(Washington University in St. Louis)
+ 8 AuthorsLeesa M. Galatz40
Estimated H-index: 40
(Mount Sinai Hospital)
Tendon disorders represent the most common musculoskeletal complaint for which patients seek medical attention; inflammation drives tendon degeneration before tearing and impairs healing after repair. Clinical evidence has implicated the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway as a correlate of pain-free return to function after surgical repair. However, it is currently unknown whether this response is a reaction to or a driver of pathology. Therefore, we a...
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