Original paper
Single-Particle Tracking of HIV-1 Virions Bearing an Extra-Viral Fluorescent pH Sensor Reveals Viral Entry occurs after Trafficking to an Acidic Cellular Compartment
Abstract
The HIV-1 infectious cycle begins with viral glycoprotein mediated fusion with the host cell membrane and subsequent entry of the viral capsid to the host cytosol. It has been proposed that HIV-1 fusion and productive entry occur at the plasma membrane (PM) because functionality of the HIV-1 fusion glycoprotein (Env) is pH-independent. Further supporting this hypothesis are the observations that HIV-1 mediates fusion between adjacent cells and...
Paper Details
Title
Single-Particle Tracking of HIV-1 Virions Bearing an Extra-Viral Fluorescent pH Sensor Reveals Viral Entry occurs after Trafficking to an Acidic Cellular Compartment
Published Date
Feb 1, 2016
Journal
Volume
110
Issue
3
Pages
249a - 249a
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Notes
History