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Gray and White Matter Contributions to Cognitive Frontostriatal Deficits in Non-Demented Parkinson's Disease.

Published on Jan 19, 2016in PLOS ONE2.78
· DOI :10.1371/journal.pone.0147332
Catherine C. Price22
Estimated H-index: 22
(UF: University of Florida),
Jared J. Tanner7
Estimated H-index: 7
(UF: University of Florida)
+ 7 AuthorsDawn Bowers45
Estimated H-index: 45
(UF: University of Florida)
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Abstract
Objective This prospective investigation examined: 1) processing speed and working memory relative to other cognitive domains in non-demented medically managed idiopathic Parkinson’s disease, and 2) the predictive role of cortical/subcortical gray thickness/volume and white matter fractional anisotropy on processing speed and working memory. Methods Participants completed a neuropsychological protocol, Unified Parkinson’s Disease Rating Scale, brain MRI, and fasting blood draw to rule out vascular contributors. Within group a priori anatomical contributors included bilateral frontal thickness, caudate nuclei volume, and prefrontal white matter fractional anisotropy. Results Idiopathic Parkinson’s disease (n = 40; Hoehn & Yahr stages 1–3) and non-Parkinson’s disease ‘control’ peers (n = 40) matched on demographics, general cognition, comorbidity, and imaging/blood vascular metrics. Cognitively, individuals with Parkinson’s disease were significantly more impaired than controls on tests of processing speed, secondary deficits on working memory, with subtle impairments in memory, abstract reasoning, and visuoperceptual/spatial abilities. Anatomically, Parkinson’s disease individuals were not statistically different in cortical gray thickness or subcortical gray volumes with the exception of the putamen. Tract Based Spatial Statistics showed reduced prefrontal fractional anisotropy for Parkinson’s disease relative to controls. Within Parkinson’s disease, prefrontal fractional anisotropy and caudate nucleus volume partially explained processing speed. For controls, only prefrontal white matter was a significant contributor to processing speed. There were no significant anatomical predictors of working memory for either group. Conclusions Caudate nuclei volume and prefrontal fractional anisotropy, not frontal gray matter thickness, showed unique and combined significance for processing speed in Parkinson’s disease. Findings underscore the relevance for examining gray-white matter interactions and also highlight clinical processing speed metrics as potential indicators of early cognitive impairment in PD.
  • References (109)
  • Citations (16)
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References109
Newest
Published on Jul 1, 2016in Brain Structure & Function3.62
Ksenia A. Kuznetsova1
Estimated H-index: 1
(Edin.: University of Edinburgh),
Susana Muñoz Maniega31
Estimated H-index: 31
(Edin.: University of Edinburgh)
+ 6 AuthorsMark E. Bastin49
Estimated H-index: 49
(Edin.: University of Edinburgh)
Cognitive decline, especially the slowing of information processing speed, is associated with normal ageing. This decline may be due to brain cortico-cortical disconnection caused by age-related white matter deterioration. We present results from a large, narrow age range cohort of generally healthy, community-dwelling subjects in their seventies who also had their cognitive ability tested in youth (age 11 years). We investigate associations between older age brain white matter structure, severa...
Published on Mar 1, 2016in Cerebral Cortex5.44
Clarisse Aichelburg2
Estimated H-index: 2
(UPMC: Pierre-and-Marie-Curie University),
Marika Urbanski14
Estimated H-index: 14
+ 3 AuthorsEmmanuelle Volle9
Estimated H-index: 9
(UPMC: Pierre-and-Marie-Curie University)
Analogical reasoning is critical for making inferences and adapting to novelty. It can be studied experimentally using tasksthat require creating similarities between situations or concepts, i.e., when their constituent elements share a similar organization or structure. Brain correlates of analogical reasoning have mostly been explored using functional imaging that has highlighted the involvement of the left rostrolateral prefrontal cortex (rlPFC) in healthy subjects. However, whether inter-ind...
Published on Nov 1, 2015in Brain Structure & Function3.62
Aurélie Fitoussi5
Estimated H-index: 5
(University of Bordeaux),
Catherine Le Moine21
Estimated H-index: 21
(University of Bordeaux)
+ 4 AuthorsFrançoise Dellu-Hagedorn13
Estimated H-index: 13
(University of Bordeaux)
A major challenge of decision-making research in recent years has been to develop models of poor decision-making to identify its neural bases. Toward this goal, we developed a Rat Gambling Task that discerns good and poor decision-makers in a complex and conflicting situation such as the human Iowa Gambling Task. Nothing is known about the role of the monoaminergic modulatory systems in shaping these phenotypes. Moreover, functional and temporal contributions of brain areas during poor compared ...
Published on Jul 24, 2015in PLOS ONE2.78
Jared J. Tanner7
Estimated H-index: 7
(UF: University of Florida),
Thomas H. Mareci34
Estimated H-index: 34
(UF: University of Florida)
+ 3 AuthorsCatherine C. Price22
Estimated H-index: 22
(UF: University of Florida)
Objective The current investigation examined verbal memory in idiopathic non-dementia Parkinson’s disease and the significance of the left entorhinal cortex and left entorhinal-retrosplenial region connections (via temporal cingulum) on memory impairment in Parkinson’s disease.
Published on Jul 14, 2015in PLOS ONE2.78
Luis M. Colon-Perez8
Estimated H-index: 8
(UF: University of Florida),
Caitlin Spindler1
Estimated H-index: 1
(UF: University of Florida)
+ 6 AuthorsThomas H. Mareci34
Estimated H-index: 34
(UF: University of Florida)
High spatial and angular resolution diffusion weighted imaging (DWI) with network analysis provides a unique framework for the study of brain structure in vivo. DWI-derived brain connectivity patterns are best characterized with graph theory using an edge weight to quantify the strength of white matter connections between gray matter nodes. Here a dimensionless, scale-invariant edge weight is introduced to measure node connectivity. This edge weight metric provides reasonable and consistent valu...
Published on May 1, 2015in Brain Structure & Function3.62
Claudia Diana Wurster3
Estimated H-index: 3
(University of Ulm),
Heiko Graf7
Estimated H-index: 7
(University of Ulm)
+ 3 AuthorsAxel Riecker30
Estimated H-index: 30
(University of Ulm)
Functional imaging demonstrated hemodynamic activation within specific brain areas that contribute to frequency-dependent movement control. Previous investigations demonstrated a linear relationship between movement and hemodynamic response rates within cortical regions, whereas the basal ganglia displayed an inverse neural activation pattern. We now investigated neural correlates of frequency-related finger movements in patients with Parkinson’s disease (PD) to further elucidate the neurofuncti...
Published on Mar 1, 2015in Cortex4.28
Sébastien Hélie12
Estimated H-index: 12
(Purdue University),
Shawn W. Ell13
Estimated H-index: 13
(UMaine: University of Maine),
F. Gregory Ashby52
Estimated H-index: 52
(UCSB: University of California, Santa Barbara)
Abstract This article focuses on the interaction between the basal ganglia (BG) and prefrontal cortex (PFC). The BG are a group of nuclei at the base of the forebrain that are highly connected with cortex. A century of research suggests that the role of the BG is not exclusively motor, and that the BG also play an important role in learning and memory. In this review article, we argue that one important role of the BG is to train connections between posterior cortical areas and frontal cortical ...
Published on Feb 1, 2015in JAMA Neurology12.32
Nicolaas I. Bohnen47
Estimated H-index: 47
(UM: University of Michigan),
Roger L. Albin68
Estimated H-index: 68
(UM: University of Michigan)
+ 5 AuthorsKirk A. Frey67
Estimated H-index: 67
(UM: University of Michigan)
Importance Little is known about the relative contributions of multisystem degenerative processes across the spectrum of predemented cognitive decline in Parkinson disease (PD). Objective To investigate the relative frequency of caudate nucleus dopaminergic and forebrain cholinergic deficits across a spectrum of cognitively impaired patients with PD to explore their relative, individual, and combined contributions to cognitive impairment in PD. Design, Setting, and Participants A cross-sectional...
Published on Jan 1, 2015in Neurobiology of Aging4.40
Federico Nemmi13
Estimated H-index: 13
(University of Toulouse),
Umberto Sabatini34
Estimated H-index: 34
+ 1 AuthorsPatrice Péran22
Estimated H-index: 22
(University of Toulouse)
Abstract Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra pars compacta, inducing dopaminergic depletion in the striatum. Recently, subcortical nuclei shape analysis based on T1 imaging has been used in PD pathology. The present study aimed to test the hypothesis that changes in local volume detectable with T1-weighted imaging are concomitant with PD and may be used as biomarkers. We compared 21 PD patients and 20 control subjects using gray matte...
Published on Jan 1, 2015in Neuropsychologia2.87
Laura Babcock5
Estimated H-index: 5
(SISSA: International School for Advanced Studies),
Antonino Vallesi25
Estimated H-index: 25
(UNIPD: University of Padua)
Inductive reasoning is an everyday process that allows us to make sense of the world by creating rules from a series of instances. Consistent with accounts of process-based fractionations of the prefrontal cortex (PFC) along the left–right axis, inductive reasoning has been reliably localized to left PFC. However, these results may be confounded by the task domain, which is typically verbal. Indeed, some studies show that right PFC activation is seen with spatial tasks. This study used fMRI to e...
Cited By16
Newest
Published on Jul 25, 2018in Brain Imaging and Behavior3.42
Rachael C. Cvejic1
Estimated H-index: 1
(UNSW: University of New South Wales),
Darren R. Hocking16
Estimated H-index: 16
(La Trobe University)
+ 5 AuthorsJulian N. Trollor34
Estimated H-index: 34
(UNSW: University of New South Wales)
Fragile X-associated tremor ataxia syndrome is an inherited neurodegenerative disorder caused by premutation expansions (55–200 CGG repeats) of the FMR1 gene. There is accumulating evidence to suggest that early cognitive and brain imaging signs may be observed in some premutation carriers without motor signs of FXTAS, but few studies have examined the relationships between subcortical brain volumes and cognitive performance in this group. This study examined the relationships between caudate vo...
Published on Apr 1, 2019in Biological Psychiatry11.50
Bret R. Rutherford18
Estimated H-index: 18
(Columbia University),
Mark Slifstein53
Estimated H-index: 53
(SBU: Stony Brook University)
+ 8 AuthorsEmily Valente
Abstract Background A high-risk subgroup of older patients with depression has slowed processing and gait speeds. This study examined whether carbidopa/levodopa (L-DOPA) monotherapy increased dopamine availability, increased processing/gait speed, and relieved depressive symptoms. Methods Adult outpatients with depression >59 years old underwent baseline [ 11 C]raclopride positron emission tomography followed by open L-DOPA for 3 weeks (1 week each of 150 mg, 300 mg, and 450 mg). Generalized est...
Published on Mar 28, 2019
Published on Mar 1, 2019in Brain Research2.93
Xuezhu Cai (NU: Northeastern University), Ju Qiao1
Estimated H-index: 1
(NU: Northeastern University)
+ 7 AuthorsCraig F. Ferris55
Estimated H-index: 55
(NU: Northeastern University)
Abstract Parkinson’s Disease (PD) is the second most common neurodegenerative disorder, with 60,000 new cases diagnosed each year in the US. There are multiple animal models of PD that attempt to mimic the effects of the disease through genetic alteration. Combined with advanced imaging techniques, these animal models are critical in tracking the neurobiological and behavioral aspects of disease progression and identifying early biomarkers of PD. PTEN-induced putative kinase 1 (PINK1) is a mitoc...
Published on Jan 1, 2019in NeuroImage: Clinical3.94
Benzi M. Kluger20
Estimated H-index: 20
(University of Colorado Denver),
Qing Zhao1
Estimated H-index: 1
(UF: University of Florida)
+ 6 AuthorsCatherine C. Price22
Estimated H-index: 22
(UF: University of Florida)
Abstract Fatigue is one of the most common and disabling nonmotor symptoms seen in Parkinson's disease (PD) and is also commonly seen in healthy older adults. Our understanding of the etiology of fatigue in older adults with or without PD is limited and it remains unclear whether fatigue in PD is specifically related to PD pathology. The objective of this study was thus to determine whether fatigue in PD was associated with structural changes in gray or white matter and explore whether these cha...
Published on Jul 26, 2018in Frontiers in Neurology2.63
Maryam Haghshomar2
Estimated H-index: 2
(Tehran University of Medical Sciences),
Mahsa Dolatshahi2
Estimated H-index: 2
(Tehran University of Medical Sciences)
+ 3 AuthorsMohammad Hadi Aarabi6
Estimated H-index: 6
(Tehran University of Medical Sciences)
Parkinson's disease (PD) is a neurodegenerative disorder accompanied by a series of pathological mechanisms which contribute to a variety of motor and non-motor symptoms. Recently, there has been an increasing interest in structural diffusion tensor imaging (DTI) in PD which has shed light on our understanding of structural abnormalities underlying PD symptoms or its associations with pathological mechanisms in PD. One of the white matter tracts whose alterations have been observed in PD and may...
Published on Jun 1, 2018in Brain Structure & Function3.62
Ima Trempler2
Estimated H-index: 2
,
Ellen Binder5
Estimated H-index: 5
+ 5 AuthorsRicarda Ines Schubotz34
Estimated H-index: 34
Parkinson’s disease (PD), which is caused by degeneration of dopaminergic neurons in the midbrain, results in a heterogeneous clinical picture including cognitive decline. Since the phasic signal of dopamine neurons is proposed to guide learning by signifying mismatches between subjects’ expectations and external events, we here investigated whether akinetic-rigid PD patients without mild cognitive impairment exhibit difficulties in dealing with either relevant (requiring flexibility) or irrelev...
Published on Jan 1, 2018
Patrice Péran22
Estimated H-index: 22
(University of Toulouse),
Federico Nemmi13
Estimated H-index: 13
(University of Toulouse),
Gaetano Barbagallo8
Estimated H-index: 8
Published on Sep 27, 2017
Luis M. Colon-Perez8
Estimated H-index: 8
(UF: University of Florida),
Jared J. Tanner7
Estimated H-index: 7
(UF: University of Florida)
+ 3 AuthorsCatherine C. Price22
Estimated H-index: 22
(UF: University of Florida)
In this study, we investigate the organization of the structural connectome in cognitively well participants with Parkinson’s disease (PD-Well; n = 31) and a subgroup of participants with Parkinson’s disease who have amnestic disturbances (PD-MI; n = 9). We explore correlations between connectome topology and vulnerable cognitive domains in Parkinson’s disease relative to non-Parkinson’s disease peers (control, n = 40). Diffusion-weighted MRI data and deterministic tractography were used to gene...
Published on Apr 13, 2017in Frontiers in Neurology2.63
Jared J. Tanner7
Estimated H-index: 7
(UF: University of Florida),
Nikolaus R. McFarland21
Estimated H-index: 21
(UF: University of Florida),
Catherine C. Price22
Estimated H-index: 22
(UF: University of Florida)
BACKGROUND: Analyses of subcortical gray structure volumes in non-demented idiopathic Parkinson’s disease (PD) often but not always show volume loss of the putamen, caudate nucleus, nucleus accumbens, and hippocampus. There is building evidence that structure morphometry might be more sensitive to disease-related processes than volume. OBJECTIVE: To assess morphometric differences of subcortical structures (putamen, caudate nucleus, thalamus, globus pallidus, nucleus accumbens, amygdala) as well...
View next paperLongitudinal Study of Gray Matter Changes in Parkinson Disease