Virus infections differentially modulate the cell cycle state and functionality of dormant long-term hematopoietic stem cells in vivo

Type I interferon (IFN-I) has recently been identified as an activator of dormant long-term hematopoietic stem cells (LT-HSCs) in murine bone marrow (BM). So far this phenomenon has primarily been addressed by administering IFN-I inducing ligands like poly(I:C) or recombinant IFN-I, whereas the effect of IFN-I responses induced by virus infections has less intensively been studied. We therefore firstly infected wildtype mice (WT) with the...