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Christoph Hirche
German Cancer Research Center
5Publications
2H-index
149Citations
Publications 5
Newest
Published on Dec 1, 2019in Nature Communications11.88
Pia-Katharina Tegtmeyer1
Estimated H-index: 1
,
Julia Spanier8
Estimated H-index: 8
+ 10 AuthorsStefan Lienenklaus27
Estimated H-index: 27
Cytomegalovirus is a DNA-encoded β-herpesvirus that induces STING-dependent type 1 interferon responses in macrophages and uses myeloid cells as a vehicle for dissemination. Here we report that STING knockout mice are as resistant to murine cytomegalovirus (MCMV) infection as wild-type controls, whereas mice with a combined Toll-like receptor/RIG-I-like receptor/STING signaling deficiency do not mount type 1 interferon responses and succumb to the infection. Although STING alone is dispensable f...
Published on Dec 7, 2017in Blood16.56
Simon Haas10
Estimated H-index: 10
(DKFZ: German Cancer Research Center),
Christoph Hirche2
Estimated H-index: 2
(DKFZ: German Cancer Research Center)
+ 11 AuthorsMichael D. Milsom7
Estimated H-index: 7
(DKFZ: German Cancer Research Center)
Mature blood and immune cells show broad inter- and intra-cell type-specific heterogeneity with respect to metabolic activity, gene expression patterns, differentiation capacity and responsiveness to cytokines such as interferons (IFNs). This diversity is of crucial importance to maintain the capacity of the immune system to appropriately react to a wide range of pathogenic insults, thereby mediating protective immunity. However, it remains poorly understood how such heterogeneity is generated a...
Published on Jun 1, 2017in Cell Reports7.82
Christoph Hirche2
Estimated H-index: 2
(MHH: Hannover Medical School),
Theresa Frenz10
Estimated H-index: 10
(MHH: Hannover Medical School)
+ 15 AuthorsChintan Chhatbar5
Estimated H-index: 5
(MHH: Hannover Medical School)
Summary Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). However, this effect remains poorly investigated in the context of IFN-I-inducing virus infections. Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCMV) infection induce LT-HSC activation that substantially differs from the effects triggered upon injection of synthetic IFN-I-inducing agents. In both infections, inflammatory responses had to...
Published on Apr 1, 2017in Nature Cell Biology17.73
Lars Velten4
Estimated H-index: 4
,
Simon Haas10
Estimated H-index: 10
(DKFZ: German Cancer Research Center)
+ 14 AuthorsDaniel Nowak19
Estimated H-index: 19
(Heidelberg University)
Velten et al. use single-cell transcriptomics and functional data to map the early lineage commitment of human haematopoietic stem cells as a continuous process of cells passing through transitory states rather than demarcating discrete progenitors.
Published on Nov 1, 2015in Cytokine3.08
Pia-Katharina Tegtmeyer1
Estimated H-index: 1
,
Julia Spanier8
Estimated H-index: 8
+ 5 AuthorsUlrich Kalinke35
Estimated H-index: 35
The cytomegalovirus (CMV), a member of the beta-herpesvirus family, is widely spread among the world population and causes lifelong latent infections, which can lead to severe diseases in immunocompromised patients. Therefore, it is important to understand the interplay between different immune mechanisms that are essential for the control of CMV infection. To dissect the role of different recognition platforms, MyD88Trif−/− and Cardif−/− mice devoid of TLR- or RLH-dependent signaling, respectiv...
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