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Experimental Hematology
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2.46
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9113
Papers 9065
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#1Marcus Høy Hansen (University of Southern Denmark)
#2Oriane Cédile (University of Southern Denmark)H-Index: 4
Last. Eigil Kjeldsen (Aarhus University Hospital)H-Index: 15
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Abstract Mantle Cell lymphoma (MCL) is a tumor with poor prognosis. A few studies have examined the molecular landscape by next generation sequencing and provided valuable insights into recurrent lesions driving this heterogeneous cancer. However, none have attempted to cross-link the individual genomic and transcriptomic profile in sorted MCL cells in order to perform individual molecular characterizations of the lymphomas. Such approaches are relevant as MCL is heterogenous by nature, and thor...
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#1Oluwabukola T. Gbotosho (University of Pittsburgh)
#2Maria G. Kapetanaki (University of Pittsburgh)H-Index: 11
Last. Gregory J. Kato (University of Pittsburgh)H-Index: 54
view all 9 authors...
Abstract Erythropoiesis in the bone marrow and spleen depends upon intricate interactions between the resident macrophages and erythroblasts. Our study focuses on identifying the role of the Nuclear Factor Erythroid 2-related factor 2 (Nrf2) during recovery from stress erythropoiesis. To that end, we induced stress erythropoiesis in Nrf2+/+ and Nrf2 null mice and evaluated macrophage subsets known to support erythropoiesis and erythroid cell populations. Our results confirm macrophage and erythr...
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#1Yoshiaki ChinenH-Index: 9
#2Taku TsukamotoH-Index: 4
Last. Yuji ShimuraH-Index: 11
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Abstract Cyclin D1 (CCND1) overexpression is an early and unifying oncogenic event in mantle cell lymphoma (MCL) and multiple myeloma (MM) with chromosome 11q13 abnormalities. Herein, we report newly discovered transcript variants of the CCND1 gene in MCL and MM cells with chromosome 11q13 abnormalities. These transcript variants, designated CCND1.tv., covered the full-length coding region of CCND1 with longer 5′-UTR of CCND1, and occasionally contained a novel exon. CCND1.tv. was specifically d...
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#1Joshua Tay (Translational Research Institute)
#1Joshua TayH-Index: 2
Last. Jean-Pierre LevesqueH-Index: 39
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Abstract The erythroblastic island (EBI) is a multicellular structure forming an erythropoietic niche consisting of a central macrophage surrounded by a rosette of maturing erythroblasts. Since their discovery more than 60 years ago, simultaneous quantification and visualization of EBIs remains difficult. Although flow cytometry enables high throughput quantification of cell aggregates co-expressing macrophage and erythroblast markers, it cannot visually confirm whether the aggregates are genuin...
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Abstract Clonal hematopoiesis is a common premalignant condition defined by the abnormal expansion of clonally derived hematopoietic stem cells carrying somatic mutations in leukemia-associated genes. Apart from increasing age, this phenomenon occurs with higher frequency in individuals with lymphoid or solid tumors and is associated with exposures to genotoxic stress. Clonal hematopoiesis in this context confers a greater risk for developing therapy-related myeloid neoplasms and appears to cont...
1 CitationsSource
#1Eraj Shafiq Khokhar (UMaine: University of Maine)
#2Sneha BorikarH-Index: 2
Last. Jennifer J. Trowbridge (UMaine: University of Maine)
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Abstract Aged hematopoietic stem cells (HSCs) undergo biased lineage priming and differentiation toward production of myeloid cells. A comprehensive understanding of gene regulatory mechanisms causing HSC aging is needed to devise new strategies to sustainably improve immune function in aged individuals. Here, a focused shRNA screen of epigenetic factors reveals that the histone acetyltransferase Kat6b regulates myeloid cell production from hematopoietic progenitor cells. Within the stem and pro...
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#1Henry Lee-Six (Wellcome Trust Sanger Institute)H-Index: 5
#2David G. Kent (University of Cambridge)H-Index: 24
Abstract Despite decades of progress in our understanding of hematopoiesis through the study of animal models and transplantation in humans, investigating physiological human hematopoiesis directly has remained challenging. Questions on the clonal structure of the human hematopoietic stem cell (HSC) pool, such as “how many HSCs are there?” and “do all HSC clones actively produce all blood cell types in equal proportions?” have remained open. These questions have inherent value for understanding ...
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#1Romy Kronstein-Wiedemann (TUD: Dresden University of Technology)H-Index: 1
#2Onny Klop (Biomedical Primate Research Centre)H-Index: 1
Last. Erica M. Pasini (Biomedical Primate Research Centre)H-Index: 14
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Abstract Establishing an in vitro "red blood cell matrix" that would allow uninterrupted access to a stable, homogeneous reticulocyte population would facilitate the establishment of continuous, long-term in vitro Plasmodium vivax blood stage cultures. In this study, we have explored the suitability of the erythroleukemia K562 cell line as a continuous source of such reticulocytes and have investigated regulatory factors behind the terminal differentiation (and enucleation, in particular) of thi...
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#1Miguel GanuzaH-Index: 3
#2Trent HallH-Index: 3
Last. Shannon McKinney-FreemanH-Index: 14
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Abstract Hematopoietic stem and progenitor cells (HSPCs) govern the daily expansion and turnover of billions of specialized blood cells. Given their clinical utility, much effort has been made towards understanding the dynamics of hematopoietic production from this pool of stem cells. An understanding of HSC clonal dynamics during blood ontogeny could yield important insights into hematopoietic regulation, especially during aging and repeated exposure to hematopoietic stress; insults that may pr...
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#1Kai Wang (Albert Einstein College of Medicine)H-Index: 1
#2Zi Yan (Albert Einstein College of Medicine)H-Index: 2
Last. Eric E. Bouhassira (Albert Einstein College of Medicine)H-Index: 37
view all 6 authors...
Summary Characterization of human cells that sustain blood cell production lifelong has historically been inferred from phenotypically defined subsets of cells assayed in vitro, in transplanted immunodeficient mice, or in patients transplanted with genetically marked cells. These approaches have led to the concept of a persistent complex hierarchical process of differentiation divisions originating from a rare population of CD34+CD38-CD45RA-CD90+CD49f+ cells with an average self-renewal potentia...
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Top fields of study
Haematopoiesis
Molecular biology
Immunology
Bone marrow
Biology