O3-13-06: Targeted re-sequencing of sorl1 in early-onset Alzheimer's dementia: The european early onset dementia consortium

The sortilin-related receptor 1 (SORL1) gene has been implicated in increased susceptibility to Alzheimer's disease (AD), but also in autosomal dominant early-onset AD (EOAD). At least one missense mutation has been reported to segregate with EOAD. Here we report a large-scale investigation of the contribution of genetic variability in SORL1 to EOAD in a European EOAD cohort. We performed massive parallel amplicon-based re-sequencing of the full...