RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits

Alzheimer’s disease (AD) is the most common form of dementia in the elderly. It is generally believed that β-amyloidogenesis, tau-hyperphosphorylation and synaptic loss underlie cognitive decline in AD. Rps23rg1 , a functional retroposed mouse gene, has been shown to reduce Alzheimer’s β-amyloid (Aβ) production and tau phosphorylation. In this study, we have identified its human homolog and demonstrated that RPS23RG1 regulates synaptic...