Exploring and exploiting the systemic effects of deregulated replication licensing
Abstract
Maintenance and accurate propagation of the genetic material are key features for physiological development and wellbeing. The replication licensing machinery is crucial for replication precision as it ensures that replication takes place once per cell cycle. Thus, the expression status of the components comprising the replication licensing apparatus is tightly regulated to avoid re-replication; a form of replication stress that leads to genomic...
Paper Details
Title
Exploring and exploiting the systemic effects of deregulated replication licensing
Published Date
Jun 1, 2016
Journal
Volume
37-38
Pages
3 - 15
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