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Eirini-Stavroula Komseli
National and Kapodistrian University of Athens
5Publications
3H-index
84Citations
Publications 5
Newest
#1Eirini-Stavroula Komseli (UoA: National and Kapodistrian University of Athens)H-Index: 3
#2Ioannis S. Pateras (UoA: National and Kapodistrian University of Athens)H-Index: 19
Last.Vassilis G. Gorgoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
view all 21 authors...
Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least in its initial phases, an anti-tumor response that needs to be circumvented for cancer to progress. Micro-RNAs, a subclass of regulatory, non-coding RNAs, participate in senescence regulation. At the subcellular level micro-RNAs, similar to proteins, have been shown to traffic between organelles influencing cellular behavior. The differentia...
#1Theodoros G. Petrakis (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Eirini-Stavroula Komseli (UoA: National and Kapodistrian University of Athens)H-Index: 3
Last.Vassilis G. Gorgoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
view all 12 authors...
#1Alberto Moreno (Dund.: University of Dundee)H-Index: 15
#2Jamie T. Carrington (Dund.: University of Dundee)H-Index: 2
Last.J. Julian Blow (Dund.: University of Dundee)H-Index: 60
view all 9 authors...
To prevent rereplication of genomic segments, the eukaryotic cell cycle is divided into two nonoverlapping phases. During late mitosis and G1 replication origins are “licensed” by loading MCM2-7 double hexamers and during S phase licensed replication origins activate to initiate bidirectional replication forks. Replication forks can stall irreversibly, and if two converging forks stall with no intervening licensed origin—a “double fork stall” (DFS)—replication cannot be completed by conventional...
#1Theodoros G. Petrakis (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Eirini-Stavroula Komseli (UoA: National and Kapodistrian University of Athens)H-Index: 3
Last.Vassilis G. Gorgoulis (UoA: National and Kapodistrian University of Athens)H-Index: 47
view all 12 authors...
Maintenance and accurate propagation of the genetic material are key features for physiological development and wellbeing. The replication licensing machinery is crucial for replication precision as it ensures that replication takes place once per cell cycle. Thus, the expression status of the components comprising the replication licensing apparatus is tightly regulated to avoid re-replication; a form of replication stress that leads to genomic instability, a hallmark of cancer. In the present ...
#1Eirini-Stavroula Komseli (UoA: National and Kapodistrian University of Athens)H-Index: 3
#2Fabiola Sesti (UoA: National and Kapodistrian University of Athens)H-Index: 2
Last.Ιωάννης Π. Τρουγκάκος (UoA: National and Kapodistrian University of Athens)H-Index: 32
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The maintenance of biomolecules functionality is essential for the assurance of cellular homeostasis. At the proteome level this is achieved by the action of a modular, yet integrated subcellular compartment-specific system which ensures proteome quality control and it is called the proteostasis network (PN). PN is orchestrated by a plethora of different mechanisms and complex protein machines aiming to respond to stressors, recognize and either rescue (via the action of chaperones) or degrade u...
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