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Vassilis G. Gorgoulis
National and Kapodistrian University of Athens
192Publications
47H-index
11.8kCitations
Publications 194
Newest
#1Panagiotis Vasileiou (UoA: National and Kapodistrian University of Athens)H-Index: 10
#2Gkikas Magiorkinis (UoA: National and Kapodistrian University of Athens)H-Index: 22
Last.Vassilis G. GorgoulisH-Index: 47
view all 4 authors...
Abstract The outburst of computing power and the advent of high-throughput technologies facilitated medicine to enter the era of systems approach. The basic principle of systems medicine is that the human organism is a mosaic of interacting subnetworks. In this regard, analytic methods should account for this multidimensional and dynamic nature of interdependence. Based on various computational models and novel mathematical methodologies, analytic methods in systems medicine are designed to hand...
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Summary A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a personalized basis. Using a pharmacogenomics database of 1,001 cancer cell lines, we trained deep neural networks for prediction of drug response and assessed their performance on multiple clinical cohorts. We demonstrate that deep neural networks outperform the current state in machine learning frameworks. We provide a proof of concept for the use of deep neural network-based frameworks to ai...
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Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellula...
5 CitationsSource
#1Riccardo VanzoH-Index: 1
#2Jirina Bartkova (Science for Life Laboratory)H-Index: 54
Last.Bartek Jiri (Science for Life Laboratory)H-Index: 97
view all 11 authors...
Autophagy is an evolutionarily conserved process that captures aberrant intracellular proteins and/or damaged organelles for delivery to lysosomes, with implications for cellular and organismal homeostasis, aging and diverse pathologies, including cancer. During cancer development, autophagy may play both tumour-supporting and tumour-suppressing roles. Any relationships of autophagy to the established oncogene-induced replication stress (RS) and the ensuing DNA damage response (DDR)-mediated ant...
1 CitationsSource
#1Panagiotis Vasileiou (UoA: National and Kapodistrian University of Athens)H-Index: 10
#2Konstantinos Evangelou (UoA: National and Kapodistrian University of Athens)H-Index: 18
Last.Sophia Havaki (UoA: National and Kapodistrian University of Athens)H-Index: 8
view all 10 authors...
Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a co...
1 CitationsSource
#1Konstantinos Vougas (UoA: National and Kapodistrian University of Athens)H-Index: 1
#2Theodore Sakelaropoulos (NYU: New York University)
Last.Vassilis G. GorgoulisH-Index: 47
view all 21 authors...
Abstract A major challenge in cancer treatment is predicting the clinical response to anti-cancer drugs on a personalized basis. The success of such a task largely depends on the ability to develop computational resources that integrate big “omic” data into effective drug-response models. Machine learning is both an expanding and an evolving computational field that holds promise to cover such needs. Here we provide a focused overview of: 1) the various supervised and unsupervised algorithms use...
1 CitationsSource
#1Katerina Harvati (University of Tübingen)H-Index: 34
#2Carolin Röding (University of Tübingen)H-Index: 1
Last.Mirsini Kouloukoussa (UoA: National and Kapodistrian University of Athens)H-Index: 8
view all 12 authors...
Two fossilized human crania (Apidima 1 and Apidima 2) from Apidima Cave, southern Greece, were discovered in the late 1970s but have remained enigmatic owing to their incomplete nature, taphonomic distortion and lack of archaeological context and chronology. Here we virtually reconstruct both crania, provide detailed comparative descriptions and analyses, and date them using U-series radiometric methods. Apidima 2 dates to more than 170 thousand years ago and has a Neanderthal-like morphological...
12 CitationsSource
#1Panagiota Economopoulou (UoA: National and Kapodistrian University of Athens)H-Index: 16
#2George Koutsodontis (UoA: National and Kapodistrian University of Athens)H-Index: 4
Last.Amanda Psyrri (UoA: National and Kapodistrian University of Athens)H-Index: 37
view all 14 authors...
Objectives Human papillomavirus-related oropharyngeal squamous cell carcinoma (HPV+ OPSCC) is increasing in incidence. Although HPV+ OPSCC has favorable prognosis, 10 to 25% of HPV+ OPSCCs eventually recur. We sought to evaluate the feasibility of detection of HPV16 E6/E7 expression in Circulating Tumor Cells (CTCs) and its utility as a prognostic tool in HPV16-associated OPSCC. Materials and methods We developed a highly sensitive RT-qPCR assay for HPV mRNA expression in EpCAM(+) CTCs. In 22 pa...
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#1Pavel N. Lobachevsky (University of Melbourne)H-Index: 15
#2Jessica Ventura (Royal Women's Hospital)H-Index: 3
Last.Olga A. Martin (University of Melbourne)H-Index: 21
view all 17 authors...
Purpose Nontargeted effects of ionizing radiation, by which unirradiated cells and tissues are also damaged, are a relatively new paradigm in radiobiology. We recently reported radiation-induced abscopal effects (RIAEs) in normal tissues; namely, DNA damage, apoptosis, and activation of the local and systemic immune responses in C57BL6/J mice after irradiation of a small region of the body. High-dose-rate, synchrotron-generated broad beam or multiplanar x-ray microbeam radiation therapy was used...
1 CitationsSource
#1Apostolos Pappas (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2Sophia Magkouta (UoA: National and Kapodistrian University of Athens)H-Index: 8
Last.Ioannis Kalomenidis (UoA: National and Kapodistrian University of Athens)H-Index: 18
view all 9 authors...
ABSTRACTVersican promotes experimental tumor growth through cell- and non cell-autonomous mechanisms. Its role in mesothelioma progression has not been investigated so far. In this study we investigated the impact of tumor-derived versican in mesothelioma progression and the underlying mechanism of its action. For this purpose, versican-silenced or control ΑE17 and ΑΒ1 murine mesothelioma cells were intrapleuraly injected into syngeneic mice, in order to create pleural mesotheliomas and pleural ...
4 CitationsSource
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