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Seminars in Cancer Biology
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#1Sundas Fayyaz (Rashid Latif Medical College)H-Index: 8
#2Zeeshan Javed (Rashid Latif Medical College)H-Index: 1
Last.Aamir Ahmad (USA: University of South Alabama)H-Index: 5
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Abstract Large-scale sequencing methodologies have helped us identify numerous genomic alterations and we have started to scratch the surface of many new targets for treatment of cancer and the associated predictive biomarkers. TRAIL (TNF-related apoptosis-inducing ligand) is a highly appreciated anti-cancer molecule because of its ability to selectively target cancer cells. However, confluence of information suggests that cancer cells develop resistance against TRAIL-based therapeutics. It is b...
#1Joana Balça-Silva (UC: University of Coimbra)H-Index: 7
#2Diana Matias (UFRJ: Federal University of Rio de Janeiro)H-Index: 8
Last.Vivaldo Moura-NetoH-Index: 20
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Abstract Glioblastoma (GB) is the more frequent and malignant brain tumour. In spite of all efforts, the median overall survival of GB patients remains approximately 15 months under therapy. The molecular biology underlying GB is complex, which highlight the need of specific treatment strategies. In fact, the deregulation of several molecular signalling pathways, the existence of the blood-brain barrier (BBB), that makes almost all the chemotherapeutic agents inaccessible to the tumour site, and...
#1Laurence Booth (VCU: Virginia Commonwealth University)H-Index: 16
#2Jane L. Roberts (VCU: Virginia Commonwealth University)H-Index: 14
Last.Paul Dent (VCU: Virginia Commonwealth University)H-Index: 81
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Abstract The molecular mechanisms by which tumor cells survive or die following therapeutic interventions are complex. There are three broadly defined categories of cell death processes: apoptosis (Type I), autophagic cell death (Type II), and necrosis (Type III). In hematopoietic tumor cells, the majority of toxic stimuli cause these cells to undergo a death process called apoptosis; apoptosis specifically involves the cleavage of DNA into large defined pieces and their subsequent localization ...
#1Michela PaselloH-Index: 14
#2Anna Maria Giudice (UNIBO: University of Bologna)
Last.Katia ScotlandiH-Index: 45
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Abstract Overexpression of ATP-binding cassette (ABC) transporters is a cause of drug resistance in a plethora of tumors. More recent evidence indicates additional contribution of these transporters to other processes, such as tumor cell dissemination and metastasis, thereby extending their possible roles in tumor progression. While the role of some ABC transporters, such as ABCB1, ABCC1 and ABCG2, in multidrug resistance is well documented, the mechanisms by which ABC transporters affect the pr...
#1Esther ArnaizH-Index: 2
#2Carla SoleH-Index: 4
Last.Charles H. Lawrie (Ikerbasque)H-Index: 28
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Abstract Circular RNAs (circRNAs) are a novel class of regulatory RNAs that despite being relatively abundant have only recently begun to be explored. There are many thousands of genes that appear capable of producing circRNAs, however the function of all but a handful remain to be determined. What is emerging about these highly conserved molecules is that they play important roles in biology and cancer biology in particular. The most explored function of circRNAs is as master regulators of gene...
#1Ammad Ahmad Farooqi (Brazilian Institute of Geography and Statistics)H-Index: 16
#2Mustafa B. A. Djamgoz (Cyprus International University)H-Index: 12
Last.Zahid H. Siddik (University of Texas MD Anderson Cancer Center)H-Index: 33
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Abstract Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on insights gleaned from almost a quarter century of research, it is obvious that deregulation of spatio-temporally controlled signaling pathways play instrumental role in development and progression of colorectal cancer. High-throughput technologies have helped to develop a sharper and broader understanding of the wide ranging signal transduction cascades which also contribute to development of drug...
#1Seyedeh Alia Moosavian (MUMS: Mashhad University of Medical Sciences)H-Index: 2
#2Vanessa Bianconi (University of Perugia)H-Index: 10
Last.Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 59
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Abstract Despite considerable advances in the application of liposomal drug delivery systems in cancer treatment, the clinical application of liposomal formulations has been limited by many factors. It seems that there is a wide gap between results of experimental studies and clinical application of liposomes. In this review, we discuss barriers which limit the translation of liposomal delivery systems in cancer therapy. The main focus of this review will be on differences between preclinical an...
#1Ammad Ahmad Farooqi (Rashid Latif Medical College)H-Index: 16
#2Enrique Fuentes-Mattei (University of Texas MD Anderson Cancer Center)H-Index: 13
Last.George A. Calin (University of Texas MD Anderson Cancer Center)H-Index: 108
view all 7 authors...
Abstract Epigenetic abnormalities and aberrant expression of non-coding RNAs are two emerging features of cancer cells, both of which are responsible for deregulated gene expression. In this review, we describe the interplay between the two. Specific themes include epigenetic silencing of tumor suppressor miRNAs, epigenetic activation of oncogenic miRNAs, epigenetic aberrations caused by miRNAs, and naturally occurring compounds which modulate miRNA expression through epigenetic mechanisms.
#1Verena Schildgen (MIT: Massachusetts Institute of Technology)H-Index: 14
#2Oliver Schildgen (MIT: Massachusetts Institute of Technology)H-Index: 25
Abstract Driver mutations are considered to be responsible for the majority of cancers and several of those mutations provide targets in order to set up personalized therapies. So far the generally accepted opinion had been that driver mutations occur as stand-alone factors, but novel sequencing technologies induced an essential rethink. Next generation sequencing approaches have shown that double, triple or multiple concurrent mutations could occur within the same tumour and may by interaction ...
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