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Seminars in Cancer Biology
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9.66
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1930
Papers 1936
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#1Charbel Moussalem (AUB: American University of Beirut)H-Index: 2
#2Elie Massaad (AUB: American University of Beirut)H-Index: 3
Last. Ibrahim Omeis (AUB: American University of Beirut)H-Index: 2
view all 8 authors...
Abstract Sarcomas, especially spine sarcomas, are rare yet debilitating and are underestimated types of cancer. Treatment options for spine sarcomas are limited to chemotherapy, radiotherapy and surgical intervention. Accumulating evidence suggests a complex course associated with the treatment of spine sarcomas as compared to other soft tissue sarcomas in the extremities since adjuvant therapy adds limited success to the oncological outcome. Likewise, the limitations of surgical interventions i...
1 CitationsSource
#1Silvia Martina Ferrari (UniPi: University of Pisa)H-Index: 30
#1Silvia Ferrari (UniPi: University of Pisa)H-Index: 27
Last. Alessandro Antonelli (UniPi: University of Pisa)H-Index: 52
view all 7 authors...
Abstract In the last decades, many studies conducted in vitro, and in vivo, have shown that thyroid autoimmunity and thyroid cancer (TC) (mainly papillary TC) can be concomitant, even if the exact mechanisms at the basis of this association are still not clear. Growing incidence of TC coincides with increased registration of autoimmune thyroid disorders (AITD) suggesting an association between those pathologies. Elevated TSH levels and thyroid autoimmunity were defined as independent risk factor...
9 CitationsSource
#1Galina Gabriely (Brigham and Women's Hospital)H-Index: 17
#2Francisco J. Quintana (Broad Institute)H-Index: 58
Abstract Glioblastoma (GBM) is an aggressive and incurable brain tumor; its malignancy has been associated with the activity of tumor infiltrating myeloid cells. Myeloid cells play important roles in the tumor control by the immune response, but also in tumor progression. Indeed, GBM exploits multiple mechanisms to recruit and modulate myeloid cells. The Aryl Hydrocarbon Receptor (AHR) is a ligand activated transcription factor implicated in the regulation of myeloid cells. In this review, we wi...
4 CitationsSource
#1Kari Hemminki (DKFZ: German Cancer Research Center)H-Index: 92
#2Wuqing Huang (Lund University)H-Index: 2
Last. Jianguang Ji (Hebei Medical University)H-Index: 30
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Abstract Autoimmune diseases are characterized by the irregular functioning of the immune system that leads to the loss of tolerance to self-antigens. The underlying nature of autoimmune diseases has led to speculation that the risk of malignancy might be higher or lower in patients with such diseases. However, the rarity and heterogeneity of both autoimmune diseases and malignancies is the main challenge for systematic exploration of associations between autoimmune diseases and cancer. The nati...
3 CitationsSource
Abstract Cancer and autoimmune disease are closely related, and many therapeutic antibodies are widely used in clinics for the treatment of both diseases. Among them, the anti-CD20 antibody has proven to be effective against both lymphoid malignancy and autoimmune disease. Moreover, immune checkpoint blockade using the anti-PD1/PD-L1/CTLA4 antibody has improved the prognosis of patients with refractory solid tumors. At the same time, however, over-enhancement of immunoreaction can induce autoimm...
6 CitationsSource
#1Ilaria Muller (Cardiff University)H-Index: 8
#2Peter Barrett-Lee (Cardiff University)H-Index: 33
Abstract The association between breast cancer and benign thyroid disorders, in particular thyroid autoimmunity, has been debated for decades. Autoantibodies to thyroid peroxidase, the hallmark of thyroid autoimmunity, have a higher prevalence among patients with breast cancer compared with the general population. Furthermore a correlation between their positivity and a better prognosis of breast cancer was found in several independent small-scale studies, even if such observation was not confir...
3 CitationsSource
#1Prabhakaran Kumar (UIC: University of Illinois at Chicago)H-Index: 8
#2Shikha Saini (UIC: University of Illinois at Chicago)H-Index: 12
Last. Bellur S. Prabhakar (UIC: University of Illinois at Chicago)H-Index: 47
view all 3 authors...
Abstract Regulatory T-cells (Tregs) can facilitate immune evasion by tumor cells by dampening anti-tumor immunity. Reduced Teff/Treg ratio and enhanced Treg functional activity have been observed in patients suffering from different types of cancers, and attenuated Treg numbers/functions can serve as prognostic indicators. Normally, Tregs play an essential role in the maintenance of immune tolerance and prevention of autoimmunity. The most common immune checkpoint blockers (ICB) targeting co-inh...
12 CitationsSource
#1Shams Tabrez (KAU: King Abdulaziz University)H-Index: 25
#2Nasimudeen R. Jabir (PRIST University)H-Index: 1
Last. Mohammad A. Kamal (KAU: King Abdulaziz University)H-Index: 32
view all 9 authors...
Abstract Cancer and autoimmune diseases are the two devastating conditions that together constitute a leading health problem worldwide. The rising burden of these disorders in the developing world demands a multifaceted approach to address the challenges it poses. Understanding the root causes and specific molecular mechanisms by which the progression of the diseases takes place is need of the hour. A strong inflammatory background and common developmental pathways, such as activation of immune ...
1 CitationsSource
#1Changchun Xiao (Ha Tai: Xiamen University)H-Index: 24
#2David Nemazee (Scripps Research Institute)H-Index: 59
Last. Alicia Gonzalez-Martin (CSIC: Spanish National Research Council)H-Index: 12
view all 3 authors...
Since the discovery of the first microRNA (miRNA) in 1993, thousands of miRNAs have been identified in humans and mice and many of them have been shown to control a large variety of cellular processes in different cell types including those composing the immune system. MicroRNAs regulate virtually all aspects of immune cell development, differentiation and function. Studies have shown that these molecules are involved in the maintenance of lymphocyte tolerance and, when dysregulated, promote the...
1 CitationsSource
#1M. Akhtar Anwar (AUB: American University of Beirut)H-Index: 5
#2Chirine El-Baba (AUB: American University of Beirut)H-Index: 2
Last. Ali H. Eid (Qatar University)H-Index: 21
view all 13 authors...
Abstract At the dawn of the third millennium, cancer has become the bane of twenty-first century man, and remains a predominant public health burden, affecting welfare and life expectancy globally. Spinal osteogenic sarcoma, a primary spinal malignant tumor, is a rare and challenging neoplastic disease to treat. After the conventional therapeutic modalities of chemotherapy, radiation and surgery have been exhausted, there is currently no available alternative therapy in managing cases of spinal ...
2 CitationsSource
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