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Effect of the volume and intensity of exercise training on insulin sensitivity

Published on Jan 1, 2004in Journal of Applied Physiology3.14
· DOI :10.1152/japplphysiol.00707.2003
Joseph A. Houmard58
Estimated H-index: 58
,
Charles J. Tanner27
Estimated H-index: 27
+ 3 AuthorsWilliam E. Kraus79
Estimated H-index: 79
Abstract
Physical activity enhances insulin action in obese/overweight individuals. However, the exercise prescription required for the optimal enhancement is not known. The purpose of this study was to test the hypothesis that exercise training consisting of vigorous-intensity activity would enhance insulin sensitivity more substantially than moderate-intensity activity. Sedentary, overweight/obese subjects (n = 154) were randomly assigned to either control or an exercise group for 6 mo: 1) low-volume/moderate-intensity group [∼12 miles walking/wk at 40–55% peak O2 consumption (Vo2 peak)], 2) low-volume/high-intensity group (∼12 miles jogging/wk at 65–80% Vo2 peak), and 3) high-volume/high-intensity group (∼20 miles jogging/wk at 65–80% Vo2 peak). Training volume (miles/wk) was achieved by exercising ∼115 min/wk (low-volume/high-intensity group) or ∼170 min/wk (low-volume/moderate-intensity and high-volume/high-intensity groups). Insulin action was measured with an insulin sensitivity index (SI) from an intrav...
  • References (27)
  • Citations (401)
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References27
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#1Mihaela Tanasescu (Harvard University)H-Index: 5
Last. Frank B. HuH-Index: 205
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MULTIPLE EPIDEMIOLOGIC studies have shown an inverse relationship between physical activity andriskof coronaryheartdisease (CHD). Sedentary individuals have almost twice the risk of CHD as those performing high-intensity exercise. However, the optimal level of exercise for preventing CHD is unclear. In some studies, the reduction in risk from increased levels of activity appeared to be linear up to a certain level above which there was no further benefit; in others, the effect was restricted to ...
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Prolonged adaptation to fat-rich diet and training; effects on body fat stores and insulin resistance in man
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Insulin resistance of skeletal muscle glucose transport is a key defect in the development of impaired glucose tolerance and Type 2 diabetes. It is well established that both an acute bout of exercise and chronic endurance exercise training can have beneficial effects on insulin action in insulin-resistant states. This review summarizes the present state of knowledge regarding these effects in the obese Zucker rat, a widely used rodent model of obesity-associated insulin resistance, and in insul...
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KRAUS, W. E., C. E. TORGAN, B. D. DUSCHA, J. NORRIS, S. A. BROWN, F. R. COBB, C. W. BALES, B. H. ANNEX, G. P. SAMSA, J. A. HOUMARD, and C. A. SLENTZ. Studies of a targeted risk reduction intervention through defined exercise (STRRIDE). Med. Sci. Sports Exerc., Vol. 33, No. 10, 2001, pp. 1774–1784. P
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#2Ralph B. D'Agostino (Wake Forest University)H-Index: 197
Last. Richard N. Bergman (SC: University of Southern California)H-Index: 96
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Context.—Exercise training is associated with improved insulin sensitivity (SI), but the potential impact of habitual, nonvigorous activity is uncertain.Objective.—To determine whether habitual, nonvigorous physical activity, as well as vigorous and overall activity, is associated with better SI.Design.—A multicultural epidemiologic study.Setting.—The Insulin Resistance Atherosclerosis Study, conducted in Oakland, Calif; Los Angeles, Calif; the San Luis Valley, Colo; and San Antonio, Tex.Partici...
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Physical exercise can be an important adjunct in the treatment of both non–insulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus. Over the past several years, considerable progress has been made in understanding the molecular basis for these clinically important effects of physical exercise. Similarly to insulin, a single bout of exercise increases the rate of glucose uptake into the contracting skeletal muscles, a process that is regulated by the translocation of GLUT4 glu...
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#1Jie KangH-Index: 39
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