William E. Kraus
Duke University
Publications 658
#1Tiew-Hwa Katherine Teng (UWA: University of Western Australia)H-Index: 15
#2Lauren B. Cooper (Duke University)H-Index: 10
Last.Carolyn S.P. LamH-Index: 46
view all 14 authors...
#1James A. Timmons ('KCL': King's College London)H-Index: 41
#2Iain J. Gallagher (University of Stirling)H-Index: 18
Last.Philip J. Atherton (University of Nottingham)H-Index: 43
view all 8 authors...
Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below.
#1Beverly H. Brummett (Duke University)H-Index: 35
#2Michael A. Babyak (Duke University)H-Index: 51
Last.Redford B. Williams (Duke University)H-Index: 65
view all 9 authors...
Abstract The present study used harmonized data from eight studies (N = 28,891) to examine the association between socioeconomic status (SES) and resting systolic blood pressure (SBP). The study replicates and extends our prior work on this topic by examining potential moderation of this association by race and gender. We also examined the extent to which body mass index (BMI), waist circumference (WC), and smoking might explain the association between SES and SBP. Data were available from six r...
#1Jessica A. Regan (Duke University)H-Index: 8
#2Dalane W. Kitzman (Wake Forest University)H-Index: 80
Last.Robert J. Mentz (Duke University)H-Index: 34
view all 11 authors...
Abstract Objectives This study sought to determine whether age modifies the impact of key comorbidities on clinical outcomes for patients with heart failure with reduced ejection fraction (HFrEF). Background Comorbidities impact outcomes in HFrEF. However, the effect of age on the impact of comorbidities on prognosis is not clearly understood. Methods Cox proportional hazards models were used assessed interactions between age and comorbidities on the primary composite endpoint (all-cause mortali...
1 CitationsSource
#1James A. Blumenthal (Duke University)H-Index: 95
#2Patrick Smith (Duke University)H-Index: 38
Last.Andrew Sherwood (Duke University)H-Index: 55
view all 11 authors...
#1Leanna M. Ross (Duke University)H-Index: 1
#2Cris A. Slentz (Duke University)H-Index: 36
Last.William E. Kraus (Duke University)H-Index: 79
view all 3 authors...
Background: Understanding group responses to a given exercise exposure is becoming better developed; however, understanding of individual responses to specific exercise exposures is significantly underdeveloped and must advance before personalized exercise medicine can become a functional reality. Herein, utilizing data from the STRRIDE studies, we address some of the key issues surrounding our efforts to develop better understanding of individual exercise responsiveness. Methods: We assessed in...
#1Jawan W Abdulrahim (Duke University)
#2Lydia Coulter Kwee (Duke University)H-Index: 8
Last.Svati H. Shah (Duke University)H-Index: 49
view all 9 authors...
Background DNA methylation is implicated in many chronic diseases and may contribute to mortality. Therefore, we conducted an epigenome‐wide association study (EWAS) for all‐cause mortality with wh...
#1Terry E. Jones (ECU: East Carolina University)H-Index: 14
#2J PoriesWalter (ECU: East Carolina University)H-Index: 59
Last.G. Lynis Dohm (ECU: East Carolina University)H-Index: 42
view all 10 authors...
Abstract Background Fasting lactate is elevated in metabolic diseases and could possibly be predictive of the risk of developing the metabolic syndrome. Methods Plasma samples were analyzed for fasting lactate to compare lean subjects, nondiabetic subjects with severe obesity, and metabolically impaired subjects. Subjects with severe obesity were studied 1 week before and 1 week to 9 months after gastric bypass surgery. Subjects with components of the metabolic syndrome were studied before and a...
#1Ambarish Pandey (UTSW: University of Texas Southwestern Medical Center)H-Index: 29
#2William E. Kraus (Duke University)H-Index: 79
Last.Dalane W. Kitzman (Wake Forest University)H-Index: 80
view all 4 authors...
Abstract Objectives The aim of this study was to evaluate the association between age and invasive cardiovascular hemodynamics during upright exercise among healthy adults. Background The marked age-related decline in maximal exercise oxygen uptake (peak VO2) may contribute to the high burden of heart failure among older individuals and their greater severity of exertional symptoms. However, the mechanisms underlying this decline are not well understood. Methods A total of 104 healthy community-...
#1Jin Zhou (NUS: National University of Singapore)H-Index: 12
#2Daniel Parker (Duke University)H-Index: 6
Last.William E. Kraus (Duke University)H-Index: 79
view all 8 authors...
ABSTRACT Although both exercise and thyroid hormone (TH) status can cause cellular and metabolic changes in skeletal muscle, the impact of TH status on exercise-associated changes is not well understood. Here, we examined the effects of TH status on muscle fiber type, cell signaling, and metabolism in a rabbit model of exercise training — chronic motor nerve stimulation (CMNS). Five rabbits were rendered hypothyroid for seven to eight weeks and three rabbits were made hyperthyroid for two weeks ...