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Joseph A. Houmard
East Carolina University
EndocrinologyInsulinSkeletal muscleDiabetes mellitusMedicine
272Publications
58H-index
12.8kCitations
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Publications 280
Newest
#1Nicholas T Broskey (ECU: East Carolina University)
#2Kai Zou (University of Massachusetts Boston)H-Index: 10
Last. Joseph A. Houmard (ECU: East Carolina University)H-Index: 58
view all 4 authors...
Blood lactate concentrations have traditionally been utilized as an index of exercise intensity or clinical hyperlactatemia. However, more recent data suggests that fasting plasma lactate can also be indicative of the risk for subsequent metabolic disease. The hypothesis presented is that fasting blood lactate accumulation reflects impaired mitochondrial substrate utilization, which in turn influences metabolic disease risk.
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#1Damon L. Swift (ECU: East Carolina University)H-Index: 18
#2Joshua E. McGee (ECU: East Carolina University)H-Index: 2
Last. Joseph A. Houmard (ECU: East Carolina University)H-Index: 58
view all 12 authors...
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#1Leanna M. Ross (Duke University)H-Index: 1
#2Cris A. Slentz (Duke University)H-Index: 36
Last. William E. Kraus (Duke University)H-Index: 79
view all 8 authors...
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#1Benjamin A. Kugler (University of Massachusetts Boston)
#2Anders E. Gundersen (University of Massachusetts Boston)
Last. Kai Zou (University of Massachusetts Boston)H-Index: 10
view all 8 authors...
Impaired insulin-mediated glucose partitioning is an intrinsic metabolic defect in skeletal muscle from severely obese humans (BMI ≥ 40 kg/m2). Roux-en-Y gastric bypass (RYGB) surgery has been shown to improve glucose metabolism in severely obese humans. The purpose of the study was to determine the effects of RYGB surgery on glucose partitioning, mitochondrial network morphology, and the markers of mitochondrial dynamics skeletal muscle from severely obese humans. Human skeletal muscle cells we...
1 CitationsSource
#1Anders E. Gundersen (University of Massachusetts Boston)
#2Benjamin A. Kugler (University of Massachusetts Boston)
Last. Kai Zou (University of Massachusetts Boston)H-Index: 10
view all 6 authors...
Healthy mitochondrial networks are maintained via balanced integration of mitochondrial quality control processes (biogenesis, fusion, fission and mitophagy). The purpose of the study was to invest...
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#1Patrick J. Ferrara (UofU: University of Utah)H-Index: 2
#1Patrick J. Ferrara (UofU: University of Utah)H-Index: 2
Last. Katsuhiko FunaiH-Index: 16
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Aberrant lipid metabolism promotes the development of skeletal muscle insulin resistance, but the exact identity of lipid-mediated mechanisms relevant to human obesity remains unclear. A comprehensive lipidomic analyses of primary myocytes from lean insulin-sensitive (LN) and obese insulin-resistant (OB) individuals revealed several species of lysophospholipids (lyso-PL) that were differentially-abundant. These changes coincided with greater expression of lysophosphatidylcholine acyltransferase ...
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#1Joseph A. Houmard (ECU: East Carolina University)H-Index: 58
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#1Joseph A. Houmard (ECU: East Carolina University)H-Index: 58
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#1Joseph A. Houmard (ECU: East Carolina University)H-Index: 58
#2Alec Chaves (ECU: East Carolina University)H-Index: 1
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#1Joshua E. McGee (ECU: East Carolina University)H-Index: 2
#2Savanna G. Barefoot (ECU: East Carolina University)
Last. Damon L. Swift (ECU: East Carolina University)H-Index: 18
view all 11 authors...
African Americans have a disproportionate prevalence and incidence of type 2 diabetes compared with Caucasians. Recent evidence indicates that low cardiorespiratory fitness (CRF) level, an independent risk factor for type 2 diabetes, is also more prevalent in African Americans than Caucasians. Numerous studies in Caucasian populations suggest that vigorous exercise intensity may promote greater improvements in CRF and other type 2 diabetes risk factors (e.g., reduction of glucose/insulin levels,...
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