GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine
Abstract
The present study evaluates immunogenicity and protection potency of a codon-optimized GRA1 DNA vaccine, wild type GRA1 DNA vaccine and an adjuvanted recombinant GRA1 protein vaccine candidate in BALB/c mice against lethal toxoplasmosis. Of the three GRA1 vaccines tested, the recombinant GRA1 protein vaccine results reveal significant increase in immune response and prolonged survival against acute toxoplasmosis compared to DNA vaccinations....
Paper Details
Title
GRA1 protein vaccine confers better immune response compared to codon-optimized GRA1 DNA vaccine
Published Date
Feb 1, 2007
Journal
Volume
25
Issue
10
Pages
1824 - 1837
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