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Frances Jurnak
University of California, Irvine
70Publications
25H-index
2,424Citations
Publications 70
Newest
#1Kimberley D. Lakes (UCI: University of California, Irvine)H-Index: 14
#2Shesha MarvinH-Index: 1
Last.Frances Jurnak (UCI: University of California, Irvine)H-Index: 25
view all 8 authors...
Abstract Objective To study dancers' perceptions of the physical, cognitive, affective, and social benefits of partnered dancing. Method 225 dancers (71% female) were recruited through a community ballroom dance center and completed an online survey designed to measure their perceptions of the physical, cognitive, affective, and social benefits of modern, partnered dance styles (swing, Lindy Hop, and ballroom dancing). Subgroups were formed for analyses. For one set of analyses, groups based on ...
#1Mert DöşkayaH-Index: 9
#2Ayşe CanerH-Index: 8
Last.Yüksel GürüzH-Index: 9
view all 5 authors...
The successful folding of a recombinant protein after expression and purification is essential for structural, biochemical and vaccination studies. Toxoplasma gondii recombinant GRA1 protein is a promising vaccine candidate against toxoplasmosis. In the present study, the folding of recombinant GRA1 protein has been evaluated by web based bioinformatics tools that predict protein folding. Subsequently, trypsin digestion, which is a simple indication of proper protein folding, has been used to de...
#1Yaxiong Tang (UCI: University of California, Irvine)H-Index: 8
#2Anne R. Simoneau (UCI: University of California, Irvine)H-Index: 22
Last.Frances Jurnak (UCI: University of California, Irvine)H-Index: 25
view all 13 authors...
Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation is associated with tobacco smoking and with invasive bladder cancer. The secreted Wnt inhibitory factor-1 (WIF1) has shown consistent growth-inhibitory effect on various cancer cell lines. Therefore, we assessed the mechanisms of action of WIF1 by either restoring WIF1 expression in invasive bladder cancer cell lines (T24 and TSU-PR1) or using a recombinant protein containing functional WIF1 domain. Both ec...
#1X. Joann You (UCI: University of California, Irvine)H-Index: 1
#2Peter J. BryantH-Index: 49
Last.Randall F. HolcombeH-Index: 23
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. Mutations in apc which lead to activation of the Wnt signaling pathway are a hallmark of sporadic colon cancers but occur infrequently in colon cancers arising in patients with inflammatory bowel disease (IBD). There is evidence, however, that other components of the Wnt pathway may be altered in IBD-related colon cancer. In this study, we examined the expression the Wnt pathway components frizzled (Fz), the cell surface receptor, and disheveled (DVL), a family of cytoplasmic signal transducti...
#1Yaxiong Tang (UCI: University of California, Irvine)H-Index: 8
#2Anne R. Simoneau (UCI: University of California, Irvine)H-Index: 22
Last.Xiaolin Zi (UCI: University of California, Irvine)H-Index: 29
view all 10 authors...
4377 Recent studies have demonstrated that down-regulation of secreted Wnt antagonists, including Wnt inhibitory factor-1 (WIF-1), through promoter hypermethylation is associated with invasive stage bladder cancer. To examine the biological effect of the secreted Wnt antagonist WIF-1 on bladder cancer cells, we have produced a recombinant protein containing the functional WIF-1 domain (WD) from E.coli . Using L-cells, we showed that the recombinant WD protein inhibited Wnt-1 induced stabilizatio...
#1Mert Döşkaya (Ege University)H-Index: 9
Last.Jessica R. SchulzH-Index: 1
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The present study evaluates immunogenicity and protection potency of a codon-optimized GRA1 DNA vaccine, wild type GRA1 DNA vaccine and an adjuvanted recombinant GRA1 protein vaccine candidate in BALB/c mice against lethal toxoplasmosis. Of the three GRA1 vaccines tested, the recombinant GRA1 protein vaccine results reveal significant increase in immune response and prolonged survival against acute toxoplasmosis compared to DNA vaccinations. Immune response and protection conferred by codon-opti...
#1Susan E. Heffron (UCI: University of California, Irvine)H-Index: 7
#2Suet Mui (UCI: University of California, Irvine)H-Index: 1
Last.Frances Jurnak (UCI: University of California, Irvine)H-Index: 25
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Two crystal forms of a complex between trypsin-modified elongation factor Tu–MgGDP from Escherichia coli and the antibiotic tetracycline have been solved by X-ray diffraction analysis to resolutions of 2.8 and 2.1 A, respectively. In the P21 form, cocrystals were grown from a solution mixture of the protein and tetracycline. Six copies of the trypsin-modified EF-Tu–MgGDP–tetracycline complex are arranged as three sets of dimers in the asymmetric unit. In the second crystal form, tetracycline was...
#1Susan E. Heffron (UCI: University of California, Irvine)H-Index: 7
#2Rhonda MoellerH-Index: 3
Last.Frances Jurnak (UCI: University of California, Irvine)H-Index: 25
view all 3 authors...
Escherichia coli elongation factor Tu–GDP (EF-Tu–GDP) was crystallized in the presence of novel inhibitors. The only crystals which could be grown were epitaxially as well as merohedrally twinned, highly mosaic and diffracted to a resolution of 3.4 A in space group P3121, with unit-cell parameters a = b = 69.55, c = 169.44 A, α = β = 90, γ = 120°. To determine whether an inhibitor was present in the crystal, a poor-quality X-ray diffraction data set had to be processed. The three-dimensional str...
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