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#1Christina E. HoeveH-Index: 1
#1Christina E. Hoeve (EUR: Erasmus University Rotterdam)
Last. Sabine M. J. M. StrausH-Index: 25
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Abstract Background Serious adverse reactions after immunization are rare but do occur. In very rare instances, cases with fatal outcome have been reported. These reports can have a huge impact and even more so when due to an immunization error. The aim of this study is to systematically review immunization errors with fatal outcomes in EudraVigilance. Methods This was a case-series analysis of Individual Case Safety Reports (ICSRs) reporting immunization errors and a fatal outcome. To determine...
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#1Robert I. Menzies (UNSW: University of New South Wales)H-Index: 20
Last. Helen MarshallH-Index: 29
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Abstract Background The effectiveness of SMS reminders in improving vaccination coverage has been assessed previously, with effectiveness varying between settings. However, there are very few studies on their effect on the timeliness of vaccination. Design Unblinded, randomised controlled trial with blocked sampling. Methods 1594 Australian infants and young children were recruited to assess the impact of (1) SMS reminders only, (2) a personalised calendar, (3) SMS reminder and personalised cale...
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#1Mayumi Tachibana (Ehime University)H-Index: 16
#2Minami Baba (Ehime University)H-Index: 3
Last. Tomoko Ishino (Ehime University)H-Index: 15
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Abstract Malaria transmission-blocking vaccines (TBVs) aim to inhibit parasite fertilization or further development within the mosquito midgut. Because TBV-immunized individuals reduce the transmission of malaria parasites to mosquito vectors, TBVs could serve as a promising strategy to eliminate malaria. We previously reported that a male specific protein, PyMiGS (Plasmodium yoelii microgamete surface protein), is localized to the surface of microgametes and anti-PyMiGS antibodies have strong t...
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#1Rowena Silcock (Royal Children's Hospital)
#2Nigel W. Crawford (Royal Children's Hospital)H-Index: 17
Last. Kirsten P. Perrett (University of Melbourne)H-Index: 13
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Abstract Background Subcutaneous nodules are a rare adverse event following immunization (AEFI). We aimed to describe nodules at the injection site reported to SAEFVIC (Surveillance of Adverse Events Following Vaccination in the Community) using the Brighton Collaboration Case Definition (BCCD), management and recurrence following subsequent immunizations. Method We assessed 58 cases ( Results 71% (41/58 reported cases) were consistent with the BCCD for subcutaneous nodule, 14% (8 cases) were ‘p...
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#1Edward A. Belongia (Marshfield Clinic)H-Index: 38
#2Min Z. Levine (CDC: Centers for Disease Control and Prevention)H-Index: 14
Last. Huong Q. McLean (Marshfield Clinic)H-Index: 21
view all 7 authors...
Abstract Background Licensed inactivated influenza vaccines (IIV) are recommended for persons aged ≥65 years, including trivalent high-dose IIV (HD-IIV3) and adjuvanted IIV (aIIV3); both are manufactured in eggs. Quadrivalent recombinant vaccine (RIV4) is produced without eggs. We conducted an exploratory study to compare immunogenicity of HD-IIV3, aIIV3 and RIV4 against cell-grown vaccine and circulating A(H3N2) viruses in 2017–18. Methods Eighty-nine adults aged 65–74 years participating in a ...
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Last. Caroline L. TrotterH-Index: 42
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Abstract Objective To estimate neonatal health benefits and healthcare provider costs of a theoretical Group B streptococcal (GBS) hexavalent maternal vaccination programme in The Gambia, a low-income setting in West Africa. Methods A static decision analytic cost-effectiveness model was developed from the healthcare provider perspective. Demographic data and acute care costs were available from studies in The Gambia undertaken in 2012–2015. Further model parameters were taken from United Nation...
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#2Jiexiong XieH-Index: 10
Last. Maria B. BarrioH-Index: 4
view all 13 authors...
Abstract Vaccination is the main tool for controlling infectious diseases in livestock. Yet current vaccines only provide partial protection raising concerns about vaccine effectiveness in the field. Two successive transmission trials were performed involving 52 pigs to evaluate the effectiveness of a Porcine Reproductive and Respiratory Syndrome (PRRS) vaccinal strain candidate against horizontal transmission of a virulent heterologous strain. PRRS virus, above the specified limit of detection,...
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#1Dylan M. Johnson (University of Louisville)H-Index: 1
#2Jenny D. Jokinen (University of Louisville)H-Index: 4
Last. Igor S. Lukashevich (University of Louisville)H-Index: 24
view all 9 authors...
Abstract Junin (JUNV) and Machupo (MACV), two mammalian arenaviruses placed on the 2018 WHO watch list, are prevalent in South America causing Argentine and Bolivian hemorrhagic fevers (AHF and BHF), respectively. The live attenuated JUNV vaccine, Candid #1, significantly reduced the incidence of AHF. Vaccination induces neutralizing antibody (nAb) responses which effectively target GP1 (the viral attachment glycoprotein) pocket which accepts the tyrosine residue of the cellular receptor, human ...
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#2Yanli YangH-Index: 6
Last. Songping ZhangH-Index: 22
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Abstract Adjuvants are important to enhance the antigens immunogenicity, but may also alter the structures of antigens. Currently off-line methods for adjuvants induced antigen alteration suffer from incomplete release and possible structural alteration of antigens. Here we investigated the differential scanning fluorimetry (DSF) as an in-situ and high-throughput strategy to analyze the stability of inactivated foot-and-mouth disease virus (iFMDV), known as 146S, in three representative adjuvant...
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#1Steffen MuellerH-Index: 25
#2Charles B. StauftH-Index: 3
Last. J. Robert ColemanH-Index: 7
view all 7 authors...
Abstract Despite a critical need for a respiratory syncytial virus (RSV) vaccine and decades of development efforts, a vaccine to protect infants, elderly, and other at-risk populations from RSV infection remains elusive. We have previously generated a new, live-attenuated vaccine candidate against RSV using rational, computer-aided gene design and chemical synthesis through a process termed viral gene “deoptimization.” In this study, we assessed the attenuation, immunogenicity, and efficacy of ...
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