Original paper
The Effect of MAPT H1 and APOE ε4 on Transition from Mild Cognitive Impairment to Dementia
Abstract
Microtubule-associated protein tau (MAPT) and apolipoprotein E (APOE) are involved in the pathogenic mechanisms of Alzheimer's disease (AD). We prospectively followed three longitudinal independent samples (total n=319) with amnestic mild cognitive impairment (MCI) and analyzed whether MAPT H1/H2 haplotypes and APOE ε4 polymorphisms accelerated the rate of progression from MCI to dementia. At the end of the study, 172 subjects remained...
Paper Details
Title
The Effect of MAPT H1 and APOE ε4 on Transition from Mild Cognitive Impairment to Dementia
Published Date
Jan 7, 2011
Volume
22
Issue
4
Pages
1065 - 1071
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Notes
History