Impairment and distress patterns distinguishing the melancholic depression subtype: An iSPOT-D report

This study seeks to provide a comprehensive and systematic evaluation of baseline clinical and psychological features and treatment response characteristics that differentiate Major Depressive Disorder (MDD) outpatients with and without melancholic features. Reflecting the emphasis in DSM-5, we also include impairment and distress. Participants were assessed pre-treatment on clinical features (severity, risk factors, comorbid conditions, illness...