Cloning of a T-type Ca2+ channel isoform in insulin-secreting cells.
Abstract
The T-type Ca2+ channel is an important determinant of electrical activity and of Ca2+ influx in rat and human pancreatic beta-cells. We have identified and sequenced a cDNA encoding a T-type Ca2+ channel alpha1-subunit derived from INS-1, the rat insulin-secreting cell line. The sequence of the cDNA indicates a protein composed of 2,288 amino acids that shares 96.3% identity to alpha1G, the neuronal T-type Ca2+ channel subunit. The...
Paper Details
Title
Cloning of a T-type Ca2+ channel isoform in insulin-secreting cells.
Published Date
Jan 1, 2000
Journal
Volume
49
Issue
1
Pages
59 - 64
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