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Arin Bhattacharjee
State University of New York System
41Publications
22H-index
1,687Citations
Publications 41
Newest
#1Kerri D. Pryce (SUNY: State University of New York System)H-Index: 2
#2Rasheen Powell (SUNY: State University of New York System)
Last.Arin Bhattacharjee (SUNY: State University of New York System)H-Index: 22
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Voltage-dependent sodium (NaV) 1.8 channels regulate action potential generation in nociceptive neurons, identifying them as putative analgesic targets. Here, we show that NaV1.8 channel plasma mem...
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#1Sushmitha GururajH-Index: 2
#2Katherine M. Evely (SUNY: State University of New York System)H-Index: 2
Last.Arin Bhattacharjee (SUNY: State University of New York System)H-Index: 22
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Abstract The sodium-activated potassium (KNa) channel Kcnt1 (Slack) is abundantly expressed in nociceptor (pain sending) neurons of the dorsal root ganglion (DRG), where they transmit the large outward conductance IKNa and arbitrate membrane excitability. Slack channel expression at the DRG membrane is necessary for their characteristic firing accommodation during maintained stimulation, and reduced membrane channel density causes hyperexcitability. We have previously shown that in a pro-inflamm...
2 CitationsSource
#1Sushmitha Gururaj (SUNY: State University of New York System)H-Index: 2
#2Elizabeth E. Palmer (UNSW: University of New South Wales)H-Index: 11
Last.Arin Bhattacharjee (SUNY: State University of New York System)H-Index: 22
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Summary Early infantile epileptic encephalopathies (EOEE) are a debilitating spectrum of disorders associated with cognitive impairments. We present a clinical report of a KCNT2 mutation in an EOEE patient. The de novo heterozygous variant Phe240Leu SLICK was identified by exome sequencing and confirmed by Sanger sequencing. Phe240Leu rSlick and hSLICK channels were electrophysiologically, heterologously characterized to reveal three significant alterations to channel function. First, [Cl − ] i ...
7 CitationsSource
#1Katherine M. Evely (UB: University at Buffalo)H-Index: 1
#2Kerri D. Pryce (UB: University at Buffalo)H-Index: 1
Last.Arin Bhattacharjee (UB: University at Buffalo)H-Index: 22
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Sodium-activated potassium (KNa) channels contribute to firing frequency adaptation and slow after hyperpolarization. The KCNT1 gene (also known as SLACK) encodes a KNa subunit that is expressed throughout the central and peripheral nervous systems. Missense mutations of the SLACK C-terminus have been reported in several patients with rare forms of early onset epilepsy and in some cases severely delayed myelination. To date, such mutations identified in patients with autosomal dominant nocturnal...
5 CitationsSource
#1Katherine M. EvelyH-Index: 2
#2Kerri D. PryceH-Index: 2
Last.Arin BhattacharjeeH-Index: 22
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The sodium-activated potassium channel Slack (Kcnt1, Slo2.2) is highly expressed in dorsal root ganglion neurons where it regulates neuronal firing. Several studies have implicated the Slack channel in pain processing, but the precise mechanism or the levels within the sensory pathway where channels are involved remain unclear. Here, we furthered the behavioral characterization of Slack channel knockout mice and for the first time examined the role of Slack channels in the superficial, pain-proc...
3 CitationsSource
#1Danielle L. Tomasello (SUNY: State University of New York System)H-Index: 1
#2Edward Hurley (SUNY: State University of New York System)H-Index: 2
Last.Arin Bhattacharjee (SUNY: State University of New York System)H-Index: 22
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The Slick (Kcnt2) sodium-activated potassium (KNa) channel is a rapidly gating and weakly voltage-dependent and sodium-dependent potassium channel with no clearly defined physiological function. Within the dorsal root ganglia (DRGs), we show Slick channels are exclusively expressed in small-sized and medium-sized calcitonin gene–related peptide (CGRP)-containing DRG neurons, and a pool of channels are localized to large dense-core vesicles (LDCV)-containing CGRP. We stimulated DRG neurons for CG...
2 CitationsSource
#1Sushmitha Gururaj (SUNY: State University of New York System)H-Index: 2
#2John Fleites (SUNY: State University of New York System)H-Index: 1
Last.Arin Bhattacharjee (SUNY: State University of New York System)H-Index: 22
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p38 MAPK has long been understood as an inducible kinase under conditions of cellular stress, but there is now increasing evidence to support its role in the regulation of neuronal function. Several phosphorylation targets have been identified, an appreciable number of which are ion channels, implicating the possible involvement of p38 MAPK in neuronal excitability. The KNa channel Slack is an important protein to be studied as it is highly and ubiquitously expressed in DRG neurons and is import...
5 CitationsSource
#2Amy M. Gancarz-Kausch (UB: University at Buffalo)H-Index: 4
Last.Arin Bhattacharjee (UB: University at Buffalo)H-Index: 22
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Although recent studies have shown the sodium-activated potassium channel SLACK (KCNT1) can contribute to neuronal excitability, there remains little information on the physiological role of the closely related SLICK (KCNT2) channel. Activation of SLICK channels may be important during pathological states such as ischemia, in which an increase in intracellular sodium and chloride can perturb membrane potential and ion homeostasis. We have identified two NFκB-binding sites within the promoter reg...
6 CitationsSource
#1Kerri D. Pryce (UB: University at Buffalo)H-Index: 1
#2Dalia Agwa (UB: University at Buffalo)
Last.Arin Bhattacharjee (UB: University at Buffalo)H-Index: 22
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The sodium-activated potassium subunit Slack (Kcnt1) is highly expressed in sensory neurons and contributes to firing accommodation. Previous studies have shown that protein kinase A-induced intern...
#2Robert M. BradleyH-Index: 2
Last.Shiro NakamuraH-Index: 6
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