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Arin Bhattacharjee
State University of New York System
41Publications
22H-index
1,602Citations
Publications 41
Newest
Published on Mar 12, 2019in The FASEB Journal 5.59
Kerri D. Pryce (SUNY: State University of New York System), Rasheen Powell (SUNY: State University of New York System)+ 6 AuthorsArin Bhattacharjee22
Estimated H-index: 22
(SUNY: State University of New York System)
Voltage-dependent sodium (NaV) 1.8 channels regulate action potential generation in nociceptive neurons, identifying them as putative analgesic targets. Here, we show that NaV1.8 channel plasma membrane localization, retention, and stability occur through a direct interaction with the postsynaptic density-95/discs large/zonula occludens-1–and WW domain–containing scaffold protein called membrane-associated guanylate kinase with inverted orientation (Magi)-1. The neurophysiological roles of Magi-...
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Published on Nov 24, 2017in Journal of Biological Chemistry 4.01
Sushmitha Gururaj2
Estimated H-index: 2
(UB: University at Buffalo),
Katherine M. Evely3
Estimated H-index: 3
(UB: University at Buffalo)
+ 3 AuthorsArin Bhattacharjee22
Estimated H-index: 22
(UB: University at Buffalo)
Abstract The sodium-activated potassium (KNa) channel Kcnt1 (Slack) is abundantly expressed in nociceptor (pain sending) neurons of the dorsal root ganglion (DRG), where they transmit the large outward conductance IKNa and arbitrate membrane excitability. Slack channel expression at the DRG membrane is necessary for their characteristic firing accommodation during maintained stimulation, and reduced membrane channel density causes hyperexcitability. We have previously shown that in a pro-inflamm...
1 Citations Source Cite
Published on Oct 1, 2017in Cell Reports 8.03
Sushmitha Gururaj2
Estimated H-index: 2
(SUNY: State University of New York System),
Elizabeth E. Palmer9
Estimated H-index: 9
(UNSW: University of New South Wales)
+ 15 AuthorsYing Zhu7
Estimated H-index: 7
Summary Early infantile epileptic encephalopathies (EOEE) are a debilitating spectrum of disorders associated with cognitive impairments. We present a clinical report of a KCNT2 mutation in an EOEE patient. The de novo heterozygous variant Phe240Leu SLICK was identified by exome sequencing and confirmed by Sanger sequencing. Phe240Leu rSlick and hSLICK channels were electrophysiologically, heterologously characterized to reveal three significant alterations to channel function. First, [Cl − ] i ...
4 Citations Source Cite
Published on May 1, 2017in Neuroscience 3.38
Katherine M. Evely3
Estimated H-index: 3
(UB: University at Buffalo),
Kerri D. Pryce2
Estimated H-index: 2
(UB: University at Buffalo),
Arin Bhattacharjee22
Estimated H-index: 22
(UB: University at Buffalo)
Abstract Sodium-activated potassium (K Na ) channels contribute to firing frequency adaptation and slow after hyperpolarization. The KCNT1 gene (also known as SLACK ) encodes a K Na subunit that is expressed throughout the central and peripheral nervous systems. Missense mutations of the SLACK C-terminus have been reported in several patients with rare forms of early onset epilepsy and in some cases severely delayed myelination. To date, such mutations identified in patients with autosomal domin...
4 Citations Source Cite
Published on Jan 1, 2017in Molecular Pain 3.21
Katherine M. Evely3
Estimated H-index: 3
,
Kerri D. Pryce2
Estimated H-index: 2
+ 4 AuthorsArin Bhattacharjee22
Estimated H-index: 22
The sodium-activated potassium channel Slack (Kcnt1, Slo2.2) is highly expressed in dorsal root ganglion neurons where it regulates neuronal firing. Several studies have implicated the Slack channel in pain processing, but the precise mechanism or the levels within the sensory pathway where channels are involved remain unclear. Here, we furthered the behavioral characterization of Slack channel knockout mice and for the first time examined the role of Slack channels in the superficial, pain-proc...
3 Citations Source Cite
Published on Jan 1, 2017in Journal of Experimental Neuroscience
Danielle L. Tomasello1
Estimated H-index: 1
(SUNY: State University of New York System),
Edward Hurley1
Estimated H-index: 1
(SUNY: State University of New York System)
+ 1 AuthorsArin Bhattacharjee22
Estimated H-index: 22
(SUNY: State University of New York System)
The Slick (Kcnt2) sodium-activated potassium (KNa) channel is a rapidly gating and weakly voltage-dependent and sodium-dependent potassium channel with no clearly defined physiological function. Within the dorsal root ganglia (DRGs), we show Slick channels are exclusively expressed in small-sized and medium-sized calcitonin gene–related peptide (CGRP)-containing DRG neurons, and a pool of channels are localized to large dense-core vesicles (LDCV)-containing CGRP. We stimulated DRG neurons for CG...
1 Citations Source Cite
Published on Apr 1, 2016in Neuropharmacology 4.25
Sushmitha Gururaj2
Estimated H-index: 2
(SUNY: State University of New York System),
John Fleites1
Estimated H-index: 1
(SUNY: State University of New York System),
Arin Bhattacharjee22
Estimated H-index: 22
(SUNY: State University of New York System)
p38 MAPK has long been understood as an inducible kinase under conditions of cellular stress, but there is now increasing evidence to support its role in the regulation of neuronal function. Several phosphorylation targets have been identified, an appreciable number of which are ion channels, implicating the possible involvement of p38 MAPK in neuronal excitability. The KNa channel Slack is an important protein to be studied as it is highly and ubiquitously expressed in DRG neurons and is import...
4 Citations Source Cite
Published on Jul 24, 2015in Journal of Biological Chemistry 4.01
Danielle L. Tomasello5
Estimated H-index: 5
,
Amy M. Gancarz-Kausch4
Estimated H-index: 4
(UB: University at Buffalo)
+ 1 AuthorsArin Bhattacharjee22
Estimated H-index: 22
(UB: University at Buffalo)
Although recent studies have shown the sodium-activated potassium channel SLACK (KCNT1) can contribute to neuronal excitability, there remains little information on the physiological role of the closely related SLICK (KCNT2) channel. Activation of SLICK channels may be important during pathological states such as ischemia, in which an increase in intracellular sodium and chloride can perturb membrane potential and ion homeostasis. We have identified two NFκB-binding sites within the promoter reg...
6 Citations Source Cite
Published on Apr 1, 2015in The FASEB Journal 5.59
Kerri D. Pryce2
Estimated H-index: 2
(UB: University at Buffalo),
Dalia Agwa (UB: University at Buffalo)+ 1 AuthorsArin Bhattacharjee22
Estimated H-index: 22
(UB: University at Buffalo)
The sodium-activated potassium subunit Slack (Kcnt1) is highly expressed in sensory neurons and contributes to firing accommodation. Previous studies have shown that protein kinase A-induced internalization of Slack channels contributes to hyperexcitability in DRG neurons. These results suggest that the molecular modulators of Slack channel trafficking could serve as novel therapeutic targets in the treatment of pain. In this study, we probed the molecular determinants of Slack channel trafficki...
Published on Jan 1, 2015
Arturas Grigaliunas2
Estimated H-index: 2
,
Robert M. Bradley8
Estimated H-index: 8
+ 3 AuthorsShiro Nakamura5
Estimated H-index: 5
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