Hean Zhuang
Publications 5
High-voltage-activated (HVA) calcium channels are known to be the primary source of calcium for glucose-stimulated insulin secretion. However, few studies have investigated how these channels can be regulated by chronically elevated levels of glucose. In the present study, we determined the level of expression of the four major HVA calcium channels (N-type, P/Q-type, LC-type, and LD-type) in rat pancreatic β-cells. Using quantitative real-time PCR (QRT-PCR), we found the expression of all four H...
24 CitationsSource
#1Ming LiH-Index: 24
#2Min ZhangH-Index: 7
Last.Richard M WhitehurstH-Index: 6
view all 8 authors...
T-Type Ca 2+ Channels Are Involved in High Glucose–Induced Rat Neonatal Cardiomyocyte Proliferation
39 CitationsSource
Mibefradil is a Ca 2+ channel antagonist that inhibits both T-type and high-voltage-activated Ca 2+ channels. We previously showed that block of high-voltage-activated channels by mibefradil occurs through the production of an active metabolite by intracellular hydrolysis. In the present study, we modified the structure of mibefradil to develop a nonhydrolyzable analog, (1 S , 2 S )-2-(2-( N -[(3-benzimidazol-2-yl)propyl]- N -methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl c...
133 CitationsSource
#1Hean ZhuangH-Index: 4
#2Arin BhattacharjeeH-Index: 22
Last.Ming LiH-Index: 24
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The T-type Ca2+ channel is an important determinant of electrical activity and of Ca2+ influx in rat and human pancreatic beta-cells. We have identified and sequenced a cDNA encoding a T-type Ca2+ channel alpha1-subunit derived from INS-1, the rat insulin-secreting cell line. The sequence of the cDNA indicates a protein composed of 2,288 amino acids that shares 96.3% identity to alpha1G, the neuronal T-type Ca2+ channel subunit. The transmembrane domains of the protein are highly conserved, but ...
42 CitationsSource
#1Min ZhangH-Index: 7
#2Hean ZhuangH-Index: 4
Last.Richard M WhitehurstH-Index: 6
view all 5 authors...
High Glucose Increases [Ca 2+ ] i through an Increased Expression of T-Type Ca 2+ Channels in Neonatal Rat Cardiomyocytes