Review paper
Variability and Exclusion in Host and Parasite: Epigenetic Regulation of Ig and var Expression
Abstract
The immune system generates highly diverse AgRs of different specificities from a pool of designated genomic loci, each containing large arrays of genes. Ultimately, each B or T cell expresses a receptor of a single type on its surface. Immune evasion by the malaria parasite Plasmodium falciparum is mediated by the mutually exclusive expression of a single member of the var family of genes, which encodes variant surface Ags. In this review, we...
Paper Details
Title
Variability and Exclusion in Host and Parasite: Epigenetic Regulation of Ig and var Expression
Published Date
Nov 1, 2006
Journal
Volume
177
Issue
9
Pages
5767 - 5774
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