Yehudit Bergman
Hebrew University of Jerusalem
Molecular biologyDNA methylationEpigeneticsGeneticsBiology
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Publications 71
#1Ihab Ansari (HUJI: Hebrew University of Jerusalem)H-Index: 1
#2Günter Raddatz (DKFZ: German Cancer Research Center)H-Index: 10
Last. Eran Elinav (Weizmann Institute of Science)H-Index: 42
view all 12 authors...
Although much research has been done on the diversity of the gut microbiome, little is known about how it influences intestinal homeostasis under normal and pathogenic conditions. Epigenetic mechanisms have recently been suggested to operate at the interface between the microbiota and the intestinal epithelium. We performed whole-genome bisulfite sequencing on conventionally raised and germ-free mice, and discovered that exposure to commensal microbiota induced localized DNA methylation changes ...
5 CitationsSource
#1Tal Falick Michaeli (HUJI: Hebrew University of Jerusalem)H-Index: 2
#2Adam Spiro (HUJI: Hebrew University of Jerusalem)H-Index: 3
Last. Yuval Gielchinsky (HUJI: Hebrew University of Jerusalem)H-Index: 10
view all 9 authors...
#1Nofar Mor (Weizmann Institute of Science)H-Index: 4
#2Yoach Rais (Weizmann Institute of Science)H-Index: 10
Last. Jacob H. Hanna (Weizmann Institute of Science)H-Index: 44
view all 30 authors...
Summary Mbd3, a member of nucleosome remodeling and deacetylase (NuRD) co-repressor complex, was previously identified as an inhibitor for deterministic induced pluripotent stem cell (iPSC) reprogramming, where up to 100% of donor cells successfully complete the process. NuRD can assume multiple mutually exclusive conformations, and it remains unclear whether this deterministic phenotype can be attributed to a specific Mbd3/NuRD subcomplex. Moreover, since complete ablation of Mbd3 blocks somati...
10 CitationsSource
#1Felix BormannH-Index: 4
Last. Frank LykoH-Index: 1
view all 10 authors...
#1Felix Bormann (DKFZ: German Cancer Research Center)H-Index: 4
#2Manuel Rodríguez-Paredes (DKFZ: German Cancer Research Center)H-Index: 11
Last. Frank Lyko (DKFZ: German Cancer Research Center)H-Index: 53
view all 12 authors...
Summary Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, provide opportunities for the molecular analysis of tumors. We have now analyzed DNA methylation patterns in colorectal adenomas and identified three biologically defined subclasses that describe different intestinal crypt differentiation stages. Importan...
6 CitationsSource
#1Nofar Mor (Weizmann Institute of Science)H-Index: 4
#2Yoach Rais (Weizmann Institute of Science)H-Index: 10
Last. Jacob H. Hanna (Weizmann Institute of Science)H-Index: 44
view all 28 authors...
The Nucleosome Remodeling and Deacytelase (NuRD) complex is a co-repressive complex involved in many pathological and physiological processes in the cell. Previous studies have identified one of its components, Mbd3, as a potent inhibitor for reprogramming of somatic cells to pluripotency. Following OSKM induction, early and partial depletion of Mbd3 protein followed by applying naive ground-state pluripotency conditions, results in a highly efficient and near-deterministic generation of mouse i...
1 CitationsSource
Asynchronous replication-timing patterns undergo programmed switching between maternal and paternal alleles in embryonic and adult stem cells.
4 CitationsSource
#1Felix BormannH-Index: 4
Last. Frank LykoH-Index: 53
view all 5 authors...
#1Rena Levin-KleinH-Index: 5
#2Shira FraenkelH-Index: 4
Last. Yehudit BergmanH-Index: 36
view all 10 authors...
B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochastic activation of V gene segments to induce optimal generation of a diverse repertoire.
5 CitationsSource
#1Shari Orlanski (HUJI: Hebrew University of Jerusalem)H-Index: 6
#2Verena LabiH-Index: 21
Last. Yehudit Bergman (HUJI: Hebrew University of Jerusalem)H-Index: 36
view all 11 authors...
There is ample evidence that somatic cell differentiation during development is accompanied by extensive DNA demethylation of specific sites that vary between cell types. Although the mechanism of this process has not yet been elucidated, it is likely to involve the conversion of 5mC to 5hmC by Tet enzymes. We show that a Tet2/Tet3 conditional knockout at early stages of B-cell development largely prevents lineage-specific programmed demethylation events. This lack of demethylation affects the e...
36 CitationsSource