Journal of Immunology
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#1Pierre-Gregoire Coulon (UCI: University of California, Irvine)H-Index: 2
#2Soumyabrata Roy (UCI: University of California, Irvine)H-Index: 2
Last. Angela M. Nguyen (UCI: University of California, Irvine)H-Index: 1
view all 15 authors...
A large proportion of the world's population harbors latent HSV type 1 (HSV-1). Cross-talk between antiviral CD8+ T cells and HSV-1 appear to control latency/reactivation cycles. We found that compared with healthy asymptomatic individuals, in symptomatic (SYMP) patients, the CD8+ T cells with the same HLA-A*0201-restricted HSV-1 epitope specificities expressed multiple genes and proteins associated to major T cell exhaustion pathways and were dysfunctional. Blockade of immune checkpoints with a...
#2Ajay Suresh AkhadeH-Index: 3
Last. Ayub QadriH-Index: 11
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Pathogenic Salmonella serovars produce clinical manifestations ranging from systemic infection typhoid to invasive nontyphoidal Salmonella disease in humans. These serovars share a high degree of homology at the genome and the proteome level. However, whether infection or immunization with one serovar provides protection against other serovars has not been well studied. We show in this study that immunization of mice with live typhoidal serovar, Salmonella Typhi, generates cross-reactive immune ...
#1Jelani Clarke (Montreal Neurological Institute and Hospital)
#2Moein Yaqubi (Montreal Neurological Institute and Hospital)
Last. John H. White (McGill University)H-Index: 43
view all 11 authors...
Vitamin D deficiency is a major environmental risk factor for the development of multiple sclerosis. The major circulating metabolite of vitamin D (25-hydroxyvitamin D) is converted to the active form (calcitriol) by the hydroxylase enzyme CYP27B1 In multiple sclerosis lesions, the tyrosine kinase MerTK expressed by myeloid cells regulates phagocytosis of myelin debris and apoptotic cells that can accumulate and inhibit tissue repair and remyelination. In this study, we explored the effect of ca...
#1Kevin Tsai (UBC: University of British Columbia)H-Index: 4
#2Yu-Hsuan Huang (UBC: University of British Columbia)H-Index: 2
Last. John J. Priatel (UBC: University of British Columbia)H-Index: 19
view all 7 authors...
A layer of mucus functions to segregate contents of the intestinal lumen from the intestinal epithelium. The MUC2 mucin is the primary constituent of intestinal mucus and plays critical protective roles against luminal microbes and other noxious agents. In this study, we investigated whether MUC2 helps maintain CD8 T cell tolerance toward intestinal luminal Ags by gavaging wild-type and Muc2-/- mice with a model Ag and monitoring immune responses posttreatment. We report that orally delivered OV...
#1S. Marina Casalino-Matsuda (NU: Northwestern University)H-Index: 3
#2Fei Chen (NU: Northwestern University)
Last. Peter H. S. Sporn (NU: Northwestern University)H-Index: 27
view all 10 authors...
Hypercapnia (HC), elevation of the partial pressure of CO2 in blood and tissues, is a risk factor for mortality in patients with severe acute and chronic lung diseases. We previously showed that HC inhibits multiple macrophage and neutrophil antimicrobial functions and increases the mortality of bacterial pneumonia in mice. In this study, we show that normoxic HC increases viral replication, lung injury, and mortality in mice infected with influenza A virus (IAV). Elevated CO2 increased IAV repl...
#1Kamala Vanarsa (UH: University of Houston)H-Index: 8
#2Jared Henderson (UH: University of Houston)
Last. Chandra Mohan (UH: University of Houston)H-Index: 49
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Our recent study has implicated bradykinin (BK) signaling as being of pathogenic importance in lupus. This study aims to investigate the biomarker potential of BK peptides, BK and BK-des-arg-9, in lupus and other rheumatic autoimmune diseases. Sera from systemic lupus erythematosus (SLE) patients and healthy subjects were screened for BK and BK-des-arg-9 by liquid chromatography-mass spectrometry metabolomics. Serum from 6-mo-old C57BL/6 mice and three murine lupus strains were also screened for...
#1Tiffany Blair (OHSU: Oregon Health & Science University)H-Index: 3
#2Shelly Bambina (Providence Portland Medical Center)H-Index: 12
Last. Marka R. Crittenden (Providence Portland Medical Center)H-Index: 21
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Radiation therapy is capable of directing adaptive immune responses against tumors by stimulating the release of endogenous adjuvants and tumor-associated Ags. Within the tumor, conventional type 1 dendritic cells (cDC1s) are uniquely positioned to respond to these signals, uptake exogenous tumor Ags, and migrate to the tumor draining lymph node to initiate cross-priming of tumor-reactive cytotoxic CD8(+) T cells. In this study, we report that radiation therapy promotes the activation of intratu...
#1Sampsa Matikainen (UH: University of Helsinki)H-Index: 54
#2Tuula A. Nyman (University of Oslo)H-Index: 33
Last. Wojciech Cypryk (PAN: Polish Academy of Sciences)H-Index: 5
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Inflammasomes are multiprotein complexes of the innate immune system that orchestrate development of inflammation by activating the secretion of proinflammatory cytokines, IL-1β and IL-18. The LPS of Gram-negative bacteria have been shown to activate a novel, noncanonical inflammasome by directly binding in the cytosol to human caspase-4 and mouse caspase-11. Activation of noncanonical inflammasome exerts two major effects: it activates the NLRP3-caspase-1-mediated processing and secretion of IL...
#1Judith Schick (FAU: University of Erlangen-Nuremberg)H-Index: 2
#2Johanna Schäfer (FAU: University of Erlangen-Nuremberg)
Last. Roland Lang (FAU: University of Erlangen-Nuremberg)H-Index: 53
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TNF blockade is a successful treatment for human autoimmune disorders like rheumatoid arthritis and inflammatory bowel disease yet increases susceptibility to tuberculosis and other infections. The C-type lectin receptors (CLR) MINCLE, MCL, and DECTIN-2 are expressed on myeloid cells and sense mycobacterial cell wall glycolipids. In this study, we show that TNF is sufficient to upregulate MINCLE, MCL, and DECTIN-2 in macrophages. TNF signaling through TNFR1 p55 was required for upregulation of t...
#1Taylor Schmit (UND: University of North Dakota)
#2Sumit Ghosh (Nationwide Children's Hospital)
Last. M. Nadeem Khan (UND: University of North Dakota)H-Index: 7
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Allergic asthma (AA) is characterized as a Th2-biased airway inflammation that can develop lung inflammation and remodeling of the respiratory tract. Streptococcus pneumoniae is a major respiratory pathogen, causing noninvasive (otitis media and pneumonia) and invasive diseases (sepsis) in humans. We sought to determine the role of IL-6 in the regulation of lung inflammation in murine AA caused by Aspergillus fumigatus as well as its consequence on the regulation of airway barrier integrity and ...
Top fields of study
Molecular biology
T cell
Immune system