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Shira Fraenkel
Hebrew University of Jerusalem
AntibodyImmunologyGeneticsBiologyImmune system
7Publications
4H-index
170Citations
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Publications 7
Newest
#1Rena Levin-KleinH-Index: 5
#2Shira FraenkelH-Index: 4
Last. Yehudit BergmanH-Index: 37
view all 10 authors...
B cell development involves sequential rearrangement of the immunoglobulin chains, but fine control over the selection process remains a mystery. Here the authors show that individual alleles in pre-B cells are clonally unique and result from stochastic activation of V gene segments to induce optimal generation of a diverse repertoire.
5 CitationsSource
#1Marganit FaragoH-Index: 8
#2Chaggai RosenbluhH-Index: 2
Last. Yehudit BergmanH-Index: 37
view all 16 authors...
Immunoglobulin genes are expressed from either the maternal or paternal chromosome; it is now shown that in early haematopoietic stem cells, an individual cell can choose either of the two alleles, but as they develop they become committed to only one.
34 CitationsSource
#1Shira Fraenkel (HUJI: Hebrew University of Jerusalem)H-Index: 4
#2Raul Mostoslovasky (Harvard University)H-Index: 50
Last. Yehudit Bergman (HUJI: Hebrew University of Jerusalem)H-Index: 37
view all 11 authors...
Allelic 'choice' governs somatic hypermutation in vivo at the immunoglobulin κ-chain locus
50 CitationsSource
#1Shira Fraenkel (HUJI: Hebrew University of Jerusalem)H-Index: 4
#2Yehudit Bergman (HUJI: Hebrew University of Jerusalem)H-Index: 37
The immune system generates highly diverse AgRs of different specificities from a pool of designated genomic loci, each containing large arrays of genes. Ultimately, each B or T cell expresses a receptor of a single type on its surface. Immune evasion by the malaria parasite Plasmodium falciparum is mediated by the mutually exclusive expression of a single member of the var family of genes, which encodes variant surface Ags. In this review, we discuss the similarities as well as the unique chara...
2 CitationsSource
#1Ariel MunitzH-Index: 27
#2Ido BacheletH-Index: 14
Last. Francesca Levi-SchafferH-Index: 57
view all 9 authors...
Eosinophils are present in parasitic, allergic, various immunological, and malignant disorders as well as in a variety of idiopathic hypereosinophilic syndromes. However, their exact role in some of these conditions remains elusive. They can be activated both in vivo and in vitro by various agonists, such as Igs, lipid mediators, and cytokines. By phenotyping the surface of the eosinophils, it may be possible to better define their function(s) in different pathophysiological settings. In the pre...
77 CitationsSource
#1Ariel Munitz (HUJI: Hebrew University of Jerusalem)H-Index: 27
#2Shira Fraenkel (HUJI: Hebrew University of Jerusalem)H-Index: 4
Last. Francesca Levi-Schaffer (HUJI: Hebrew University of Jerusalem)H-Index: 57
view all 6 authors...
Abstract Rationale Complex networks of activating and inhibitory signals likely control the immunological/inflammatory responses coordinated by eosinophils. The CD2-subfamily of the Ig-superfamily, expressed mainly on NK and T cell subsets, includes 2B4, CD48, SLAM and NTB-A. CD48 is a high-affinity ligand for 2B4. Activation of 2B4, SLAM and NTB-A causes tyrosine phosphorylation and recruitment of SAP. We have previously shown that eosinophils express functional 2B4. We examined the expression ...
Source
#1Shira Fraenkel (HUJI: Hebrew University of Jerusalem)H-Index: 4
#2Ilaria Puxeddu (HUJI: Hebrew University of Jerusalem)H-Index: 13
Last. Francesca Levi-Schaffer (HUJI: Hebrew University of Jerusalem)H-Index: 57
view all 3 authors...
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