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Course trajectories of unipolar depressive disorders identified by latent class growth analysis

Published on Jul 1, 2012in Psychological Medicine 5.64
· DOI :10.1017/S0033291711002509
Didi Rhebergen13
Estimated H-index: 13
(VUmc: VU University Medical Center),
Femke Lamers25
Estimated H-index: 25
(VUmc: VU University Medical Center)
+ 3 AuthorsBrenda W. J. H. Penninx126
Estimated H-index: 126
(VUmc: VU University Medical Center)
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Abstract
Background Current classification of unipolar depression reflects the idea that prognosis is essential. However, do DSM categories of major depressive disorder (MDD), dysthymic disorder (Dysth) and double depression (DD=MDD+Dysth) indeed adequately represent clinically relevant course trajectories of unipolar depression? Our aim was to test DSM categories (MDD, Dysth and DD) in comparison with empirically derived prognostic categories, using a prospectively followed cohort of depressed patients.Method A large sample (n=804) of out-patients with unipolar depression were derived from a prospective cohort study, the Netherlands Study of Depression and Anxiety (NESDA). Using latent class growth analysis (LCGA), empirically derived 2-year course trajectories were constructed. These were compared with DSM diagnoses and a wider set of putative predictors for class membership.Results Five course trajectories were identified, ranging from mild severity and rapid remission to high severity and chronic course trajectory. Contrary to expectations, more than 50% of Dysth and DD were allocated to classes with favorable course trajectories, suggesting that current DSM categories do not adequately represent course trajectories. The class with the most favorable course trajectory differed on several characteristics from other classes (younger age, more females, less childhood adversity, less somatic illnesses, lower neuroticism, higher extraversion). Older age, earlier age of onset and lower extraversion predicted poorest course trajectory.Conclusions MDD, Dysth and DD did not adequately match empirically derived course trajectories for unipolar depression. For the future classification of unipolar depression, it may be wise to retain the larger, heterogeneous category of unipolar depression, adopting cross-cutting dimensions of severity and duration to further characterize patients. © 2011 Cambridge University Press.
  • References (47)
  • Citations (42)
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References47
Newest
Published on Jan 1, 2012in Comprehensive Psychiatry 2.59
Femke Lamers25
Estimated H-index: 25
(VUmc: VU University Medical Center),
Adriaan W. Hoogendoorn14
Estimated H-index: 14
(VUmc: VU University Medical Center)
+ 4 AuthorsBrenda W. J. H. Penninx126
Estimated H-index: 126
(VUmc: VU University Medical Center)
Abstract Background Although attrition is inevitable in longitudinal epidemiological studies, psychiatric studies are thought to be especially sensitive to attrition. This study aimed to evaluate the sociodemographic and psychiatric determinants of attrition at 2-year follow-up in the Netherlands Study of Depression and Anxiety. Methods Logistic regression was used to examine sociodemographic and psychiatric determinants of attrition and the influence of clinical psychiatric characteristics on a...
94 Citations Source Cite
Published on Apr 1, 2011in Acta Psychiatrica Scandinavica 4.69
Didi Rhebergen13
Estimated H-index: 13
(VUmc: VU University Medical Center),
Neeltje M. Batelaan16
Estimated H-index: 16
(VUmc: VU University Medical Center)
+ 4 AuthorsBrenda W. J. H. Penninx126
Estimated H-index: 126
(VUmc: VU University Medical Center)
Objective: Insight into the long-term course of depression and anxiety. Method: Data were derived from Netherlands Mental Health Survey and Incidence Study/Netherlands Study of Depression and Anxiety, epidemiologic surveys in the adult population in the Netherlands. Three hundred and three respondents with depressive and/or anxiety Composite International Diagnostic Interview (CIDI) disorder were interviewed, examining the 7-year course of depression (n = 141), anxiety (n = 102) and the comorbid...
67 Citations Source Cite
Published on Mar 15, 2011in The Journal of Clinical Psychiatry 4.02
Jenneke Wiersma7
Estimated H-index: 7
(VU: VU University Amsterdam),
Patricia van Oppen37
Estimated H-index: 37
(VU: VU University Amsterdam)
+ 3 AuthorsBrenda W. J. H. Penninx126
Estimated H-index: 126
(LEI: Leiden University)
Background: Few studies have investigated the importance of psychological characteristics for chronicity of depression. Knowledge about psychological differences between chronically depressed persons and nonchronically depressed persons may help to improve treatment of chronic depression. This is the first study to simultaneously compare in large samples various psychological characteristics between chronically depressed and nonchronically depressed adults. Method: Baseline data were drawn from ...
55 Citations Source Cite
Published on Dec 1, 2010in BMC Public Health 2.57
Anni Skipstein5
Estimated H-index: 5
,
Harald Janson7
Estimated H-index: 7
+ 1 AuthorsKristin S. Mathiesen12
Estimated H-index: 12
Background There is a lack of population-based studies of developmental trajectories following mothers throughout the whole child-rearing phase and there are few longitudinal studies focusing on both symptoms of depression and anxiety. The aim of the current study is to identify latent trajectory groups based on counts of symptoms of anxiety and depression among mothers throughout the child-rearing phase and the relations of the latent groups to maternal socio-demographic variables.
33 Citations Source Cite
Published on May 1, 2010in Comprehensive Psychiatry 2.59
Thomas M. Olino31
Estimated H-index: 31
(SBU: Stony Brook University),
Daniel N. Klein72
Estimated H-index: 72
(SBU: Stony Brook University)
+ 2 AuthorsJohn R. Seeley79
Estimated H-index: 79
(Oregon Research Institute)
Abstract This study used person-oriented analyses to identify subgroups of individuals who exhibit different patterns of depressive and anxiety disorders over the course of adolescence and young adulthood. Using latent class growth analysis, six trajectory classes were identified. Two classes were mainly characterized by depressive disorders; one class was mainly characterized by anxiety disorders; two classes were characterized by temporally different patterns of comorbidity; and one class was ...
66 Citations Source Cite
Published on Dec 1, 2009in BMC Psychiatry 2.67
Arijit Nandi23
Estimated H-index: 23
(Harvard University),
John L. Beard72
Estimated H-index: 72
(SCU: Southern Cross University),
Sandro Galea85
Estimated H-index: 85
Background Clinical evidence has long suggested there may be heterogeneity in the patterns and predictors of common mood and anxiety disorders; however, epidemiologic studies have generally treated these outcomes as homogenous entities. The objective of this study was to systematically review the epidemiologic evidence for potential patterns of heterogeneity of common mood and anxiety disorders over the lifecourse in the general population.
69 Citations Source Cite
Published on Oct 1, 2009in Psychological Medicine 5.64
M. Vuorilehto11
Estimated H-index: 11
,
Tarja Melartin26
Estimated H-index: 26
,
Erkki Isometsä60
Estimated H-index: 60
Method. In The Vantaa Primary Care Depression Study (PC-VDS), 1111 consecutive primary-care patients were screened for depression with the Prime-MD screen, and 137 diagnosed with DSM-IV depressive disorders by interviewing with the Structured Clinical Interview for DSM-IV (SCID)-I/P and SCID-II. This cohort was prospectively followed-up at 3, 6 and 18 months. Altogether 123 patients (90 %) completed the 18-month follow-up, including 79 with major depressive disorder (MDD) and 44 with subsyndroma...
64 Citations Source Cite
Published on Jul 15, 2009in The Journal of Clinical Psychiatry 4.02
Jenneke Wiersma7
Estimated H-index: 7
(VU: VU University Amsterdam),
Jacqueline G. F. M. Hovens10
Estimated H-index: 10
(LEI: Leiden University)
+ 4 AuthorsBrenda W. J. H. Penninx126
Estimated H-index: 126
Background: Childhood trauma is linked to adult depression and might be a risk factor for a more chronic course of depression. However, the link between childhood trauma and chronicity of depression has not been investigated using a large and representative sample in which other depression characteristics, such as severity; age at onset, and comorbid psychopathology, were taken into account. Method: Baseline data, collected during 2004 through 2007, were drawn from the Netherlands Study of Depre...
180 Citations Source Cite
Published on Jul 1, 2009in Journal of Nervous and Mental Disease 1.86
E Jenna Robison1
Estimated H-index: 1
(UIC: University of Illinois at Chicago),
Stewart A. Shankman24
Estimated H-index: 24
,
Brian R. McFarland4
Estimated H-index: 4
Few studies have examined age of onset and chronicity of depression in the same subject sample. The present study sought to determine whether personality traits related to early onset depression were different from those related to chronic depression. We tested the associations between personality self-reports and clinical characteristics of depression by conducting multiple and logistic regression analyses to determine whether personality uniquely predicted clinical characteristics and whether ...
14 Citations Source Cite
Published on Jun 1, 2009in Journal of Affective Disorders 4.08
Didi Rhebergen13
Estimated H-index: 13
(VUmc: VU University Medical Center),
Amy Beekman87
Estimated H-index: 87
(VUmc: VU University Medical Center)
+ 4 AuthorsBrenda W. J. H. Penninx126
Estimated H-index: 126
(VUmc: VU University Medical Center)
Abstract Background Recent studies support a distinction between acute and chronic forms of depression, which contrasts the single-disease hypothesis for depressive disorders. Insight into the (determinants of) the 3-year naturalistic course of major depressive disorder (MDD), dysthymic disorder (Dysth) and double depression (DD) may contribute to this debate. Methods Data were derived from NEMESIS, an epidemiologic survey in the adult population of the Netherlands. 400 Respondents who met the C...
57 Citations Source Cite
Cited By42
Newest
Published on May 1, 2019in Psychoneuroendocrinology 4.01
Kevin K. Chopra5
Estimated H-index: 5
(U of T: University of Toronto),
Jasmin L. Katz (Queen's University)+ 3 AuthorsRobert D. Levitan43
Estimated H-index: 43
(U of T: University of Toronto)
Abstract Background Chronic Major Depressive Disorder (CMDD) is a common, disabling illness that is often complicated by high reactivity to social stress. To further elucidate the nature of this reactivity, the current study evaluated whether the personality dimensions of neuroticism and extraversion influenced cortisol responses to a social challenge in CMDD patients vs. controls. Methods Fifty participants with CMDD and 58 healthy controls completed the Trier Social Stress Test (TSST) using a ...
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Published on Apr 4, 2019in PLOS ONE 2.78
Chiara Marzorati2
Estimated H-index: 2
,
D Monzani10
Estimated H-index: 10
+ 5 AuthorsGabriella Pravettoni19
Estimated H-index: 19
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Published on Apr 1, 2019in Drugs 4.99
Hans Wouters12
Estimated H-index: 12
(UG: University of Groningen),
Didi Rhebergen + 4 AuthorsHelga Gardarsdottir12
Estimated H-index: 12
(UU: Utrecht University)
Objective A recurrent observation is that associations between self-reported and objective medication adherence measures are often weak to moderate. Our aim was therefore to identify patients with different profiles on self-reported and objective adherence measures.
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Published on Mar 1, 2019in JAMA Psychiatry 15.92
Frances Rice35
Estimated H-index: 35
(Medical Research Council),
Lucy Riglin7
Estimated H-index: 7
+ 4 AuthorsAnita Thapar3
Estimated H-index: 3
(UoB: University of Bristol)
Importance Depression often first manifests in adolescence. Thereafter, individual trajectories vary substantially, but it is not known what shapes depression trajectories in youth. Adult studies suggest that genetic risk for schizophrenia, a psychiatric disorder with a neurodevelopmental component, may contribute to an earlier onset of depression. Objective To test the hypothesis that there are distinct trajectories of depressive symptoms and that genetic liability for neurodevelopmental psychi...
5 Citations Source Cite
Published on Dec 1, 2018in Translational Psychiatry 5.18
Richard Dinga1
Estimated H-index: 1
(VU: VU University Amsterdam),
Andre F. Marquand28
Estimated H-index: 28
(Radboud University Nijmegen)
+ 5 AuthorsLianne Schmaal21
Estimated H-index: 21
(University of Melbourne)
Many variables have been linked to different course trajectories of depression. These findings, however, are based on group comparisons with unknown translational value. This study evaluated the prognostic value of a wide range of clinical, psychological, and biological characteristics for predicting the course of depression and aimed to identify the best set of predictors. Eight hundred four unipolar depressed patients (major depressive disorder or dysthymia) patients were assessed on a set inv...
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Published on Oct 26, 2018in bioRxiv
The Diagnostic and Statistical Manual of Mental Disorders (DSM) is the standard for diagnosing psychiatric disorders in the United States. However, evidence has suggested that symptoms in psychiatric disorders are not restricted to the boundaries between DSM categories, implying an underlying latent transdiagnostic structure of psychopathology. Here, we applied an importance-guided machine learning technique for model selection to item-level data from self-reported instruments contained within t...
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Published on Sep 7, 2018in PLOS ONE 2.78
Juliana J. Petersen12
Estimated H-index: 12
,
Johannes Hartig1
Estimated H-index: 1
+ 6 AuthorsJochen Gensichen22
Estimated H-index: 22
Purpose: Collaborative care is effective in improving symptoms of patients with depression. The aims of this study were to characterize symptom trajectories in patients with major depression during one year of collaborative care and to explore associations between baseline characteristics and symptom trajectories. Methods: We conducted a cluster-randomized controlled trial in primary care. The collaborative care intervention comprised case management and behavioral activation. We used the Patien...
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Published on Sep 1, 2018in American Journal of Geriatric Psychiatry 3.49
Hans W. Jeuring3
Estimated H-index: 3
(VUmc: VU University Medical Center),
Max L. Stek31
Estimated H-index: 31
(VUmc: VU University Medical Center)
+ 7 AuthorsHannie C. Comijs34
Estimated H-index: 34
(VUmc: VU University Medical Center)
Objectives To examine the six-year prognosis of patients with late-life depression and to identify prognostic factors of an unfavorable course. Design and Setting The Netherlands Study of Depression in Older Persons (NESDO) is a multisite naturalistic prospective cohort study with six-year follow-up. Participants Three hundred seventy-eight clinically depressed patients (according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Text Revision criteria) and 132 nondepresse...
3 Citations Source Cite
Published on Jun 3, 2018in Emerging adulthood
Jason D. Edgerton9
Estimated H-index: 9
(UM: University of Manitoba),
Souradet Y. Shaw17
Estimated H-index: 17
(UM: University of Manitoba),
Lance W. Roberts16
Estimated H-index: 16
(UM: University of Manitoba)
1 Citations Source Cite