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Brenda W. J. H. Penninx
Public Health Research Institute
1,114Publications
126H-index
62.1kCitations
Publications 1114
Newest
Published on Jan 1, 2019in Scientific Reports 4.01
Johanna H. M. Hovenkamp-Hermelink1
Estimated H-index: 1
(UMCG: University Medical Center Groningen),
Date C. van der Veen5
Estimated H-index: 5
(UMCG: University Medical Center Groningen)
+ 5 AuthorsHarriette Riese30
Estimated H-index: 30
(UMCG: University Medical Center Groningen)
Anxiety sensitivity is associated with the onset of panic attacks, anxiety, and other common mental disorders. Anxiety sensitivity is usually seen as a relative stable trait. However, previous studies were inconclusive regarding the longitudinal stability of anxiety sensitivity and differed in study designs and outcomes. The current study examines the stability of anxiety sensitivity over time and its longitudinal associations with severity of anxiety symptoms. Participants from the Netherlands ...
Published in Translational Psychiatry 5.18
Hilde de Kluiver (PHRI: Public Health Research Institute), R. F. Jansen31
Estimated H-index: 31
(VU: VU University Amsterdam)
+ -3 AuthorsBrenda W. J. H. Penninx126
Estimated H-index: 126
(PHRI: Public Health Research Institute)
The pathophysiology of major depressive disorder (MDD) is highly heterogeneous. Previous evidence at the DNA level as well as on the serum protein level suggests that the role of inflammation in MDD pathology is stronger in patients with hyperphagia during an active episode. Which inflammatory pathways differ in MDD patients with hyperphagia inflammatory pathways in terms of gene expression is unknown. We analyzed whole-blood gene expression profiles of 881 current MDD cases and 331 controls fro...
Published in Journal of Affective Disorders 4.08
Nienke J. de Bles (LUMC: Leiden University Medical Center), Nathaly Rius-Ottenheim5
Estimated H-index: 5
(LUMC: Leiden University Medical Center)
+ -3 AuthorsErik J. Giltay51
Estimated H-index: 51
(LUMC: Leiden University Medical Center)
Abstract Background Patients with various psychiatric disorders may suffer from feelings of anger, sometimes leading to maladaptive (e.g., aggressive) behaviors. We examined to what extent depressive and anxiety disorders, relevant clinical correlates, and sociodemographics determined the level of trait anger and the prevalence of recent anger attacks. Methods In the Netherlands Study of Depression and Anxiety (NESDA), the Spielberger Trait Anger Subscale and the Anger Attacks Questionnaire were...
Published on Jan 22, 2019in Nature Communications 11.88
Tuomas O. Kilpelaeinen31
Estimated H-index: 31
(ISMMS: Icahn School of Medicine at Mount Sinai),
Amy R. Bentley15
Estimated H-index: 15
(NIH: National Institutes of Health)
+ 234 AuthorsIoanna Ntalla27
Estimated H-index: 27
(QMUL: Queen Mary University of London)
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
Published in Translational Psychiatry 5.18
Breno S. Diniz34
Estimated H-index: 34
(U of T: University of Toronto),
Charles F. Reynolds102
Estimated H-index: 102
(University of Pittsburgh)
+ -3 AuthorsBrenda W. J. H. Penninx126
Estimated H-index: 126
(PHRI: Public Health Research Institute)
Recent evidence suggests a significant overlap in biological changes between major depression and aging across the lifespan. We aim to evaluate the impact of a major depressive episode on the Senescence-Associated Secretory Phenotype (SASP) index, a dynamic secretory molecular pattern indicative of cellular senescence. We also tested the potential moderators of the association between major depression and the SASP index. We included 1165 young and middle-aged adults (527 with a current major dep...
Published on Dec 1, 2019in Nature Communications 11.88
E. Porcu27
Estimated H-index: 27
(Swiss Institute of Bioinformatics),
Sina Rüeger9
Estimated H-index: 9
(Swiss Institute of Bioinformatics)
+ 3 AuthorsZoltán Kutalik51
Estimated H-index: 51
(Swiss Institute of Bioinformatics)
Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most of these variants overlap with expression QTLs, indicating their potential involvement in regulation of gene expression. Here, we propose a transcriptome-wide summary statistics-based Mendelian Randomization approach (TWMR) that uses multiple SNPs as instruments and multiple gene expression traits as exposures, simultaneously...
Published on Dec 1, 2019in Nature Communications 11.88
Darina Czamara26
Estimated H-index: 26
(MPG: Max Planck Society),
Gökcen Eraslan2
Estimated H-index: 2
(TUM: Technische Universität München)
+ 226 AuthorsRebecca M. Reynolds62
Estimated H-index: 62
(BHF: British Heart Foundation)
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overal...
Published on Oct 1, 2019in Journal of Affective Disorders 4.08
Liia Kivelä2
Estimated H-index: 2
(LEI: Leiden University),
Annegret Krause-Utz12
Estimated H-index: 12
(LEI: Leiden University)
+ 7 AuthorsNiki Antypa18
Estimated H-index: 18
(LEI: Leiden University)
Abstract Background Prior research indicates that the factors that trigger suicidal ideation may differ from those that maintain it, but studies into the maintenance of suicidal ideation remain scarce. Our aim was to assess the longitudinal course of suicidal ideation, and to identify predictors of persistent suicidal ideation. Methods We used data from the Netherlands Study of Depression and Anxiety (NESDA). We performed a linear mixed-effects growth model analysis (n=230 with current suicidal ...
Published in Health & Place 3.20
I. Motoc (PHRI: Public Health Research Institute), Erik J. Timmermans4
Estimated H-index: 4
(PHRI: Public Health Research Institute)
+ -3 AuthorsMartijn Huisman34
Estimated H-index: 34
(PHRI: Public Health Research Institute)
Abstract We examined the long-term association between objective neighbourhood sociodemographic characteristics (index of socioeconomic position (SEP), average income, percent low-income earners, average house price, percent immigrants and urban density) with depressive and anxiety symptoms, covering five 3-year waves of the Longitudinal Aging Study Amsterdam (n = 3,772). Multi-level regression models assessed each neighbourhood-level characteristic separately, adjusting for individual-level cov...
Published on Sep 1, 2019in Journal of Psychiatric Research 3.92
Denise Hanssen4
Estimated H-index: 4
(UMCG: University Medical Center Groningen),
Inge M. Rabeling-Keus2
Estimated H-index: 2
(Radboud University Nijmegen)
+ 5 AuthorsRichard C. Oude Voshaar (VUmc: VU University Medical Center)
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