Fas (CD95) expression in myeloid cells promotes obesity‐induced muscle insulin resistance

Low‐grade inflammation in adipose tissue and liver has been implicated in obesity‐associated insulin resistance and type 2 diabetes. Yet, the contribution of inflammatory cells to the pathogenesis of skeletal muscle insulin resistance remains elusive. In a large cohort of obese human individuals, blood monocyte Fas ( CD 95 ) expression correlated with systemic and skeletal muscle insulin resistance. To test a causal role for myeloid cell Fas...