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Stephan Wueest
Boston Children's Hospital
36Publications
15H-index
1,250Citations
Publications 36
Newest
Published on Oct 1, 2018in The Journal of Physiology
Gerald Grandl4
Estimated H-index: 4
,
Leon G. Straub5
Estimated H-index: 5
+ 4 AuthorsChristian Wolfrum29
Estimated H-index: 29
KEY POINTS A ketogenic diet is known to lead to weight loss and is considered metabolically healthy; however there are conflicting reports on its effect on hepatic insulin sensitivity. KD fed animals appear metabolically healthy in the fasted state after 3 days of dietary challenge, whereas obesogenic high-fat diet (HFD) fed animals show elevated insulin levels. A glucose challenge reveals that both KD and HFD fed animals are glucose intolerant. Glucose intolerance correlates with increased lipi...
3 Citations Source Cite
Published on Jul 3, 2018
Stephan Wueest15
Estimated H-index: 15
(Boston Children's Hospital),
Daniel Konrad27
Estimated H-index: 27
(UZH: University of Zurich)
ABSTRACTHigh secretion of interleukin (IL)-6 from white adipose tissue may contribute to metabolic complications in obesity. We have recently shown that IL-6-type cytokine signaling in adipocytes is involved in the development of obesity-associated hepatic insulin resistance and steatosis. In addition, we revealed that adipocyte-specific IL-6 signaling ameliorates glucose metabolism in obesity via enhancing insulin secretion. Mechanistically, IL-6 induces the release of free fatty acid (FFA) and...
1 Citations Source Cite
Published on Jul 1, 2018in Immunity 19.73
Marko Šestan4
Estimated H-index: 4
(University of Rijeka),
Sonja Marinović2
Estimated H-index: 2
(University of Rijeka)
+ 8 AuthorsFelix M. Wensveen18
Estimated H-index: 18
(University of Rijeka)
Summary Pro-inflammatory cytokines of a T helper-1-signature are known to promote insulin resistance (IR) in obesity, but the physiological role of this mechanism is unclear. It is also unknown whether and how viral infection induces loss of glycemic control in subjects at risk for developing diabetes mellitus type 2 (DM2). We have found in mice and humans that viral infection caused short-term systemic IR. Virally-induced interferon-γ (IFN-γ) directly targeted skeletal muscle to downregulate th...
5 Citations Source Cite
Published on Jan 1, 2018in Diabetes 7.27
Stephan Wueest15
Estimated H-index: 15
(Boston Children's Hospital),
Céline I. Laesser1
Estimated H-index: 1
(Boston Children's Hospital)
+ 6 AuthorsDaniel Konrad27
Estimated H-index: 27
(UZH: University of Zurich)
We recently showed that interleukin (IL)-6-type cytokine signaling in adipocytes induces free fatty acid release from visceral adipocytes, thereby promoting obesity-induced hepatic insulin resistance and steatosis. In addition, IL-6-type cytokines may increase the release of leptin from adipocytes and by those means induce glucagon-like peptide 1 (GLP-1) secretion. We thus hypothesized that IL-6-type cytokine signaling in adipocytes may regulate insulin secretion. To this end, mice with adipocyt...
7 Citations Source Cite
Published on Dec 1, 2017in Nature Communications 12.35
Flurin Item8
Estimated H-index: 8
(Boston Children's Hospital),
Stephan Wueest15
Estimated H-index: 15
(Boston Children's Hospital)
+ 14 AuthorsYoungsoo Kim45
Estimated H-index: 45
Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to hepatic fatty acid accumulation. Here, we show that the Fas cell surface death receptor (Fas/CD95/Apo-1) regulates hepatic mitochondrial metabolism. Hepatic Fas overexpression in chow-fed mice compromises fatty acid oxidation, mitochondrial respiration, and the abundance of mitoc...
5 Citations Source Cite
Published on Nov 1, 2017in Clinical Endocrinology 3.08
Stefan Fischli6
Estimated H-index: 6
,
Viktor von Wyl28
Estimated H-index: 28
(UZH: University of Zurich)
+ 9 AuthorsLuca Bernasconi5
Estimated H-index: 5
OBJECTIVES: Graves' hyperthyroidism (GH) interferes with iron metabolism and elevates ferritin. The precise mechanisms remain unclear. The influence of thyroid hormones on the synthesis/regulation of hepcidin, an important regulator of iron metabolism, remains uncharacterized. DESIGN: Prospective observational study. PATIENTS: We included patients (n = 31) with new-onset and untreated GH. MEASUREMENTS: Laboratory parameters indicative of iron metabolism (ferritin, transferrin, hepcidin), inflamm...
4 Citations Source Cite
Published on Nov 1, 2017in Immunity 19.73
Elise Dalmas7
Estimated H-index: 7
(University of Basel),
Frank M. Lehmann2
Estimated H-index: 2
(University of Basel)
+ 18 AuthorsDianne H. Dapito2
Estimated H-index: 2
(ETH Zurich)
Summary Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retin...
20 Citations Source Cite
Published on Mar 1, 2017in Nature Immunology 21.81
Erez Dror7
Estimated H-index: 7
,
Elise Dalmas7
Estimated H-index: 7
+ 17 AuthorsFriederike Schulze4
Estimated H-index: 4
The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other metabolic diseases is well documented. However, a possible physiological role for IL-1β in glucose metabolism has remained unexplored. Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous I...
56 Citations Source Cite
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