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Stephan Wueest
Boston Children's Hospital
39Publications
15H-index
1,251Citations
Publications 39
Newest
#1Mara A. Dedual (UZH: University of Zurich)
#2Stephan Wueest (Boston Children's Hospital)H-Index: 15
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 4
view all 4 authors...
Four days of high-fat diet (HFD) feeding are sufficient to induce glucose intolerance and hepatic steatosis in mice. While prolonged HFD-induced metabolic complications are partly mediated by incre...
#1Timothy S. Odermatt (UZH: University of Zurich)
#2Mara Dedual (UZH: University of Zurich)
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 27
view all 5 authors...
Repetitive physical activity is a well-established intervention to reduce obesity and to prevent weight regain. Besides increased energy expenditure, reduced caloric intake may contribute to exercise-induced weight loss in obesity. Using adipocyte-specific glycoprotein 130 knockout (gp130Δadipo) mice, we recently unravelled that obesity-induced interleukin-6 (IL-6) signalling in adipose tissue contributes to circulating levels of the two anorectic hormones leptin and insulin. Herein, we aimed to...
#1Tenagne D. Challa (Boston Children's Hospital)H-Index: 2
#2Stephan Wueest (Boston Children's Hospital)H-Index: 15
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 27
view all 9 authors...
#1Gerald GrandlH-Index: 4
#2Leon G. StraubH-Index: 5
Last.Christian WolfrumH-Index: 29
view all 7 authors...
KEY POINTS A ketogenic diet is known to lead to weight loss and is considered metabolically healthy; however there are conflicting reports on its effect on hepatic insulin sensitivity. KD fed animals appear metabolically healthy in the fasted state after 3 days of dietary challenge, whereas obesogenic high-fat diet (HFD) fed animals show elevated insulin levels. A glucose challenge reveals that both KD and HFD fed animals are glucose intolerant. Glucose intolerance correlates with increased lipi...
#1Stephan Wueest (Boston Children's Hospital)H-Index: 15
#2Daniel Konrad (UZH: University of Zurich)H-Index: 27
ABSTRACTHigh secretion of interleukin (IL)-6 from white adipose tissue may contribute to metabolic complications in obesity. We have recently shown that IL-6-type cytokine signaling in adipocytes is involved in the development of obesity-associated hepatic insulin resistance and steatosis. In addition, we revealed that adipocyte-specific IL-6 signaling ameliorates glucose metabolism in obesity via enhancing insulin secretion. Mechanistically, IL-6 induces the release of free fatty acid (FFA) and...
#1Marko Šestan (University of Rijeka)H-Index: 4
#2Sonja Marinović (University of Rijeka)H-Index: 2
Last.Felix M. Wensveen (University of Rijeka)H-Index: 18
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Summary Pro-inflammatory cytokines of a T helper-1-signature are known to promote insulin resistance (IR) in obesity, but the physiological role of this mechanism is unclear. It is also unknown whether and how viral infection induces loss of glycemic control in subjects at risk for developing diabetes mellitus type 2 (DM2). We have found in mice and humans that viral infection caused short-term systemic IR. Virally-induced interferon-γ (IFN-γ) directly targeted skeletal muscle to downregulate th...
#1Stephan Wueest (Boston Children's Hospital)H-Index: 15
#2Céline I. Laesser (Boston Children's Hospital)H-Index: 1
Last.Daniel Konrad (UZH: University of Zurich)H-Index: 27
view all 9 authors...
We recently showed that interleukin (IL)-6-type cytokine signaling in adipocytes induces free fatty acid release from visceral adipocytes, thereby promoting obesity-induced hepatic insulin resistance and steatosis. In addition, IL-6-type cytokines may increase the release of leptin from adipocytes and by those means induce glucagon-like peptide 1 (GLP-1) secretion. We thus hypothesized that IL-6-type cytokine signaling in adipocytes may regulate insulin secretion. To this end, mice with adipocyt...
#1Flurin Item (Boston Children's Hospital)H-Index: 8
#2Stephan Wueest (Boston Children's Hospital)H-Index: 15
Last.Youngsoo KimH-Index: 45
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Nonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to hepatic fatty acid accumulation. Here, we show that the Fas cell surface death receptor (Fas/CD95/Apo-1) regulates hepatic mitochondrial metabolism. Hepatic Fas overexpression in chow-fed mice compromises fatty acid oxidation, mitochondrial respiration, and the abundance of mitoc...
#1Stefan FischliH-Index: 6
#2Viktor von Wyl (UZH: University of Zurich)H-Index: 28
Last.Luca BernasconiH-Index: 5
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OBJECTIVES: Graves' hyperthyroidism (GH) interferes with iron metabolism and elevates ferritin. The precise mechanisms remain unclear. The influence of thyroid hormones on the synthesis/regulation of hepcidin, an important regulator of iron metabolism, remains uncharacterized. DESIGN: Prospective observational study. PATIENTS: We included patients (n = 31) with new-onset and untreated GH. MEASUREMENTS: Laboratory parameters indicative of iron metabolism (ferritin, transferrin, hepcidin), inflamm...
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