Fate and characterization of circulating tumor cells in a NOD/SCID mouse model of human hepatocellular carcinoma
Abstract
There is much debate about the way in which epithelial tumors metastasize. It has been proposed that the bone marrow (BM) acts as a tumor cell reservoir. We injected human hepatocellular carcinoma (HCC) cells (Mahlavu cell line) into the livers, circulation or BM of NOD/SCID mice and circulating tumor cells were quantified. When injected under the Glisson capsule, a primary tumor developed and continuously yielded circulating tumor cells. Liver...
Paper Details
Title
Fate and characterization of circulating tumor cells in a NOD/SCID mouse model of human hepatocellular carcinoma
Published Date
Feb 20, 2006
Journal
Volume
25
Issue
29
Pages
4067 - 4075
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