Franck Chiappini
University of Paris
Publications 15
#1Franck Chiappini (French Institute of Health and Medical Research)H-Index: 5
Liver cancer is the fifth most common cancer in men and the seventh in women. During the past 20 years, the incidence of HCC has tripled while the 5-year survival rate has remained below 12%. The presence of circulating tumor cells (CTC) reflects the aggressiveness nature of a tumor. Many attempts have been made to develop assays that reliably detect and enumerate the CTC during the development of the HCC. In this case, the challenges are (1) there are few markers specific to the HCC (tumor cell...
#1Natalia OlayaH-Index: 3
#2Franck ChiappiniH-Index: 10
Hepatocellular carcinoma (HCC) is responsible for significant morbidity and mortality in cirrhosis and also accounts for between 85% and 90% of primary liver cancer (Caldwell & Park 2009; Hussain & El-Serag 2009; Tandon & Garcia-Tsao 2009). Most of HCC in the world occur in the setting of cirrhosis and over half-million of people develop liver cancer every year and an almost equal number die of it (Caldwell & Park 2009; Hussain & El-Serag 2009). Liver cancer prognosis is determined by factors re...
#1Franck ChiappiniH-Index: 10
#2Elina TeicherH-Index: 17
Last.Antoinette LemoineH-Index: 38
view all 6 authors...
Nucleoside Reverse Transcriptase Inhibitors (NRTIs) used for the treatment of HIV-1 inhibit the replication of mitochondrial DNA (mtDNA), which may contribute to severe mitochondrial toxicity including lipodystrophy, through the inhibition of polymerase gamma (POLG). Polymorphisms of POLG could explain the variation in mitochondrial toxicity in HIV-1-infected patients. We explored the relationship between selected polymorphisms of POLG and lipodystrophy related to NRTIs. We studied single nucleo...
#1Olivier Scatton (University of Paris)H-Index: 25
#2Franck Chiappini (University of Paris)H-Index: 10
Last.Antoinette Lemoine (University of Paris)H-Index: 38
view all 8 authors...
Background To establish a new experimental model of human hepatocellular carcinoma by orthotopic implantation of tumoral cells with its subsequent removal, to generate and modulate circulating tumoral cells. Materials and methods Three human hepatoma cell lines (HepG2, PLC/PRF, and Mahlavu) were orthotopically implanted under the Glisson's capsule of the left lateral lobe of the liver in a total of 56 non-obese diabetic/severe combined immunodeficiency mice. Tumor removal was performed 30 d afte...
La transplantation hepatique (TH) est le traitement de la cirrhose decompensee obeissant a des indications strictes. Le patient infecte par le VIH etait exclu par principe de la transplantation. Les progres de la prise en charge remettent en cause cet algorithme. Objectif Decrire les aspects cliniques, biologiques et immunovirologiques d’une cohorte de transplantes hepatiques infectes par le VIH. Methodes De decembre 1999 a fevrier 2008, 82 patients ont ete transplantes. L’inscription sur la lis...
#1Olivier Scatton (University of Paris)H-Index: 25
#2Franck Chiappini (University of Paris)H-Index: 10
Last.Uzan G (University of Paris)H-Index: 1
view all 11 authors...
There is much debate about the way in which epithelial tumors metastasize. It has been proposed that the bone marrow (BM) acts as a tumor cell reservoir. We injected human hepatocellular carcinoma (HCC) cells (Mahlavu cell line) into the livers, circulation or BM of NOD/SCID mice and circulating tumor cells were quantified. When injected under the Glisson capsule, a primary tumor developed and continuously yielded circulating tumor cells. Liver tumor removal led to a very low level of Mahlavu ce...
#1Franck Chiappini (Pfizer)H-Index: 10
#2Alain Barrier (UPMC: Pierre-and-Marie-Curie University)H-Index: 15
Last.Brigitte Debuire (University of Paris)H-Index: 22
view all 12 authors...
Exploration of global gene expression in human liver steatosis by high-density oligonucleotide microarray
#1Alain Barrier (UPMC: Pierre-and-Marie-Curie University)H-Index: 15
#2Pierre-Yves Boëlle (UPMC: Pierre-and-Marie-Curie University)H-Index: 47
Last.Antoine Flahault (UPMC: Pierre-and-Marie-Curie University)H-Index: 54
view all 11 authors...
PURPOSE:This study assessed the possibility to build a prognosis predictor, based on microarray gene expression measures, in Stage II and III colon cancer patients.METHODS:Tumor and nonneoplastic mucosa mRNA samples from 12 colon cancer patients were profiled using theAffymetrix HGU133AGeneChip. Six
#1Alain Barrier (University of California, Berkeley)H-Index: 15
#2Natalia Olaya (University of Paris-Sud)H-Index: 3
Last.Brigitte Debuire (University of Paris-Sud)H-Index: 22
view all 12 authors...
Ischemia triggers an inflammatory response that precipitates cell death during reperfusion. Several studies have shown that tissues are protected by ischemic preconditioning (IP) consisting of 10 min of ischemia followed by 10 min of reperfusion just before ischemia. The molecular basis of this protective effect is poorly understood. We used cDNA arrays (20K) to compare global gene expression in liver biopsies from living human liver donors who underwent IP (n=7) or not (n=7) just before liver d...
#1Alain Barrier (UPMC: Pierre-and-Marie-Curie University)H-Index: 15
#2Antoinette Lemoine (University of Paris)H-Index: 38
Last.Michel Huguier (UPMC: Pierre-and-Marie-Curie University)H-Index: 23
view all 15 authors...
This study assessed the possibility to build a prognosis predictor, based on microarray gene expression measures, in stage II and III colon cancer patients. Tumour (T) and non-neoplastic mucosa (NM) mRNA samples from 18 patients (nine with a recurrence, nine with no recurrence) were profiled using the Affymetrix HGU133A GeneChip. The k-nearest neighbour method was used for prognosis prediction using T and NM gene expression measures. Six-fold cross-validation was applied to select the number of ...