Franck Chiappini
University of Paris-Sud
CancerHepatocellular carcinomaCancer researchMedicineBiology
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Publications 23
#1Audrey CoillyH-Index: 19
#2Christophe Desterke (French Institute of Health and Medical Research)H-Index: 18
Last. Franck ChiappiniH-Index: 10
view all 5 authors...
Nonalcoholic fatty liver (NAFLD) may progress to nonalcoholic steatohepatitis (NASH) and ultimately to cirrhosis and hepatocellular carcinoma (HCC). Prognostic markers for these conditions are poorly defined. The aim of this study was to identify predictive gene markers for the transition from NAFL to NASH and then to poorer conditions. Gene expression omnibus datasets associated with a prediction analysis algorithm were used to create a matrix composed of control subject (n = 52), healthy obese...
2 CitationsSource
Nonalcoholic steatohepatitis (NASH) is becoming a public health problem worldwide. While the number of research studies on NASH progression rises every year, sometime their findings are controversial. To identify the most important and commonly described findings related to NASH progression, we used an original bioinformatics, integrative, text-mining approach that combines PubMed database querying and available gene expression omnibus dataset. We have identified a signature of 25 genes that are...
2 CitationsSource
#1Marion Darnaud (French Institute of Health and Medical Research)H-Index: 4
#2Alexandre Dos Santos (French Institute of Health and Medical Research)H-Index: 11
Last. Jamila Faivre (French Institute of Health and Medical Research)H-Index: 15
view all 21 authors...
Background & Aims Paneth cell dysfunction causes deficiencies in intestinal C-type lectins and antimicrobial peptides, which leads to dysbiosis of the intestinal microbiota, alters the mucosal barrier, and promotes development of inflammatory bowel diseases. We investigated whether transgenic (TG) expression of the human regenerating family member 3 alpha gene ( REG3A ) alters the fecal microbiota and affects development of colitis in mice. Methods We performed studies with C57BL/6 mice that exp...
17 CitationsSource
#1Franck ChiappiniH-Index: 6
#2Audrey CoillyH-Index: 19
Last. François Le NaourH-Index: 28
view all 13 authors...
Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients
22 CitationsSource
#1Chengyuan Peng (French Institute of Health and Medical Research)H-Index: 3
#2Slávka Kaščáková (French Institute of Health and Medical Research)H-Index: 6
Last. François Le Naour (French Institute of Health and Medical Research)H-Index: 28
view all 10 authors...
Background Hepatocarcinogenesis is a multistep process characterized in patients with chronic liver diseases by a spectrum of hepatic nodules that mark the progression from regenerative nodules to dysplastic lesions followed by hepatocellular carcinoma (HCC). The differential diagnosis between precancerous dysplastic nodules and early HCC still represents a challenge for both radiologists and pathologists. We addressed the potential of Fourier transform-infrared (FTIR) microspectroscopy for grad...
7 CitationsSource
#1Franck ChiappiniH-Index: 6
#2Christophe DesterkeH-Index: 18
Last. François Le NaourH-Index: 28
view all 5 authors...
Nonalcoholic fatty liver (NAFL) is a precursor of nonalcoholic steatohepatitis (NASH), a condition that may progress to cirrhosis and hepatocellular carcinoma. Markers for diagnosis of NASH are still lacking. We have investigated lipid markers using mouse models that developed NAFL when fed with high fat diet (HFD) or NASH when fed using methionine choline deficient diet (MCDD). We have performed a comprehensive lipidomic analysis on liver tissues as well as on sera from mice fed HFD (n = 5), MC...
11 CitationsSource
#1Audrey CoillyH-Index: 19
#2Franck ChiappiniH-Index: 6
#1Chengyuan Peng (University of Paris-Sud)H-Index: 3
#2Franck Chiappini (University of Paris-Sud)H-Index: 6
Last. François Le Naour (University of Paris-Sud)H-Index: 28
view all 9 authors...
Non-alcoholic fatty liver disease (NAFLD) is a frequent lesion associated with obesity, diabetes and the metabolic syndrome. The hallmark feature of fatty liver disease is steatosis, which is the intra-cellular accumulation of lipids resulting in the formation of vesicles in hepatocytes. Steatosis is a precursor of steatohepatitis, a condition that may progress to hepatic fibrosis, cirrhosis and primary liver cancer. We addressed the potential of Fourier transform-infrared (FTIR) microspectrosco...
10 CitationsSource
#2Frédéric JammeH-Index: 19
Last. Matthieu RéfrégiersH-Index: 23
view all 6 authors...
Fibrillar distribution in the rat tail tendon and mice liver can be measured using optical methods. Two-photon excitation provides easy assessment of fibrotic collagen types I and II. Single photon deep ultraviolet (DUV) excitation imaging highlights all collagen types without discrimination. Their combination on the same tissue area provides a better overview of collagens in fibrillar diseases.
#1François Le NaourH-Index: 28
#2Christophe SandtH-Index: 17
Last. Paul DumasH-Index: 37
view all 8 authors...
11ABSTRACT:Liver is subject to various chronic pathologies, progressively leading to 12cirrhosis, which is associated with an increased risk of hepatocellular carcinoma. There is an 13urgent need for diagnostic and prognostic markers of chronic liver diseases and liver cancer. 14Spectroscopy-based approaches can provide an overview of the chemical composition of a 15tissue sample offering the possibility of investigating in depth the subtle chemical changes 16associated with pathological states....
17 CitationsSource