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#1Qingzu Gao (Southern Medical University)H-Index: 2
#2Rui Zhou (Southern Medical University)H-Index: 4
Last. Liang Zhao (Southern Medical University)H-Index: 12
view all 9 authors...
Long noncoding RNAs (lncRNAs) have been shown to play crucial roles in cancer long noncoding RNAs (lncRNAs) have been known to play crucial roles in cancer development and progression by regulating chromatin dynamics and gene expression. However, only a few lncRNAs with annotated functions in the progression of colorectal cancer (CRC) have been identified to date. In the present study, the expression of lncCMPK2 was upregulated in CRC tissues and positively correlated with clinical stages and ly...
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#1Janna Wenzel (University of Freiburg)
#2Katja Rose (University of Freiburg)H-Index: 2
Last. Andreas Hecht (University of Freiburg)H-Index: 28
view all 9 authors...
The transcription factor TCF7L2 is indispensable for intestinal tissue homeostasis where it transmits mitogenic Wnt/β-Catenin signals in stem and progenitor cells, from which intestinal tumors arise. Yet, TCF7L2 belongs to the most frequently mutated genes in colorectal cancer (CRC), and tumor-suppressive functions of TCF7L2 were proposed. This apparent paradox warrants to clarify the role of TCF7L2 in colorectal carcinogenesis. Here, we investigated TCF7L2 dependence/independence of CRC cells a...
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#1Mark Williams (MSU: Michigan State University)H-Index: 3
#2Xinhui Liu (Southern Medical University)
Last. Rongcheng Luo (Southern Medical University)H-Index: 4
view all 12 authors...
Prevention and treatment options for hepatocellular carcinoma (HCC) are presently limited, underscoring the necessity for further elucidating molecular mechanisms underlying HCC development and identifying new prevention and therapeutic targets. Here, we demonstrate a unique protumorigenic niche in the livers of Ncoa5+/− mouse model of HCC, which is characterized by altered expression of a subset of genes including p21WAF1/CIP1 and proinflammatory cytokine genes, increased putative hepatic proge...
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#1Samuel Hsien Lai (WMU: Western Michigan University)
#2Guston Zervoudakis (WMU: Western Michigan University)
Last. Kelly Quesnelle (WMU: Western Michigan University)H-Index: 8
view all 5 authors...
Cyclic nucleotide phosphodiesterases (PDE) break down cyclic nucleotides such as cAMP and cGMP, reducing the signaling of these important intracellular second messengers. Several unique families of phosphodiesterases exist, and certain families are clinically important modulators of vasodilation. In the current work, we have summarized the body of literature that describes an emerging role for the PDE4 subfamily of phosphodiesterases in malignancy. We have systematically investigated PDE4A, PDE4...
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#1Muskan Floren (UNM: University of New Mexico)H-Index: 1
#2Sebastian Restrepo Cruz (UNM: University of New Mexico)H-Index: 1
Last. Jennifer M. Gillette (UNM: University of New Mexico)H-Index: 13
view all 6 authors...
A principal challenge in treating acute myeloid leukemia (AML) is chemotherapy refractory disease. As such, there remains a critical need to identify key regulators of chemotherapy resistance in AML. In this study, we demonstrate that the membrane scaffold, CD82, contributes to the chemoresistant phenotype of AML. Using an RNA-seq approach, we identified the increased expression of the tetraspanin family member, CD82, in response to the chemotherapeutic, daunorubicin. Analysis of the TARGET and ...
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#1Wenjiao Li (A&M: Texas A&M University)H-Index: 7
#2Yuan Dai (A&M: Texas A&M University)H-Index: 1
Last. Leyuan Liu (A&M: Texas A&M University)H-Index: 21
view all 10 authors...
Mutants in the gene encoding mitochondrion-associated protein LRPPRC were found to be associated with French Canadian Type Leigh syndrome, a human disorder characterized with neurodegeneration and cytochrome c oxidase deficiency. LRPPRC interacts with one of microtubule-associated protein family MAP1S that promotes autophagy initiation and maturation to suppress genomic instability and tumorigenesis. Previously, although various studies have attributed LRPPRC nuclear acid-associated functions, w...
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#1Norihito ShibataH-Index: 11
#2Nobumichi OhokaH-Index: 18
Last. Mikihiko NaitoH-Index: 44
view all 8 authors...
Fusion genes resulting from chromosomal rearrangements are frequently found in a variety of cancer cells. Some of these are known to be driver oncogenes, such as BCR-ABL in chronic myelogenous leukemia (CML). The products of such fusion genes are abnormal proteins that are ordinarily degraded in cells by a mechanism known as protein quality control. This suggests that the degradation of BCR-ABL protein is suppressed in CML cells to ensure their proliferative activity. Here, we show that ubiquiti...
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#1Cathinka Boedicker (DKFZ: German Cancer Research Center)H-Index: 5
#2Michelle Hussong (Epigenomics AG)H-Index: 4
Last. Simone Fulda (DKFZ: German Cancer Research Center)H-Index: 73
view all 10 authors...
Remodeling transcription by targeting bromodomain and extraterminal (BET) proteins has emerged as promising anticancer strategy. Here, we identify a novel synergistic interaction of the BET inhibitor JQ1 with the PI3Kα-specific inhibitor BYL719 to trigger mitochondrial apoptosis and to suppress tumor growth in models of rhabdomyosarcoma (RMS). RNA-Seq revealed that JQ1/BYL719 co-treatment shifts the overall balance of BCL-2 family gene expression towards apoptosis and upregulates expression of B...
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#1Hanyu Rao (SJTU: Shanghai Jiao Tong University)
#2Xuefeng Li (University of South China)
Last. Wei-Qiang Gao (SJTU: Shanghai Jiao Tong University)H-Index: 40
view all 8 authors...
Clear cell renal cell carcinoma (ccRCC) is one of the most common and lethal human urological malignancies in the world. One of the pathological drivers for ccRCC is the Ras family of small GTPases that function as “molecular switches” in many diseases including ccRCC. Among the GTPases in the Di-Ras family, DIRAS2 gene encodes a GTPase that shares 60% homology to Ras and Rap. Yet little is known about the biological function(s) of Di-Ras2 or how its activities are regulated. In this study, we f...
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#1Marie-Emilie Francart (University of Liège)H-Index: 3
#2Aline Vanwynsberghe (University of Liège)H-Index: 1
Last. Ingrid Struman (University of Liège)H-Index: 27
view all 12 authors...
Epithelial–mesenchymal transitions (EMTs) are high-profile in the field of circulating tumor cells (CTCs). EMT-shifted CTCs are considered to encompass pre-metastatic subpopulations though underlying molecular mechanisms remain elusive. Our previous work identified tissue factor (TF) as an EMT-induced gene providing tumor cells with coagulant properties and supporting metastatic colonization by CTCs. We here report that vimentin, the type III intermediate filament considered a canonical EMT mark...
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Cancer
Molecular biology
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