Papers 19835
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#1Mengyao Qian (WMU: Wenzhou Medical College)
#2Jingwen Geng (WMU: Wenzhou Medical College)H-Index: 1
Last.Jianmin Wu (WMU: Wenzhou Medical College)
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Cancer immune surveillance is an important host protection process that inhibits carcinogenesis and maintains cellular homeostasis. The major histocompatibility complex class I-related molecules A and B (MICA and MICB) are NKG2D ligands that play important roles in tumor immune surveillance. In the present study, by a combined bioinformatics prediction and experimental approach, we identify BCL11B 3′-UTR as a putative MICA and MICB ceRNA. We demonstrate in several human cell lines of different o...
#1Qun Zhang (Nanjing Medical University)H-Index: 4
#2Hang Fan (NU: Nanjing University)H-Index: 3
Last.Yong Song (NU: Nanjing University)H-Index: 27
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WNT5B glycoprotein belongs to the Wnt protein family. Limited investigations revealed a possible role of WNT5B in malignancies, such as triple-negative breast cancer and oral squamous cell carcinoma. However, whether WNT5B contributes to the progression of lung adenocarcinoma (LAD) remains unclear. Here, we initially determine that WNT5B is highly expressed in LAD and is positively correlated with lymph node metastasis and TNM stage. Consistently, clinical analysis reveals WNT5B as an independen...
#1Ayse Nihan Kilinc (University of Basel)
#2Nami Sugiyama (University of Basel)H-Index: 1
Last.Gerhard Christofori (University of Basel)H-Index: 59
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An epithelial–mesenchymal transition (EMT) represents a basic morphogenetic process of high cell plasticity underlying embryogenesis, wound healing, cancer metastasis and drug resistance. It involves a profound transcriptional and epigenetic reprogramming of cells. A critical role of epigenetic modifiers and their specific chromatin modifications has been demonstrated during EMT. However, it has remained elusive whether epigenetic control differs between the dynamic cell state transitions of rev...
#1Guolong Xu (Nanjing Medical University)H-Index: 2
#2Dongju Feng (Nanjing Medical University)
Last.Yun Chen (Nanjing Medical University)H-Index: 10
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Recently, patients with advanced cancers have been benefited greatly from immune checkpoint blockade immunotherapy. However, immune checkpoint blockade is still suboptimal in HCC treatment and more immune modifications are needed to achieve an efficient therapeutic goal. Here, we investigated the combined administration of a Listeria-based HCC vaccine, Lmdd-MPFG, and the anti-PD-1 immune checkpoint blockade antibody. We found that Lmdd-MPFG promoted the expression of PD-L1 in HCC cells but resen...
#1Sospeter Ngoci Njeru (Paul Ehrlich Institute)H-Index: 1
#2Johann M. Kraus (University of Ulm)H-Index: 18
Last.K. Lenhard Rudolph (NIH: National Institutes of Health)H-Index: 35
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Aneuploidy can instigate tumorigenesis. However, mutations in genes that control chromosome segregation are rare in human tumors as these mutations reduce cell fitness. Screening experiments indicate that the knockdown of multiple classes of genes that are not directly involved in chromosome segregation can lead to aneuploidy induction. The possible contribution of these genes to cancer formation remains yet to be defined. Here we identified gene knockdowns that lead to an increase in aneuploidy...
#1Nicholas J. H. Warren (Dartmouth College)H-Index: 1
#2Alan Eastman (Dartmouth College)H-Index: 45
Inhibition of the DNA damage response is an emerging strategy to treat cancer. Understanding how DNA damage response inhibitors cause cytotoxicity in cancer cells is crucial to their further clinical development. This review focuses on three different mechanisms of cell killing by checkpoint kinase I inhibitors (CHK1i). DNA damage induced by chemotherapy drugs, such as topoisomerase I inhibitors, results in S and G2 phase arrest. Addition of CHK1i promotes cell cycle progression before repair is...
#1Ryan T. Nitta (Stanford University)H-Index: 10
#2Sara Bolin (Stanford University)H-Index: 7
Last.Gordon Li (Stanford University)H-Index: 24
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The original version of this Article contained an error in the spelling of the author David Solow-Cordero, which was incorrectly given as David Solow-Codero. This has now been corrected in both the PDF and HTML versions of the Article.
#1Quan Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 7
#2Xiongyan Wu (SJTU: Shanghai Jiao Tong University)H-Index: 8
Last.Liping Su (SJTU: Shanghai Jiao Tong University)H-Index: 24
view all 12 authors...
Gastric cancer (GC) is characterized by extensive local invasion, distant metastasis and poor prognosis. In most cases, GC progression is associated with aberrant expression of cytokines or activation of signaling cascades mediated by tumor–stroma interactions. However, the mechanisms by which these interactions contribute to GC progression are poorly understood. In this study, we find that IL-33 and its receptor ST2L are upregulated in the human GC and served as prognostic markers for poor surv...
#1Chengjian Guan (Capital Medical University)H-Index: 1
#2Lin He (PKU: Peking University)H-Index: 27
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Discerning oncogenic drivers from passengers remain a major effort in understanding of the essence of the initiation and development of hepatocellular carcinoma (HCC), which is the most common primary liver malignancy and the third leading cause of cancer mortality worldwide. Here we report that ZNF774, a novel zinc-finger protein, inhibits the proliferation and invasion of HCC cells. Molecular characterization of this protein indicated that ZNF774 acts as a transcription repressor, and interrog...
#1Sean A. Misek (MSU: Michigan State University)H-Index: 2
#2Kathryn M. Appleton (MSU: Michigan State University)H-Index: 1
Last.Richard R. Neubig (MSU: Michigan State University)H-Index: 57
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Over half of cutaneous melanoma tumors have BRAFV600E/K mutations. Acquired resistance to BRAF inhibitors (BRAFi) remains a major hurdle in attaining durable therapeutic responses. In this study we demonstrate that ~50–60% of melanoma cell lines with vemurafenib resistance acquired in vitro show activation of RhoA family GTPases. In BRAFi-resistant melanoma cell lines and tumors, activation of RhoA is correlated with decreased expression of melanocyte lineage genes. Using a machine learning appr...
Top fields of study
Molecular biology
Cancer research