Papers 19940
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#1Chengjian Guan (Capital Medical University)H-Index: 1
#2Lin He (PKU: Peking University)H-Index: 27
view all 6 authors...
#1Takuma Hayashi (Shinshu University)H-Index: 7
#2Kenji Sano (Shinshu University)H-Index: 22
Last.Ikuo KonishiH-Index: 50
view all 5 authors...
#1Po-Chu Lee (NTU: National Taiwan University)H-Index: 9
#2Syue-Ting Chen (NTU: National Taiwan University)H-Index: 3
Last.Po-Huang Lee (NTU: National Taiwan University)H-Index: 56
view all 11 authors...
C1GALT1 controls the crucial step of GalNAc-type O-glycosylation and is associated with both physiologic and pathologic conditions, including cancers. EPH receptors comprise the largest family of receptor tyrosine kinases (RTKs) and modulate a diverse range of developmental processes and human diseases. However, the role of C1GALT1 in the signaling of EPH receptors remains largely overlooked. Here, we showed that C1GALT1 high expression in gastric adenocarcinomas correlated with adverse clinicop...
#1Miao Qi (Ministry of Education)H-Index: 2
#2Dan Dai (Ministry of Education)
Last.Yaoyao Song (Ministry of Education)
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Mitochondrial fusion and fission dynamics fine-tune cellular calcium homeostasis, ATP production capacity and ROS production and play important roles in cell proliferation and migration. Dysregulated mitochondrial dynamics is closely related to tumor development, but the mechanism of mitochondrial dynamics dysregulation and its role in the development of lung cancer remains unclear. Here, we demonstrate that the DNA sensor protein absent in melanoma 2 (AIM2) is highly expressed in non-small cell...
#1Jing He (Fudan University)H-Index: 1
#2Mingxia Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last.Jian Zhou (Fudan University)H-Index: 1
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Thyroid cancer is the fastest growing cancer among all solid tumors in recent decades. Papillary thyroid carcinoma (PTC) is the most predominant type of thyroid cancer. Around 30% of PTC patients with distant metastases and local invasion receive poor prognosis. Thus, the identification of new druggable biological targets is of great importance. Accumulating evidence indicates that solute carrier family numbers have emerged as obligate effectors during the progression of multiple malignancies. H...
#1Ran Ran (University of Manchester)
#2Hannah Harrison (University of Manchester)H-Index: 11
Last.Karen Blyth (Glas.: University of Glasgow)H-Index: 34
view all 12 authors...
Epithelial to mesenchymal transition (EMT) is a dynamic process that drives cancer cell plasticity and is thought to play a major role in metastasis. Here we show, using MDA-MB-231 cells as a model, that the plasticity of at least some metastatic breast cancer cells is dependent on the transcriptional co-regulator CBFβ. We demonstrate that CBFβ is essential to maintain the mesenchymal phenotype of triple-negative breast cancer cells and that CBFβ-depleted cells undergo a mesenchymal to epithelia...
#1Yumei Li (FZU: Fuzhou University)
#2Yu Zhou (FZU: Fuzhou University)H-Index: 1
Last.Vladimir L. Katanaev (Minjiang University)H-Index: 23
view all 11 authors...
The key molecules and underlying mechanisms of melanoma metastasis remain poorly understood. Using isobaric tag for relative and absolute quantitation (iTRAQ) proteomic screening, probing of patients’ samples, functional verification, and mechanistic validation, we identified the important role of the WD repeat-containing protein 74 (WDR74) in melanoma progression and metastasis. Through gain- and loss-of-function approaches, WDR74 was found to promote cell proliferation, apoptosis resistance, a...
#1Shaorong Yu (Nanjing Medical University)H-Index: 8
#2Huan-huan Sha (Nanjing Medical University)H-Index: 5
Last.Jifeng Feng (Nanjing Medical University)H-Index: 23
view all 7 authors...
EGFR-mutant lung cancer (LC) patients display a poor response to PD-1/PD-L1 blockade. In the absence of independent genetic validation, whether EGFR mutation distorts host antitumor immunity is unknown. Here, we showed that in the clinic, LC with the E746-A750 deletion mutation (EGFR-19del) displayed a temporal association with the loss of intratumoral CD8+ T cells. In a xenograft model, EGFR-19del-expressing Lewis lung cancer (LLC) tumors had a low T cell density at the early stage of tumor dev...
#1Thomas Naert (UGent: Ghent University)H-Index: 4
#2Dionysia Dimitrakopoulou (UGent: Ghent University)H-Index: 2
Last.Christian Vanhove (Ghent University Hospital)H-Index: 27
view all 13 authors...
Alterations of the retinoblastoma and/or the p53 signaling network are associated with specific cancers such as high-grade astrocytoma/glioblastoma, small-cell lung cancer (SCLC), choroid plexus tumors, and small-cell pancreatic neuroendocrine carcinoma (SC-PaNEC). However, the intricate functional redundancy between RB1 and the related pocket proteins RBL1/p107 and RBL2/p130 in suppressing tumorigenesis remains poorly understood. Here we performed lineage-restricted parallel inactivation of rb1...
Last.Françoise Dantzer (CNRS: Centre national de la recherche scientifique)H-Index: 32
view all 14 authors...
Poly(ADP-ribose)-polymerase (PARP)-1 and PARP-2 play an essential role in the DNA damage response. Based on this effect of PARP in the tumor cell itself, PARP inhibitors have emerged as new therapeutic tools both approved and in clinical trials. However, the interactome of multiple other cell types, particularly T cells, within the tumor microenvironment are known to either favor or limit tumorigenesis. Here, we bypassed the embryonic lethality of dually PARP-1/PARP-2-deficient mice by using a P...
Top fields of study
Molecular biology
Cancer research