Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats

The effectiveness of an oral administration of insulin microspheres (IMS) containing a protease inhibitor was evaluated in normal and diabetic rats. The dosage form is based on the incorporation of insulin with protease inhibitor into polyacrylic polymer (Eudragit L100). These preparations were administered orally with a 20 U/kg insulin dose by force-feeding to rats. Insulin absorption was evaluated by its hypoglycemic effect. IMS without...