Mariko Morishita
Hoshi University
ChemistryInsulinBiochemistryDosage formPharmacology
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Publications 84
#1Mariko Morishita (Hoshi University)H-Index: 38
#2El-Sayed Khafagy (Hoshi University)H-Index: 12
Last. Nicholas A. PeppasH-Index: 88
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1 Citations
#1Mariko MorishitaH-Index: 38
#2Kinam ParkH-Index: 77
#1James SwarbrickH-Index: 1
11 CitationsSource
#1Mariko MorishitaH-Index: 38
#2Kinam ParkH-Index: 77
Biodrug delivery systems : , Biodrug delivery systems : , کتابخانه دیجیتال جندی شاپور اهواز
We investigated the mechanisms of ritonavir-mediated enhancement effect on the pharmacokinetics of saquinavir using in vivo probes for CYP3A4 (midazolam), p-glycoprotein (fexofenadine), and OATP1B1 (pravastatin) following oral micro/small dosing. A cocktail of the drugs (2 mg of saquinavir, 100 µg of each probe) was administered to eight healthy volunteers (phase 1), and then coadministered with 20 mg (phase 2) and 100 mg (phase 3) of ritonavir. Plasma concentrations of the drugs were measured b...
20 CitationsSource
#1Atsuko Tomaru (Hoshi University)H-Index: 4
#2Nozomi Morimoto (Hoshi University)H-Index: 2
Last. Yuichi Sugiyama (UTokyo: University of Tokyo)H-Index: 103
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Summary: Oral sulfasalazine (SASP) is now used clinically as a probe substrate of a breast cancer resistance protein (BCRP) activity; however the intestinal absorption characteristics of SASP are not well understood. The purpose of this study was to clarify the characteristics of SASP transport in the mouse intestine. The everted ileum was incubated with SASP in the absence or presence of the Bcrp inhibitor Ko134. The steady- state intestinal absorptive clearance was 0.14μL/min/cm in the absence...
9 CitationsSource
#1Hiroyuki Kusuhara (UTokyo: University of Tokyo)H-Index: 67
#2Hidetoshi FuruieH-Index: 1
Last. Yuichi Sugiyama (UTokyo: University of Tokyo)H-Index: 103
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BACKGROUND AND PURPOSE An ATP-binding cassette (ABC) transporter, breast cancer resistance protein (BCRP)/ABCG2, limits oral bioavailability of sulphasalazine. Here we examined the effect of curcumin, the principal curcuminoid of turmeric, on oral bioavailability of microdoses and therapeutic doses of sulphasalazine in humans. EXPERIMENTAL APPROACH Effects of curcumin were measured on the ATP-dependent sulphasalazine uptake by hBCRP-expressing membrane vesicles and on oral bioavailability of sul...
81 CitationsSource
10 CitationsSource
#1El-Sayed Khafagy (Suez Canal University)H-Index: 12
#2Mariko Morishita (Hoshi University)H-Index: 38
During the past few decades, the novel biotherapeutic agents such as peptides and proteins have been contributed to the treatment of several diseases. However, their oral absorption is significantly limited due to their poor delivery through the intestinal mucosa. Therefore, the feasible approaches are needed for improving the oral bioavailability of biodrugs. Recently, cell-penetrating peptides (CPPs) such as HIV-1 Tat, penetratin and oligoarginine are considered as a useful tool for the intrac...
107 CitationsSource
#1Kok Hoong Leong (UM: University of Malaya)H-Index: 10
#2Lip Yong Chung (UM: University of Malaya)H-Index: 19
Last. Kozo Takayama (Hoshi University)H-Index: 47
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a b s t r a c t We hypothesized that pH-responsive carboxymethylated kappa-carrageenan microparticles could pro- tect entrapped oral insulin from acidic and proteolytic degradation in the gastrointestinal tract. Therefore, the objectives of this study were to prepare and characterize insulin entrapped in lectin-functionalized carboxymethylated kappa-carrageenan microparticles and to evaluate their therapeutic efficacy in vitro and in vivo. The encapsulation of insulin was performed using an ioni...
37 CitationsSource