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International Journal of Pharmaceutics
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#1Yi ChenH-Index: 1
#2Qianming Du (Nanjing Medical University)H-Index: 4
Last. Jianqing PengH-Index: 1
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Abstract High metastasis is responsible for the failure in the treatment of melanoma. Chemoimmunotherapy has shown conspicuous inhibition effects not only on the growth of tumor in situ, but also on the metastasis to distant organs. Given that the indoleamine-2,3 dioxygenase (IDO) overexpressed in the microenvironment of tumor leads to the immune escape, the combination of chemotherapeutic drug and IDO inhibitor might be a promising chemoimmunotherapy. Besides, the hematogenous metastasis mediat...
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The world is facing a medical crisis amid the CoViD-19 pandemic and the role of adequate hygiene and hand sanitisers is inevitable in controlling the spread of infection in public places and healthcare institutions. There has been a great surge in demand for hand sanitisation products leading to shortages in their supply. A consequent increase of substandard products in the market has raised safety concerns. This article, therefore, presents a critical review of hand sanitation approaches and pr...
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#1Sherif I. Hamdallah (UEA: University of East Anglia)
#2Randa Zoqlam (UEA: University of East Anglia)
Last. Sheng Qi (UEA: University of East Anglia)H-Index: 18
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Abstract Using micro-sized channels to manipulate fluids is the essence of microfluidics which has wide applications from analytical chemistry to material science and cell biology research. Recently, using microfluidic-based devices for pharmaceutical research, in particular for the fabrication of micro- and nano-particles, has emerged as a new area of interest. The particles that can be prepared by microfluidic devices can range from micron size droplet-based emulsions to nano-sized drug loaded...
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#1Sivaraj Mehnath (University of Madras)H-Index: 3
Last. Murugaraj Jeyaraj (University of Madras)H-Index: 12
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Abstract Nanofibers based transdermal drug delivery is a promising platform, and it effectively delivers the drug to tumor sites. The objective of the study was to fabricate stimuli-responsive polymeric nanofibers encapsulated with an active targeting micellar system for in situ drug delivery. Stimuli-responsive core-shell nanofibers release the drug at target sites with minimum side effects to the other organs, decrease the drug administration concentration. Initially, we prepared CA conjugated...
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#1M. Al-Sharabi (University of Cambridge)
#2Daniel Markl (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 12
Last. Thomas Rades (UCPH: University of Copenhagen)H-Index: 61
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Abstract Fast disintegrating tablets have commonly been used for fast oral drug delivery to patients with swallowing difficulties. The different characteristics of the pore structure of such formulations influence the liquid transport through the tablet and hence affect the disintegration time and the release of the drug in the body. In this work, terahertz time-domain spectroscopy and terahertz pulsed imaging were used as promising analytical techniques to quantitatively analyse the impact of t...
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#1Asli Celebioglu (Cornell University)H-Index: 1
#2Tamer Uyar (Cornell University)H-Index: 40
Abstract Production of electrospun nanofibrous mats of cyclodextrin inclusion complexes with the incorporation of drug molecules would enable promising designing of fast dissolving delivery systems (FDDS) for oral treatments. Here, the single-step electrospinning technique has been applied to prepare cyclodextrin inclusion complex nanofibrous mats (CD-IC NM) of ferulic acid from complete aqueous systems without using any polymeric matrix. The free-standing ferulic acid/CD-IC NM have been electro...
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#1Danjun Wu (Zhejiang University of Technology)H-Index: 2
#2Lixi Zhu (Zhejiang University of Technology)H-Index: 1
Last. Gensheng Yang (Zhejiang University of Technology)H-Index: 1
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Abstract Conventional chemotherapy is effective for metastatic tumors widely present in colorectal cancer patients; however, chemotherapy may cause severe systemic toxicity due to a lack of specificity towards cancer cells. Effective delivery systems that can enhance targeted drug delivery to the desired tumor site and simultaneously protect the activity of drugs are in high demand. To that end, this study developed chitosan-based polyelectrolyte complexes (PECs) with the orientation of superpar...
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Organic chemistry
Chemistry
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