Cancer Screening: A Mathematical Model Relating Secreted Blood Biomarker Levels to Tumor Sizes

Published on Aug 19, 2008in PLOS Medicine11.048
· DOI :10.1371/journal.pmed.0050170
Amelie M. Lutz26
Estimated H-index: 26
(Stanford University),
Juergen K. Willmann13
Estimated H-index: 13
(Stanford University)
+ 2 AuthorsSanjiv S. Gambhir115
Estimated H-index: 115
(Stanford University)
Background Increasing efforts and financial resources are being invested in early cancer detection research. Blood assays detecting tumor biomarkers promise noninvasive and financially reasonable screening for early cancer with high potential of positive impact on patients' survival and quality of life. For novel tumor biomarkers, the actual tumor detection limits are usually unknown and there have been no studies exploring the tumor burden detection limits of blood tumor biomarkers using mathematical models. Therefore, the purpose of this study was to develop a mathematical model relating blood biomarker levels to tumor burden.
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