Match!

Cancer Screening: A Mathematical Model Relating Secreted Blood Biomarker Levels to Tumor Sizes

Published on Aug 19, 2008in PLOS Medicine
· DOI :10.1371/journal.pmed.0050170
Amelie M. Lutz26
Estimated H-index: 26
(Stanford University),
Juergen K. Willmann13
Estimated H-index: 13
(Stanford University)
+ 2 AuthorsSanjiv S. Gambhir113
Estimated H-index: 113
(Stanford University)
Abstract
Background Increasing efforts and financial resources are being invested in early cancer detection research. Blood assays detecting tumor biomarkers promise noninvasive and financially reasonable screening for early cancer with high potential of positive impact on patients' survival and quality of life. For novel tumor biomarkers, the actual tumor detection limits are usually unknown and there have been no studies exploring the tumor burden detection limits of blood tumor biomarkers using mathematical models. Therefore, the purpose of this study was to develop a mathematical model relating blood biomarker levels to tumor burden.
  • References (42)
  • Citations (52)
References42
Newest
#1Vitor Marcel Faça (Fred Hutchinson Cancer Research Center)H-Index: 26
#2Aviva P. Ventura (Fred Hutchinson Cancer Research Center)H-Index: 5
Last.Kathy O'Briant (Fred Hutchinson Cancer Research Center)H-Index: 13
view all 15 authors...
#1Gregorakis Ak (UoA: National and Kapodistrian University of Athens)H-Index: 4
Last.Andreas Scorilas (UoA: National and Kapodistrian University of Athens)H-Index: 50
view all 6 authors...
#1David S. Lamb (Wellington Hospital)H-Index: 27
#2David Slaney (Wellington Management Company)H-Index: 13
Last.Brett Delahunt (Wellington Management Company)H-Index: 50
view all 10 authors...
#1Taufika Islam Williams (NCSU: North Carolina State University)H-Index: 13
#2Kristina L. Toups (NCSU: North Carolina State University)H-Index: 2
Last.David C. Muddiman (NCSU: North Carolina State University)H-Index: 53
view all 6 authors...
#1Antonia Carla Testa (CUA: The Catholic University of America)H-Index: 36
#2D. Timmerman (Katholieke Universiteit Leuven)H-Index: 54
Last.Gabriella Ferrandina (CUA: The Catholic University of America)H-Index: 54
view all 9 authors...
#1John R. van Nagell (UK: University of Kentucky)H-Index: 47
#2Paul D. DePriest (UK: University of Kentucky)H-Index: 27
Last.Richard J. Kryscio (UK: University of Kentucky)H-Index: 66
view all 8 authors...
Cited By52
Newest
#1Denise Nebgen (University of Texas MD Anderson Cancer Center)H-Index: 5
#2Karen H. Lu (University of Texas MD Anderson Cancer Center)H-Index: 69
Last.Robert C. Bast (University of Texas MD Anderson Cancer Center)H-Index: 105
view all 0 authors...
#1Melanie M. Ivancic (UW: University of Wisconsin-Madison)H-Index: 4
#2Leigh W. Anson (UW: University of Wisconsin-Madison)
Last.William F. Dove (UW: University of Wisconsin-Madison)H-Index: 48
view all 9 authors...
#1Brianna Kim (Ceres)H-Index: 2
#2Robyn P. Araujo (QUT: Queensland University of Technology)H-Index: 15
Last.Alessandra Luchini (GMU: George Mason University)H-Index: 18
view all 6 authors...
#1Kelsey Boitnott Mathieu (University of Texas MD Anderson Cancer Center)H-Index: 5
#2Deepak G Bedi (University of Texas MD Anderson Cancer Center)H-Index: 13
Last.Robert C. Bast (University of Texas MD Anderson Cancer Center)H-Index: 105
view all 5 authors...
#1Tatsuya Nishihara (Keio: Keio University)H-Index: 3
#2Satoshi Kuno (UTokyo: University of Tokyo)
Last.Tomoyoshi Soga (Keio: Keio University)H-Index: 55
view all 9 authors...
#1Tatsuya Nishihara (Keio: Keio University)H-Index: 3
#2Joe Inoue (Keio: Keio University)H-Index: 1
Last.Tomoyoshi Soga (Keio: Keio University)H-Index: 55
view all 9 authors...
View next paperMathematical model identifies blood biomarker-based early cancer detection strategies and limitations.