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Cancer Screening: A Mathematical Model Relating Secreted Blood Biomarker Levels to Tumor Sizes

Published on Aug 19, 2008in PLOS Medicine11.048
· DOI :10.1371/journal.pmed.0050170
Amelie M. Lutz26
Estimated H-index: 26
(Stanford University),
Juergen K. Willmann13
Estimated H-index: 13
(Stanford University)
+ 2 AuthorsSanjiv S. Gambhir115
Estimated H-index: 115
(Stanford University)
Abstract
Background Increasing efforts and financial resources are being invested in early cancer detection research. Blood assays detecting tumor biomarkers promise noninvasive and financially reasonable screening for early cancer with high potential of positive impact on patients' survival and quality of life. For novel tumor biomarkers, the actual tumor detection limits are usually unknown and there have been no studies exploring the tumor burden detection limits of blood tumor biomarkers using mathematical models. Therefore, the purpose of this study was to develop a mathematical model relating blood biomarker levels to tumor burden.
  • References (42)
  • Citations (53)
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References42
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#1Vitor M. Faça (Fred Hutchinson Cancer Research Center)H-Index: 26
#2Aviva P. Ventura (Fred Hutchinson Cancer Research Center)H-Index: 5
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Background Elucidation of the repertoire of secreted and cell surface proteins of tumor cells is relevant to molecular diagnostics, tumor imaging and targeted therapies. We have characterized the cell surface proteome and the proteins released into the extra-cellular milieu of three ovarian cancer cell lines, CaOV3, OVCAR3 and ES2 and of ovarian tumor cells enriched from ascites fluid. Methodology and Findings To differentiate proteins released into the media from protein constituents of media u...
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#1A.K. Gregorakis (UoA: National and Kapodistrian University of Athens)H-Index: 4
#2S. StefanakisH-Index: 5
Last. Andreas Scorilas (UoA: National and Kapodistrian University of Athens)H-Index: 51
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Background Radical cystoprostatectomy and radical prostatectomy are the two major operations where prostate is totally and radically removed. Radical cystoprostatectomy is usually performed in patients with invasive bladder cancer. The aim of the study was to examine Total PSA, Free PSA, and Free/Total Ratio elimination kinetics after radical cystoprostatectomy. Methods Serum PSA, Free PSA, and Free/Total Ratio were determined preoperatively, at the time of cystoprostatectomy specimen removal an...
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#1Mark McCann (Ulster University)H-Index: 16
#2Chris I. R. Gill (Ulster University)H-Index: 23
Last. Ian Rowland (University of Reading)H-Index: 60
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Ecological data suggest a long-term diet high in plant material rich in biologically active compounds, such as the lignans, can significantly influence the development of prostate cancer over the lifetime of an individual. The capacity of a pure mammalian lignan, enterolactone (ENL), to influence the proliferation of the LNCaP human prostate cancer cell line was investigated as a function of cell density, metabolic activity, expression and secretion of prostate specific antigen (PSA), cell cycle...
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Cancer research in recent years has immensely benefited from the development of novel technologies that enable scientists to perform detailed investigations of genomes, transcriptomes, proteomes, and metabolomes. This has invariably furthered knowledge of tumorigenesis and etiology of cancer. The resulting information can, in the foreseeable future, effect a significant change in the pace of cancer research, thereby producing improvements in patient care. Ovarian cancer in particular has receive...
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