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PLOS Medicine
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#1Jason I. Chiang (University of Melbourne)H-Index: 2
#2Peter Hanlon (Glas.: University of Glasgow)H-Index: 9
Last. Sharmala Thuraisingam (University of Melbourne)H-Index: 3
view all 11 authors...
Background There is emerging interest in multimorbidity in type 2 diabetes (T2D), which can be either concordant (T2D related) or discordant (unrelated), as a way of understanding the burden of disease in T2D. Current diabetes guidelines acknowledge the complex nature of multimorbidity, the management of which should be based on the patient’s individual clinical needs and comorbidities. However, although associations between multimorbidity, glycated haemoglobin (HbA1c), and mortality in people w...
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#1Lana Fani (EUR: Erasmus University Rotterdam)H-Index: 3
#2Kimberly D. van der Willik (EUR: Erasmus University Rotterdam)H-Index: 1
Last. M. Arfan Ikram (EUR: Erasmus University Rotterdam)H-Index: 82
view all 11 authors...
Background Atherosclerotic cardiovascular disease (ASCVD) is driven by multifaceted contributions of the immune system. However, the dysregulation of immune cells that leads to ASCVD is poorly understood. We determined the association of components of innate and adaptive immunity longitudinally with ASCVD, and assessed whether arterial calcifications play a role in this association. Methods and findings Granulocyte (innate immunity) and lymphocyte (adaptive immunity) counts were determined 3 tim...
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#1Michel Kazatchkine (HEI: Graduate Institute of International and Development Studies)H-Index: 10
#2Michel Goldman (ULB: Université libre de Bruxelles)H-Index: 84
Last. J-L Vincent (ULB: Université libre de Bruxelles)H-Index: 143
view all 3 authors...
Michel Goldman and colleagues call on the European medical and scientific community to coordinate efforts on immunotherapy-based approaches to coronavirus.
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#1Tobias BrogerH-Index: 7
#2Mark P. Nicol (National Health Laboratory Service)H-Index: 41
Last. Kinuyo ChikamatsuH-Index: 8
view all 16 authors...
Background Tuberculosis (TB) is the most common cause of death in people living with HIV (PLHIV), yet TB often goes undiagnosed since many patients are not able to produce a sputum specimen, and traditional diagnostics are costly or unavailable. A novel, rapid lateral flow assay, Fujifilm SILVAMP TB LAM (SILVAMP-LAM), detects the presence of TB lipoarabinomannan (LAM) in urine, and is substantially more sensitive for diagnosing TB in PLHIV than an earlier LAM assay (Alere Determine TB LAM latera...
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#1Helen Jarvis (Newcastle University)H-Index: 15
#2Dawn Craig (Newcastle University)H-Index: 16
Last. Barbara Hanratty (Newcastle University)H-Index: 21
view all 7 authors...
Background Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease worldwide. Many individuals have risk factors associated with NAFLD, but the majority do not develop advanced liver disease: cirrhosis, hepatic decompensation, or hepatocellular carcinoma. Identifying people at high risk of experiencing these complications is important in order to prevent disease progression. This review synthesises the evidence on metabolic risk factors and their potential to predic...
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#1Atsushi Tanaka (Saga University)H-Index: 15
#2Isao Taguchi (Dokkyo Medical University)H-Index: 13
Last. Toru KatoH-Index: 7
view all 23 authors...
BACKGROUND: An elevated level of serum uric acid (SUA) is associated with an increased risk of cardiovascular disease. Pharmacological intervention with urate-lowering agents, such as the conventional purine analogue xanthine oxidase (XO) inhibitor, allopurinol, has been used widely for a long period of time in clinical practice to reduce SUA levels. Febuxostat, a novel non-purine selective inhibitor of XO, has higher potency for inhibition of XO activity and greater urate-lowering efficacy than...
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#1Mirjam Kretzschmar (UU: Utrecht University)H-Index: 46
#2Marianne A. B. van der Sande (Institute of Tropical Medicine Antwerp)H-Index: 40
Mirjam Kretzschmar and Marianne van der Sande discuss the accompanying research study by Anna McNaughton and colleagues on strategies to reduce the burden of hepatitis B in African countries.
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#1Anna L. McNaughton (University of Oxford)H-Index: 5
#2José Lourenço (University of Oxford)H-Index: 14
Last. Dominique Goedhals (University of the Free State)H-Index: 11
view all 15 authors...
Background International Sustainable Development Goals (SDGs) for elimination of hepatitis B virus (HBV) infection set ambitious targets for 2030. In African populations, infant immunisation has been fundamental to reducing incident infections in children, but overall population prevalence of chronic hepatitis B (CHB) infection remains high. In high-prevalence populations, adult catch-up vaccination has sometimes been deployed, but an alternative Test and Treat (T&T) approach could be used as an...
1 CitationsSource
#1Laura K. Murray (Johns Hopkins University)H-Index: 22
#2Jeremy C. Kane (Columbia University)
Last. Francis SimendaH-Index: 1
view all 11 authors...
Background Both intimate partner violence (IPV) and alcohol misuse are highly prevalent, and partner alcohol misuse is a significant contributor to women’s risk for IPV. There are few evidence-based interventions to address these problems in low- and middle-income countries (LMICs). We evaluated the effectiveness of an evidence-based, multi-problem, flexible, transdiagnostic intervention, the Common Elements Treatment Approach (CETA) in reducing (a) women’s experience of IPV and (b) their male p...
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#1Stephanie S. Chan (Office of the Assistant Secretary for Planning and Evaluation)
#2Andre Chappel (Office of the Assistant Secretary for Planning and Evaluation)H-Index: 1
Last. Nancy De Lew (Office of the Assistant Secretary for Planning and Evaluation)H-Index: 2
view all 9 authors...
Background In 2015, there were approximately 40,000 new HIV diagnoses in the United States. Pre-exposure prophylaxis (PrEP) is an effective strategy that reduces the risk of HIV acquisition; however, uptake among those who can benefit from it has lagged. In this study, we 1) compared the characteristics of patients who were prescribed PrEP with individuals newly diagnosed with HIV infection, 2) identified the specialties of practitioners prescribing PrEP, 3) identified metropolitan statistical a...
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