PLOS Medicine
Papers 4012
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#1Michael Fralick (U of T: University of Toronto)H-Index: 9
#2Seabastian Schneeweiss (Brigham and Women's Hospital)H-Index: 81
Last.Aaron S. Kesselheim (Brigham and Women's Hospital)H-Index: 40
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Background Desmopressin was approved by the Food and Drug Administration (FDA) in 1978 for use in diabetes insipidus and bleeding disorders, but it is also prescribed off-label for patients with nocturia. Quantifying the potential risks facing adult patients taking desmopressin has taken on added importance because a new intranasal formulation of desmopressin was approved by the FDA in 2017. Like the old formulation, the main active ingredient is desmopressin acetate, but the new formulation als...
#1Xue Li (Edin.: University of Edinburgh)H-Index: 5
#2Xiangrui Meng (Edin.: University of Edinburgh)H-Index: 4
Last.Ioanna Tzoulaki (Imperial College London)H-Index: 47
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Background The role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate its clinical relevance. Methods and findings A phenome-wide association study (PheWAS) together with a Bayesian analysis of tree-structured phenotypic model (TreeWAS) was performed to examine disease outcomes related to genetically determined serum urate levels in 339,256 unrelated Whit...
#1Jotheeswaran Amuthavalli Thiyagarajan (WHO: World Health Organization)
#2Islene Araujo de Carvalho (WHO: World Health Organization)H-Index: 8
Last.Alan D. Dangour (Lond: University of London)H-Index: 31
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Islene Araujo de Carvalho and coauthors discuss the WHO guidelines on integrated care for older people.
#1Casey Crump (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 20
#2Jan Sundquist (Lund University)H-Index: 57
Last.Kristina Sundquist (Lund University)H-Index: 47
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Background Preterm birth has previously been linked with cardiovascular disease (CVD) in adulthood. However, associations with lipid disorders (e.g., high cholesterol or triglycerides), which are major risk factors for CVD, have seldom been examined and are conflicting. Clinicians will increasingly encounter adult survivors of preterm birth and will need to understand the long-term health sequelae. We conducted the first large population-based study to determine whether preterm birth is associat...